| Nome |
# |
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New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer, file e3835314-1399-15e8-e053-a505fe0a3de9
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369
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Modulating undruggable targets to overcome cancer therapy resistance, file e383532e-c364-15e8-e053-a505fe0a3de9
|
346
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|
Small molecule inhibitors of KDM5 histone demethylases increase the radiosensitivity of breast cancer cells overexpressing Jarid1b, file e3835320-fa98-15e8-e053-a505fe0a3de9
|
242
|
|
Drug design and synthesis of first in class PDZ1 targeting NHERF1 inhibitors as anticancer agents, file e3835321-b62e-15e8-e053-a505fe0a3de9
|
163
|
|
Inhibition of dengue virus replication by novel inhibitors of RNA-dependent RNA polymerase and protease activities, file e3835318-8dce-15e8-e053-a505fe0a3de9
|
155
|
|
Indolylarylsulfones, a fascinating story of highly potent human immunodeficiency virus type 1 non-nucleoside reverse transcriptase inhibitors, file e383531a-1225-15e8-e053-a505fe0a3de9
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126
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Emerging therapeutic agents for colorectal cancer, file e383532d-9843-15e8-e053-a505fe0a3de9
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123
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N-Pyrrylarylsulfones with high therapeutic potential, file e3835317-085a-15e8-e053-a505fe0a3de9
|
119
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Focus on chirality of HIV-1 non-nucleoside reverse transcriptase inhibitors, file e3835317-09b6-15e8-e053-a505fe0a3de9
|
117
|
|
Exploring the first Rimonabant analog-opioid peptide hybrid compound, as bivalent ligand for CB1 and opioid receptors, file e3835317-0b2a-15e8-e053-a505fe0a3de9
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117
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Mitotic cell death induction by targeting the mitotic spindle with tubulin-inhibitory indole derivative molecules, file e3835316-c0e6-15e8-e053-a505fe0a3de9
|
113
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|
Violacein, an indole-derived purple-colored natural pigment produced by Janthinobacterium lividum, inhibits the growth of head and neck carcinoma cell lines both in vitro and in vivo, file e3835315-5735-15e8-e053-a505fe0a3de9
|
109
|
|
β-catenin knockdown promotes nherf1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy, file e383531a-82b0-15e8-e053-a505fe0a3de9
|
100
|
|
Endogenous vs exogenous allosteric modulators in GPCRs: a dispute for shuttling CB1 among different membrane microenvironments, file e3835314-0d9e-15e8-e053-a505fe0a3de9
|
98
|
|
In vitro characterisation of a pleconaril/pirodavir-like compound with potent activity against rhinoviruses, file e3835315-5afb-15e8-e053-a505fe0a3de9
|
89
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|
Annurca apple (M. pumila Miller cv Annurca) extracts act against stress and ageing in S. cerevisiae yeast cells, file e3835316-c24a-15e8-e053-a505fe0a3de9
|
82
|
|
Design, synthesis and discovery of novel N,N'-carbazoyl-aryl-urea inhibitors of Zika NS5 methyltransferase and virus replication., file e3835325-7494-15e8-e053-a505fe0a3de9
|
80
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|
Targeting the interaction between the SH3 domain of Grb2 and Gab2, file e3835328-65a3-15e8-e053-a505fe0a3de9
