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Recensione a: Anne Boud’hors, Frederik Krueger, Almuth Märker, and Tonio Sebastian Richter (eds.), Coptica Lipsiensia. Koptische Texte aus der Papyrus- und Ostrakasammlung der Universitätsbibliothek Leipzig (P.Lips.Copt. I), Berlin 2024

Review

Survey of transcriptome analyses of hippocampal neurogenesis with focus on adult dentate gyrus stem cells

Adult mammalian brains generate new neurons throughout life in two main niches, the dentate gyrus of the hippocampus and the subventricular zone, starting from neural stem cells (NSCs). Adult hippocampal neurogenesis is crucial for learning and memory and decreases during aging. As defined in mouse models, NSCs, which are prevalently quiescent, develop into proliferating progenitor cells, neuroblasts, and immature and mature neurons. Two visions for NSC self-renewal in the dentate gyrus have ...

E. Coli cytotoxic necrotizing factor-1 promotes colorectal carcinogenesis by causing oxidative stress, DNA damage and intestinal permeability alteration

Background: Bacterial toxins are emerging as promising hallmarks of colorectal cancer (CRC) pathogenesis. In particular, Cytotoxic Necrotizing Factor 1 (CNF1) from E. coli deserves special consideration due to the significantly higher prevalence of this toxin gene in CRC patients with respect to healthy subjects, and to the numerous tumor-promoting effects that have been ascribed to the toxin in vitro. Despite this evidence, a definitive causal link between CNF1 and CRC was missing. Here we i...

Beyond aneuploidy: embryo morphology, maternal age, and miscarriage dynamics in PGT-A selected single embryo transfer

Purpose: The study addresses whether maternal age, embryo morphology, and blastocyst developmental timing interact to influence pregnancy success rates in PGT-A selected single embryo transfer (PGT-A sSET), confirmed as euploid or exhibiting low-level (<= 40%) mosaicism; and whether the chromosomal health of the embryo mitigates all aspects of age-related fertility decline. Methods: We retrospectively analyzed 822 frozen PGT-A sSET cycles performed at Villa Mafalda private clinic (July 202...

The impact of platelet-rich plasma infusion in infertile women undergoing assisted reproduction: a systematic umbrella review of the best clinical evidence

INTRODUCTION: To date, the application of platelet-rich plasma (PRP) to women in assisted reproductive technologies is a potential therapeutic method that has been developed. This umbrella review is designed to summarize the best evidence regarding the treatment potential of PRP in infertile patients. EVIDENCE ACQUISITION: A systematic literature search was conducted on the main database (PubMed, the Cochrane Library and Web of Science) for systematic reviews and meta-analyses describing the ...

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