Catalogo dei prodotti della ricerca

GIANNI, STEFANO
 Distribuzione geografica
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Continente #
NA - Nord America 6.837
EU - Europa 2.482
AS - Asia 1.551
SA - Sud America 206
AF - Africa 77
OC - Oceania 51
Totale 11.204
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Nazione #
US - Stati Uniti d'America 6.695
IT - Italia 1.201
SG - Singapore 586
CN - Cina 368
IN - India 300
SE - Svezia 242
DE - Germania 181
FI - Finlandia 163
RU - Federazione Russa 157
GB - Regno Unito 150
CA - Canada 131
BR - Brasile 123
UA - Ucraina 96
AR - Argentina 69
AU - Australia 49
ID - Indonesia 47
KR - Corea 43
TG - Togo 42
HK - Hong Kong 40
BG - Bulgaria 38
NL - Olanda 37
FR - Francia 31
IE - Irlanda 30
JP - Giappone 30
BE - Belgio 26
TR - Turchia 24
IR - Iran 22
AT - Austria 21
DK - Danimarca 17
TW - Taiwan 17
LT - Lituania 15
CH - Svizzera 13
ES - Italia 13
RO - Romania 13
BD - Bangladesh 11
IL - Israele 11
PL - Polonia 11
PK - Pakistan 9
TH - Thailandia 8
DZ - Algeria 7
IQ - Iraq 7
PT - Portogallo 7
ZA - Sudafrica 7
EC - Ecuador 6
AZ - Azerbaigian 5
EG - Egitto 5
MX - Messico 4
MY - Malesia 4
PA - Panama 4
PE - Perù 4
TN - Tunisia 4
ZW - Zimbabwe 4
GR - Grecia 3
LU - Lussemburgo 3
NO - Norvegia 3
VN - Vietnam 3
AE - Emirati Arabi Uniti 2
KE - Kenya 2
KG - Kirghizistan 2
KZ - Kazakistan 2
MA - Marocco 2
NZ - Nuova Zelanda 2
SC - Seychelles 2
UZ - Uzbekistan 2
VE - Venezuela 2
AL - Albania 1
BH - Bahrain 1
BY - Bielorussia 1
CO - Colombia 1
CR - Costa Rica 1
CZ - Repubblica Ceca 1
DO - Repubblica Dominicana 1
EE - Estonia 1
ET - Etiopia 1
GE - Georgia 1
HR - Croazia 1
HU - Ungheria 1
JM - Giamaica 1
LA - Repubblica Popolare Democratica del Laos 1
LV - Lettonia 1
MD - Moldavia 1
ME - Montenegro 1
MK - Macedonia 1
MO - Macao, regione amministrativa speciale della Cina 1
PH - Filippine 1
PY - Paraguay 1
QA - Qatar 1
RS - Serbia 1
SA - Arabia Saudita 1
SN - Senegal 1
SY - Repubblica araba siriana 1
Totale 11.204
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Città #
Fairfield 1.131
Rome 614
Ashburn 529
Woodbridge 476
Seattle 455
Houston 432
Cambridge 393
Wilmington 376
Chandler 375
Singapore 344
Ann Arbor 218
San Paolo di Civitate 172
Beijing 168
Princeton 165
Fremont 136
Lawrence 125
Santa Clara 123
Plano 118
Boston 86
Millbury 78
Ottawa 73
San Diego 69
New York 68
Helsinki 58
Federal 55
Jakarta 47
Andover 46
Lomé 42
Boardman 37
Sofia 37
Dearborn 36
Nuremberg 34
Toronto 32
Jacksonville 30
Moscow 30
Stockholm 30
Dublin 29
Falkenstein 26
Falls Church 26
Southend 26
Milan 25
Des Moines 24
Frankfurt am Main 22
Hefei 22
London 22
Norwalk 21
Nanjing 18
Brussels 17
Los Angeles 17
Yubileyny 17
Vienna 16
Hong Kong 15
Madison 14
Baltimore 13
San Mateo 13
Shanghai 13
Bremen 12
Brisbane 12
Council Bluffs 12
Guangzhou 12
Mannheim 11
Avezzano 10
Washington 10
Amsterdam 9
Copenhagen 9
Montreal 9
Phoenix 9
Sydney 9
Warsaw 9
Ankara 8
Canberra 8
Istanbul 8
Kunming 8
Lappeenranta 8
Munich 8
Oxford 8
Tokyo 8
Buenos Aires 7
Decatur 7
Melbourne 7
Perth 7
Philadelphia 7
Piscataway 7
Redwood City 7
San Francisco 7
San Jose 7
Tehran 7
Tempe 7
Verona 7
Bühl 6
Dhaka 6
Fasano 6
Pittsburgh 6
Seongdong-gu 6
Shenyang 6
Worcester 6
Athens 5
Baku 5
Belo Horizonte 5
Berlin 5
Totale 7.977
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Nome #