|
79
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|
Modeling Epac1 interactions with the allosteric inhibitor AM-001 by co-solvent molecular dynamics, file e3835327-af36-15e8-e053-a505fe0a3de9
|
68
|
|
Discovery of Zika virus NS2B/NS3 inhibitors that prevent mice from fife-threatening infection and brain damage, file e3835329-2cf4-15e8-e053-a505fe0a3de9
|
61
|
|
Selenotriapine - an isostere of the most studied thiosemicarbazone with pronounced pro-apoptotic activity, low toxicity and ability to challenge phenotype reprogramming of 3-D mammary adenocarcinoma tumors, file e3835327-b437-15e8-e053-a505fe0a3de9
|
59
|
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Anticancer activity of (S)-5-Chloro-3-((3,5-dimethylphenyl)sulfonyl)-N-(1-oxo-1-((pyridin-4-ylmethyl)amino)propan-2-yl)-1H-indole-2-carboxamide (RS4690), a new dishevelled 1 inhibitor, file e383532e-2da4-15e8-e053-a505fe0a3de9
|
49
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Mutational analysis of the essential lipopolysaccharide-transport protein LptH of Pseudomonas aeruginosa to uncover critical oligomerization sites, file e3835328-4581-15e8-e053-a505fe0a3de9
|
45
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|
Discovery of a novel class of norovirus inhibitors with high barrier of resistance, file e383532d-9840-15e8-e053-a505fe0a3de9
|
41
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|
Targeting PDZ domains as potential treatment for viral infections, neurodegeneration and cancer, file e383532d-208c-15e8-e053-a505fe0a3de9
|
29
|
|
Discovery of novel human lactate dehydrogenase inhibitors: Structure-based virtual screening studies and biological assessment, file 8731833a-0256-4952-840b-6835a6e85c87
|
23
|
|
Novel N-(Heterocyclylphenyl)benzensulfonamide Sharing an Unreported Binding Site with T-Cell Factor 4 at the β-Catenin Armadillo Repeats Domain as an Anticancer Agent, file e481c586-3297-49db-842a-3459cd8a4226
|
19
|
|
Exploring CCRL2 chemerin binding using accelerated molecular dynamics, file e383532e-d534-15e8-e053-a505fe0a3de9
|
18
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|
Toward Highly Potent Cancer Agents by Modulating the C-2 Group of the Arylthioindole Class of Tubulin Polymerization Inhibitors, file e3835311-fdbb-15e8-e053-a505fe0a3de9
|
17
|
|
3-Aroyl-1,4-diarylpyrroles inhibit chronic myeloid leukemia cell growth through an interaction with tubulin, file e3835318-86c8-15e8-e053-a505fe0a3de9
|
17
|
|
Boom in the development of non-peptidic beta-secretase (BACE1) inhibitors for the treatment of Alzheimer's disease, file e3835311-c18f-15e8-e053-a505fe0a3de9
|
15
|
|
Indole, a Core Nucleus for Potent Inhibitors of Tubulin Polymerization., file e3835311-c283-15e8-e053-a505fe0a3de9
|
14
|
|
4-(3-Phenyl-4-(3,4,5-trimethoxybenzoyl)-1H-pyrrol-1-yl)benzenesulfonamide, a Novel Carbonic Anhydrase and Wnt/β-Catenin Signaling Pathway Dual-Targeting Inhibitor with Potent Activity against Multidrug Resistant Cancer Cells, file 627e2e0f-3a39-4d2c-8fef-60960843e574
|
12
|
|
Structure based design, synthesis and biological evaluation of novel pyrrolyl aryl sulfones (PASs) active at nanomolar concentration as HIV-1 non nucleoside reverse transcriptase inhibitors., file e3835311-b2d7-15e8-e053-a505fe0a3de9
|
11
|
|
3-Aroyl-1,4-diarylpyrroles inhibit chronic myeloid leukemia cell growth through an interaction with tubulin, file e383531d-e9b0-15e8-e053-a505fe0a3de9
|
8
|
|
