Catalogo Ricerca UNIROMA1

The most recent experimental results have identified neuroinflammation as the main causes of the development of chronic degenerative diseases in the central nervous system (CNS), such as Alzheimer's disease and Parkinson's disease. The aim of complementary medicine is to provide support to traditional pharmacology by limiting disease progression through anti-inflammatory as well as anti-oxidant treatments. We have recently demonstrated the presence of wheat-derived bioactive compounds ca...

Regulation of Macrophage Activation and Disease Pathogenesis following Ozone Exposure by Extracellular Vesicles and miRNA Cargo

Exposure to air pollutants like ozone contributes to the pathogenesis and severity of inflammatory diseases including asthma, emphysema, and ARDS. We previously demonstrated that lung injury following of ozone is due, not only to its direct effects on the lung, but indirectly to the actions of inflammatory mediators released by activated macrophages; moreover, macrophage activation is controlled, at least in part, by epigenetic regulators particularly, noncoding microRNAs (miRNA)s. Extra...

Senatore Cappelli wheat derived biomolecules exert anti-inflammatory and anti-oxidant activity

Much attention has been focusing on wheat derived extracts for their health-promoting functions, as a source of bioactive molecules and nutraceuticals. We evaluated in a multimethodological approach the anti-inflammatory and anti- oxidant properties of hydroalcoholic extracts obtained from husks, grains, flour and pasta derived from durum wheat belonging to the ancient cultivar “Senatore Cappelli”, assessing their potential as bioactive compound sources in terms of phytochemical, antioxidant...

Treatment with polyphenols and probiotics counteracts LPS-induced morphological and functional polarization of BV-2 Microglia

Neuroinflammation is implicated in the onset of neurodegenerative diseases and occurs primarily as a result of hyperactivation of glial cells in the central nervous system (CNS). Microglia cells respond to insults through the release of inflammatory mediators such as cytokines and chemokines. Our research focuses on the study of some nutraceutical compounds that promote the morpho-functional bias of microglia toward an anti-inflammatory phenotype. We have recently demonstrated the presence of...

Attività di una soluzione fisiologica ozonizzata aggiunta a colture cellulari in vitro

L'ozono è stato impiegato con successo in diversi settori: dalla potabilizzazione delle acque, al trattamento di ferite e ulcere difficili, all'induzione di fenotipi anti-infiammatori nelle cellule dell'immunità alla capacità di adiuvare gli effetti di molti composti farmacologici nel trattamento di patologie cronico-degenerative e nella terapia del dolore. Attualmente l'ozono viene impiegato per uso topico forma di olio ozonizzato per promuovere la guarigione delle ferite e per il trattament...

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