We reported the first example of open vessel and cooling while heating microwave-assisted synthesis of pyridinyl N-aryl hydrazones. Compounds were prepared in excellent isolated yields (88−98%) in only 5 min, by reacting 4- and 2,4-(di)substituted phenylhydrazines, bearing both electron-donating (4-CH3, 4-OCH3) and -withdrawing (4-Cl, 4-Br, 4-CF3, 4-NO2, 2,4-Cl2) groups with 2-, 3-, and 4-acetylpyridine. The method was successfully extended to other carbonyl compounds.
Open vessel and cooling while heating microwave-assisted synthesis of pyridinyl N-aryl hydrazones / La Regina, G.; Gatti, V.; Piscitelli, F.; Silvestri, R.. - In: ACS COMBINATORIAL SCIENCE. - ISSN 2156-8952. - STAMPA. - 13:(2011), pp. 2-6. [10.1021/co100015b]
Open vessel and cooling while heating microwave-assisted synthesis of pyridinyl N-aryl hydrazones
La Regina, G.
;Gatti, V.;Piscitelli, F.;Silvestri, R.
2011
Abstract
We reported the first example of open vessel and cooling while heating microwave-assisted synthesis of pyridinyl N-aryl hydrazones. Compounds were prepared in excellent isolated yields (88−98%) in only 5 min, by reacting 4- and 2,4-(di)substituted phenylhydrazines, bearing both electron-donating (4-CH3, 4-OCH3) and -withdrawing (4-Cl, 4-Br, 4-CF3, 4-NO2, 2,4-Cl2) groups with 2-, 3-, and 4-acetylpyridine. The method was successfully extended to other carbonyl compounds.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