Synthesis, biological evaluation, and binding mode of novel 1-[2-(diarylmethoxy)ethyl]-2-methyl-5-nitroimidazoles targeted at the HIV-1 reverse transcriptase, file e3835311-80b0-15e8-e053-a505fe0a3de9
|
7
|
|
New 1-phenyl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides inhibit hepatitis C virus replication via suppression of cyclooxygenase-2, file e3835312-5cda-15e8-e053-a505fe0a3de9
|
6
|
|
Violacein, an indole-derived purple-colored natural pigment produced by Janthinobacterium lividum, inhibits the growth of head and neck carcinoma cell lines both in vitro and in vivo, file e3835313-e8af-15e8-e053-a505fe0a3de9
|
6
|
|
New inhibitors of indoleamine 2,3-dioxygenase 1: molecular modeling studies, synthesis, and biological evaluation, file e3835315-f178-15e8-e053-a505fe0a3de9
|
6
|
|
Open vessel and cooling while heating microwave-assisted synthesis of pyridinyl N-aryl hydrazones, file e3835318-8ebd-15e8-e053-a505fe0a3de9
|
6
|
|
Discovery of new 1,1'-biphenyl-4-sulfonamides as selective subnanomolar human carbonic anhydrase II inhibitors, file e3835327-8dc5-15e8-e053-a505fe0a3de9
|
6
|
|
Discovery of 1,1'-biiphenyl-4-sulfonamides as a new class of potent and selective carbonic anhydrase XIV inhibitors, file e3835314-16e9-15e8-e053-a505fe0a3de9
|
5
|
|
Indolyl aryl Sulfones (IASs): Development of highly potent NNRTIs active against wt-HIV-1 and clinically relevant drug resistant mutants, file e3835311-8188-15e8-e053-a505fe0a3de9
|
4
|
|
Direct HPLC enantioseparation of chiral aptazepine derivatives on coated and bonded polysaccharide-based chiral stationery phases., file e3835311-c01c-15e8-e053-a505fe0a3de9
|
4
|
|
A screen for kinetochore-microtubule interaction inhibitors identifies novel antitubulin compounds, file e3835311-c081-15e8-e053-a505fe0a3de9
|
4
|
|
Pyrrolo[1,2-b][1,2,5]benzothiadiazepines (PBTDs) exert their anti-proliferative activity by interfering with Akt-mTOR signaling and bax:bcl-2 ratio modulation in cells from chronic myeloid leukemic patients, file e3835311-c18e-15e8-e053-a505fe0a3de9
|
4
|
|
Oleuropein, a component of extra virgin olive oil, lowers postprandial glycaemia in healthy subjects, file e383531a-93ba-15e8-e053-a505fe0a3de9
|
4
|
|
New 6- and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer cell growth inhibitors, file e383531a-dcc3-15e8-e053-a505fe0a3de9
|
4
|
|
A high-throughput screening of a chemical compound library in ovarian cancer stem cells, file e383531e-0fb0-15e8-e053-a505fe0a3de9
|
4
|
|
Induction of Ferroptosis in Glioblastoma and Ovarian Cancers by a New Pyrrole Tubulin Assembly Inhibitor, file 14ddf683-85fe-4882-b5d4-bbfe6c5e2deb
|
3
|
|
Single-run chemo- and enantio-selective high-performance liquid chromatography separation of tramadol and its principal metabolite, O-desmethyltramadol, using a chlorinated immobilized amylose-based chiral stationary phase under multimodal elution conditions, file 99cee97e-ccb6-42f2-8bca-616966d54cc3
|
3
|
|
Toll-like receptor 4-dependent platelet-related thrombosis in SARS-CoV-2 infection, file d677836c-b1be-49fc-b71e-6e6343267c90
|
3
|
|
Pharmacological folding chaperones act as allosteric ligands of Frizzled4, file e3835312-6c9b-15e8-e053-a505fe0a3de9
|
3
|
|
A simplified synthesis of ethyl 5-chloro-6-fluro-1H-indole-2-carboxylate and ethyl 5-chloro-4-fluro-1H-indole-2-carboxylate, file e3835312-bd4d-15e8-e053-a505fe0a3de9
|
3
|
|
Bicyclic γ-amino acids as inhibitors of γ-aminobutyrate aminotransferase, file e3835315-45ba-15e8-e053-a505fe0a3de9
|
3
|
|
