Catalogo Ricerca UNIROMA1

Single-cell RNA sequencing (scRNA-seq) resolves cellular heterogeneity, but expression alone captures only a slice of cell identity. Regulatory and metabolic activities—read out as transcription factor (TF) activity and metabolic flux—can be inferred from transcripts, yet they are usually analysed separately. We present a functional multi-view integration framework that unifies transcriptional, regulatory, and metabolic information into a single latent representation from one scRNA-seq datase...

Manufacturing Whiteness: How Colonial Logic Shapes AI Embodiment

The paper interrogates the racialized assumptions embedded in the design, representation, and conceptualization of human-like robots. it explores how, despite the pervasive discourse of technological neutrality, robotics and AI reproduce colonial hierarchies of race. The paper discusses the racial logic behind human-lik robot design and aims to explore how the absence of Blackness in robotic embodiment reflects deeper historical and ideological structures rooted in colonialism. It raises the ...

Survey of transcriptome analyses of hippocampal neurogenesis with focus on adult dentate gyrus stem cells

Adult mammalian brains generate new neurons throughout life in two main niches, the dentate gyrus of the hippocampus and the subventricular zone, starting from neural stem cells (NSCs). Adult hippocampal neurogenesis is crucial for learning and memory and decreases during aging. As defined in mouse models, NSCs, which are prevalently quiescent, develop into proliferating progenitor cells, neuroblasts, and immature and mature neurons. Two visions for NSC self-renewal in the dentate gyrus have ...

E. Coli cytotoxic necrotizing factor-1 promotes colorectal carcinogenesis by causing oxidative stress, DNA damage and intestinal permeability alteration

Background: Bacterial toxins are emerging as promising hallmarks of colorectal cancer (CRC) pathogenesis. In particular, Cytotoxic Necrotizing Factor 1 (CNF1) from E. coli deserves special consideration due to the significantly higher prevalence of this toxin gene in CRC patients with respect to healthy subjects, and to the numerous tumor-promoting effects that have been ascribed to the toxin in vitro. Despite this evidence, a definitive causal link between CNF1 and CRC was missing. Here we i...

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