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A Two-Phase Matheuristic for the Integrated Healthcare Timetabling Problem

The Integrated Healthcare Timetabling Problem (IHTP), introduced in the 2024 IHT Competition, addresses the coordinated optimization of Patient Admission Scheduling, Surgical Case Planning, and Nurse-to-Room assignment. The problem's complexity derives from the interdependencies among these components and the need to balance multiple objectives while respecting capacity, compatibility, and regulatory constraints.We first introduce a comprehensive Mixed-Integer Linear Programming formulation f...

Decoding RNA–RNA Interactions: The Role of Low-Complexity Repeats and a Deep Learning Framework for Sequence-Based Prediction

RNA–RNA interactions (RRIs) are fundamental to gene regulation and RNA processing, yet their molecular determinants remain unclear. In this work, we analyze several large-scale RRI datasets and identify low-complexity repeats (LCRs), including simple tandem repeats, as key drivers of RRIs. Our findings reveal that LCRs enable thermodynamically stable interactions with multiple partners, positioning them as key hubs in RNA–RNA interaction networks. These RRIs appear to be important for several...

A simulation-based optimization approach for analyzing ambulance diversion in emergency medical systems: application to an urban area of Rome

This paper deals with an important issue in Emergency Medical Systems, namely the overcrowding of the Emergency Departments (EDs). In particular, we propose a novel model based on Discrete Event Simulation (DES) for studying the Ambulance Diversion (AD), the strategy of temporarily redirect patients incoming by ambulance to another nearby ED when the receiving ED is overloaded. While AD can provide temporary relief to overcrowded EDs, it can be associated with significant risks and some healt...

Overqualified, Still Satisfied? Revisiting Job Satisfaction Among Overqualified Migrants

In the context of global population ageing, migrants are increasingly essential to sustaining labour forces across high-income countries. This study investigates the dynamics of overqualification (i.e., when workers have higher qualifications than their job requires) and job satisfaction among migrants, taking Italy – a country with one of the world’s oldest populations and a highly segmented labour market – as a case study. We pursue three main goals: (1) to examine the risk of overqualifica...

ISPRA, Rapporto sulle attività del Sistema Nazionale a rete per la Protezione dell’Ambiente nell’anno 2024 (art. 10, comma 3, l. n. 132/2016). Rapporto 2025.

Il Rapporto 2025 illustra le attività svolte nell'anno 2024 dal Sistema Nazionale a rete per la Protezione dell’Ambiente istituto dalla legge 28 giugno 2016, n. 132, rete composta dall'Istituto Superiore per la Protezione e la Ricerca Ambientale e dalle ventuno agenzie per la protezione dell'ambiente delle regioni e delle province autonome di Trento e di Bolzano. Il rapporto è un adempimento annuale previsto dall’art. 10, comma 3 della richiamata l. n. 132/2016 e delinea i principali risultat...

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