Arginine- and lysine-rich peptides: synthesis, characterization and antimicrobial activity, file e383531b-584c-15e8-e053-a505fe0a3de9
|
3
|
|
Switching on the activity of 1,5-diaryl-pyrrole derivatives against drug-resistant ESKAPE bacteria: structure-activity relationships and mode of action studies, file e3835322-06e7-15e8-e053-a505fe0a3de9
|
3
|
|
Identification of a pharmacological inhibitor of Epac1 that protects the heart against acute and chronic models of cardiac stress, file e3835323-f22a-15e8-e053-a505fe0a3de9
|
3
|
|
Sulfonamide inhibitors of beta-catenin signaling as anticancer agents with different output on c-Myc, file e3835329-2cfb-15e8-e053-a505fe0a3de9
|
3
|
|
New frontiers in selective human MAO-B inhibitors, file e3835329-d21e-15e8-e053-a505fe0a3de9
|
3
|
|
Discovery of pyrrole derivatives for the treatment of glioblastoma and chronic myeloid leukemia, file e383532c-7033-15e8-e053-a505fe0a3de9
|
3
|
|
Targeting the Grb2 cSH3 domain: design, synthesis and biological evaluation of the first series of modulators, file a1266567-afef-4c80-bd57-7b2f43f0a90f
|
2
|
|
Recent advances in drug discovery for Triple-Negative Breast cancer treatment, file ae91e190-75fb-4c97-a531-62d74d35e3c5
|
2
|
|
Structure-based lead optimization and biological evaluation of BAX direct activators as novel potential anticancer agents, file e3835312-6c9a-15e8-e053-a505fe0a3de9
|
2
|
|
New indole tubulin assembly inhibitors with stable arrest of mitotic progression, enhanced stimulation of natural killer cell cytotoxic activity and repression of Hedgehog-dependent cancer, file e3835316-c9b9-15e8-e053-a505fe0a3de9
|
2
|
|
Chiral indolylarylsulfone non-nucleoside reverse transcriptase inhibitors as new potent and broad spectrum anti-HIV-1 agents, file e3835318-c9cd-15e8-e053-a505fe0a3de9
|
2
|
|
A negative allosteric modulator of WNT receptor frizzled 4 switches into an allosteric agonist, file e3835319-dd6a-15e8-e053-a505fe0a3de9
|
2
|
|
Structure-based drug design of potent pyrazole derivatives against Rhinovirus replication, file e383531d-365f-15e8-e053-a505fe0a3de9
|
2
|
|
Small molecule inhibitors of kdm5 histone demethylases increase the radiosensitivity of breast cancer cells overexpressing JARID1B, file e3835324-0248-15e8-e053-a505fe0a3de9
|
2
|
|
Design, synthesis and biological evaluation of PDZ1 targeting NHERF1 inhibitors as anticancer agents, file e3835324-0461-15e8-e053-a505fe0a3de9
|
2
|
|
HDAC inhibition induces expression of scaffolding proteins critical for tumor progression in pediatric glioma: focus on EBP50 and IRSp53, file e3835329-6970-15e8-e053-a505fe0a3de9
|
2
|
|
A Novel Validated UHPLC Method for the Estimation of Rosuvastatin and Its Complete Impurity Profile in Tablet Formulations, file 1455ec8a-60dd-4f81-8b9a-6b7b9a74398e
|
1
|
|
RS6077 induces mitotic arrest and selectively activates cell death in human cancer cell lines and in a lymphoma tumor in vivo, file 85ba51af-eefc-425c-a1d0-8a2af154e452
|
1
|
|
Synthetic approaches to difluoroindolecarboxylic acid ethyl esters., file e3835311-8080-15e8-e053-a505fe0a3de9
|
1
|
|
The tubulin colchicine domain: a molecular modelling perspective., file e3835311-d499-15e8-e053-a505fe0a3de9
|
1
|
|
Exploring (4-substituted-thiazol-2-yl)hydrazine derivatives of 2-, 3-, and 4-acetylpyridine as selective and reversible hMAO-B inhibitors., file e3835312-4cc3-15e8-e053-a505fe0a3de9
|
1
|
|
De novo computer-aided design of novel antiviral agents., file e3835312-4cc6-15e8-e053-a505fe0a3de9
|
1
|
|
