Aberrant accumulation of β-catenin in the cell nucleus as a result of deregulation of the Wnt/β-catenin pathway is found in various types of cancer. Direct β-catenin targeting agents are being researched despite obstacles; however, specific β-catenin drugs for clinical treatments have not been approved so far. We focused on direct β-catenin targeting of potential therapeutic value as anticancer agents. This review provides recent advances on small molecule β-catenin agents. Structure-activity relationships and biological activities of reported inhibitors are discussed. This work provides useful knowledge in the discovery of β-catenin agents.

Emerging Direct Targeting β-Catenin Agents / Nalli, M.; Masci, D.; Urbani, A.; La Regina, G.; Silvestri, R.. - In: MOLECULES. - ISSN 1420-3049. - 27:22(2022), p. 7735. [10.3390/molecules27227735]

Emerging Direct Targeting β-Catenin Agents

Nalli M.;Masci D.;La Regina G.;Silvestri R.
2022

Abstract

Aberrant accumulation of β-catenin in the cell nucleus as a result of deregulation of the Wnt/β-catenin pathway is found in various types of cancer. Direct β-catenin targeting agents are being researched despite obstacles; however, specific β-catenin drugs for clinical treatments have not been approved so far. We focused on direct β-catenin targeting of potential therapeutic value as anticancer agents. This review provides recent advances on small molecule β-catenin agents. Structure-activity relationships and biological activities of reported inhibitors are discussed. This work provides useful knowledge in the discovery of β-catenin agents.
2022
anticancer agent; inhibitor; small molecule; β-catenin
01 Pubblicazione su rivista::01a Articolo in rivista
Emerging Direct Targeting β-Catenin Agents / Nalli, M.; Masci, D.; Urbani, A.; La Regina, G.; Silvestri, R.. - In: MOLECULES. - ISSN 1420-3049. - 27:22(2022), p. 7735. [10.3390/molecules27227735]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1669809
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