Protein assemblies named kinetochores bind sister chromatids to the mitotic spindle and orchestrate sister chromatid segregation. Interference with kinetochore activity triggers a spindle checkpoint mediated arrest in mitosis, which frequently ends in cell death. We set out to identify small compounds that inhibit kinetochore-microtubule binding for use in kinetochore-spindle interaction studies and to develop them into novel anticancer drugs.

A screen for kinetochore-microtubule interaction inhibitors identifies novel antitubulin compounds / Screpanti, E; Santaguida, S; Mguyen, T; Silvestri, Romano; Gussio, R; Musacchio, A; Hamel, E; DE WULF, P.. - In: PLOS ONE. - ISSN 1932-6203. - ELETTRONICO. - 5:(2010), pp. 1-13. [10.1371/journal.pone.0011603]

A screen for kinetochore-microtubule interaction inhibitors identifies novel antitubulin compounds

SILVESTRI, Romano;
2010

Abstract

Protein assemblies named kinetochores bind sister chromatids to the mitotic spindle and orchestrate sister chromatid segregation. Interference with kinetochore activity triggers a spindle checkpoint mediated arrest in mitosis, which frequently ends in cell death. We set out to identify small compounds that inhibit kinetochore-microtubule binding for use in kinetochore-spindle interaction studies and to develop them into novel anticancer drugs.
2010
01 Pubblicazione su rivista::01a Articolo in rivista
A screen for kinetochore-microtubule interaction inhibitors identifies novel antitubulin compounds / Screpanti, E; Santaguida, S; Mguyen, T; Silvestri, Romano; Gussio, R; Musacchio, A; Hamel, E; DE WULF, P.. - In: PLOS ONE. - ISSN 1932-6203. - ELETTRONICO. - 5:(2010), pp. 1-13. [10.1371/journal.pone.0011603]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/71306
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