Pro-apoptotic and pro-differentiation induction by 8-quinolinecarboxaldehyde selenosemicarbazone and its Co(III) complex in human cancer cell lines, file e3835315-519a-15e8-e053-a505fe0a3de9
|
1
|
|
VP1 crystal structure-guided exploration and optimization of 4,5-dimethoxybenzene-based inhibitors of rhinovirus 14 infection, file e3835315-a1af-15e8-e053-a505fe0a3de9
|
1
|
|
Kinetic characterization of 4,4'-biphenylsulfonamides as selective non-zinc binding MMP inhibitors, file e3835316-b3e0-15e8-e053-a505fe0a3de9
|
1
|
|
Antiproliferative and proapoptotic effects of a pyrrole containing arylthioindole in human Jurkat leukemia cell line and multidrug-resistant Jurkat/A4 cells, file e3835316-fefb-15e8-e053-a505fe0a3de9
|
1
|
|
Distinct temporal fingerprint for cyclic adenosine monophosphate (cAMP) signaling of Indole-2-carboxamides as allosteric modulators of the cannabinoid receptors, file e3835316-fefd-15e8-e053-a505fe0a3de9
|
1
|
|
3-Aroyl-1-arylpyrroles as new anticancer agents, file e3835317-0a11-15e8-e053-a505fe0a3de9
|
1
|
|
Computer-aided identification and lead optimization of dual murine double minute 2 and 4 binders: structure-activity relationship studies and pharmacological activity, file e3835318-89d7-15e8-e053-a505fe0a3de9
|
1
|
|
Heterocyclic pharmacochemistry of new rhinovirus antiviral agents: a combined computational and experimental study, file e3835318-bc7e-15e8-e053-a505fe0a3de9
|
1
|
|
Structure-based virtual screening to get new scaffold inhibitors of the Ser/Thr protein kinase PknB from Mycobacterium tuberculosis, file e3835318-ccc7-15e8-e053-a505fe0a3de9
|
1
|
|
Bax activation blocks self-renewal and induces apoptosis of human glioblastoma stem cells, file e3835319-f734-15e8-e053-a505fe0a3de9
|
1
|
|
Towards modern anticancer agents that interact with tubulin, file e3835321-5b61-15e8-e053-a505fe0a3de9
|
1
|
|
First in class pdz1 targeting NHERF1 inhibitors as anticancer agents, file e3835321-6e15-15e8-e053-a505fe0a3de9
|
1
|
|
Treating chronic myeloid leukemia by inhibition of tubulin polymerization, file e3835321-b769-15e8-e053-a505fe0a3de9
|
1
|
|
Nox2-mediated platelet activation by glycoprotein (GP) VI: Effect of rivaroxaban alone and in combination with aspirin, file e3835321-f7c7-15e8-e053-a505fe0a3de9
|
1
|
|
Structure-activity relationship studies and in vitro and in vivo anticancer activity of novel 3-aroyl-1,4-diarylpyrroles against solid tumors and hematological malignancies, file e3835323-f9c0-15e8-e053-a505fe0a3de9
|
1
|
|
New indolylarylsulfone non-nucleoside reverse transcriptase inhibitors show low nanomolar inhibition of single and double HIV-1 mutant strains, file e3835327-9f87-15e8-e053-a505fe0a3de9
|
1
|
|
CXCR4 antagonism sensitizes cancer cells to novel indole-based MDM2/4 inhibitors in glioblastoma multiforme, file e383532c-68c3-15e8-e053-a505fe0a3de9
|
1
|
|
RS4651 suppresses lung fibroblast activation via the TGF-β1/SMAD signalling pathway, file e383532c-7d34-15e8-e053-a505fe0a3de9
|
1
|
|
Enantiomerization barrier of 1-[2-(2-methyl-2-methoxycarbonylacetamido) benzenesulfonyl]-1h-pyrrole studied by enantioselective dynamic HPLC, classical off column technique and computational approach, file e383532d-a7c0-15e8-e053-a505fe0a3de9
|
1
|
|
Emerging Direct Targeting β-Catenin Agents, file eaa6ffb9-084c-46a3-a880-4db4a4e1e47e
|
1
|
|
EFFICACY AND SAFETY OF A NOVEL FOOD SUPPLEMENT IN THE TREATMENT OF FUNCTIONAL DYSPEPSIA: A PILOT OPEN STUDY, file f3d32211-36ce-4d58-954a-a1a6a664da48
|
1
|
| Totale |
3.286 |