Synthetic approaches to ethyl 4,5-difluoroindole-2-carboxylate and ethyl 5,6-difluoroindole-2-carboxylate by Fischer indole synthesis and by the reaction of lithiated N-BOC-3,4-difluoro-2-methylaniline with diethyl oxalate or ethyl bromopyruvate were investigated. A simple and direct preparation of ethyl 4,5-difluoroindole-3-carboxylate from lithiated N-BOC-3,4-difluoroaniline and ethyl bromopyruvate was found.
Synthetic approaches to difluoroindolecarboxylic acid ethyl esters / Silvestri, Romano; Artico, Marino; LA REGINA, Giuseppe; DE MARTINO, G.. - In: ARKIVOC. - ISSN 1551-7012. - 5:(2004), pp. 26-31. [10.3998/ark.5550190.0005.503]
Synthetic approaches to difluoroindolecarboxylic acid ethyl esters.
SILVESTRI, Romano;ARTICO, Marino;LA REGINA, GIUSEPPE;
2004
Abstract
Synthetic approaches to ethyl 4,5-difluoroindole-2-carboxylate and ethyl 5,6-difluoroindole-2-carboxylate by Fischer indole synthesis and by the reaction of lithiated N-BOC-3,4-difluoro-2-methylaniline with diethyl oxalate or ethyl bromopyruvate were investigated. A simple and direct preparation of ethyl 4,5-difluoroindole-3-carboxylate from lithiated N-BOC-3,4-difluoroaniline and ethyl bromopyruvate was found.File allegati a questo prodotto
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