This review illustrates the various studies made to investigate the activity of N-pyrrylarylsulfone containing compounds as potential antiviral, anticancer and SNC drugs. A number of synthetic approaches to obtain tetracyclic, tricyclic and non-cyclic compounds, and their biological activity with regard to structure–activity relationships (SARs) have been reviewed. The literature reviewed here may provide useful information on the potential of N-pyrrylarylsulfone pharmacophore as well as suggest concepts for the design and synthesis of new N-pyrrylarylsulfone based agents.
N-Pyrrylarylsulfones with high therapeutic potential / Famiglini, Valeria; Silvestri, Romano; Castellano, Sabrina. - In: MOLECULES. - ISSN 1420-3049. - ELETTRONICO. - 22:3(2017). [10.3390/molecules22030434]
N-Pyrrylarylsulfones with high therapeutic potential
FAMIGLINI, VALERIA;SILVESTRI, Romano;
2017
Abstract
This review illustrates the various studies made to investigate the activity of N-pyrrylarylsulfone containing compounds as potential antiviral, anticancer and SNC drugs. A number of synthetic approaches to obtain tetracyclic, tricyclic and non-cyclic compounds, and their biological activity with regard to structure–activity relationships (SARs) have been reviewed. The literature reviewed here may provide useful information on the potential of N-pyrrylarylsulfone pharmacophore as well as suggest concepts for the design and synthesis of new N-pyrrylarylsulfone based agents.| File | Dimensione | Formato | |
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