Critical assessment of genome interpretation consortium. CAGI, the critical assessment of genome interpretation, establishes progress and pprospects for computational genetic variant interpretation methods. 980
Drug design and synthesis of first in class PDZ1 targeting NHERF1 inhibitors as anticancer agents 176
Anticancer activity of (S)-5-Chloro-3-((3,5-dimethylphenyl)sulfonyl)-N-(1-oxo-1-((pyridin-4-ylmethyl)amino)propan-2-yl)-1H-indole-2-carboxamide (RS4690), a new dishevelled 1 inhibitor 132
Targeting the interaction between the SH3 domain of Grb2 and Gab2 127
β-catenin knockdown promotes nherf1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy 127
Characterization of human frataxin missense variants in cancer tissues 120
Investigating the molecular basis of the aggregation propensity of the pathological d76n mutant of beta-2 microglobulin: role of the denatured state 113
Sequence-specific long range networks in PSD-95/discs large/ZO-1 (PDZ) domains tune their binding selectivity. 111
The kinetics of folding of the NSH2 domain from p85 111
Ligand binding to the pdz domains of postsynaptic density protein 95 96
The folding pathway of the KIX domain 96
Hidden kinetic traps in multidomain folding highlight the presence of a misfolded but functionally competent intermediate 96
Azole drugs trap cytochrome P450 EryK in alternative conformational states 92
The folding mechanism of c-type cytochromes 91
Addressing the role of the α-helical extension in the folding of the third PDZ domain from PSD-95 90
A sequential binding mechanism in a PDZ domain. 87
Molecular recognition by templated folding of an intrinsically disordered protein 87
Demonstration of a folding after binding mechanism in the recognition between the measles virus NTAIL and X domains 86
Towards a structural biology of the hydrophobic effect in protein folding 86
A conserved folding mechanism for PDZ domains 85
An obligatory intermediate in the folding pathway of cyctochrome c552 from Hydrogenobacter thermophilus 84
Comparing the binding properties of peptides mimicking the envelope protein of sars-cov and sars-cov-2 to the pdz domain of the tight junction-associated pals1 protein 84
Supertertiary protein structure affects an allosteric network 84
“Comparison of successive transition states for folding reveals alternative early folding pathways of two homologous proteins 83
Refolding kinetics of cyt c551 from Pseudomonas aeruginosa reveals a mechanistic difference between guanidine and urea. 82
Snapshots of protein folding. A study on the multiple transition state pathway of cytochrome c(551) from Pseudomonas aeruginosa. 82
An on-pathway intermediate in the folding of a PDZ domain 80
Plasticity of the protein folding landscape: Switching between on- and off-pathway intermediates 80
A folding-after-binding mechanism describes the recognition between the transactivation domain of c-Myb and the KIX domain of the CREB-binding protein. 80
The folding mechanism of the SH3 domain from Grb2 79
Coupled binding and folding of intrinsically disordered proteins: what can we learn from kinetics? 78
Activation barrier-limited folding and conformational sampling of a dynamic protein domain 78
A conserved hydrogen-bond network stabilizes the structure of Beta class glutathione S-transferases. 77
A PDZ domain recapitulates a unifying mechanism for protein folding 77
Regulation of the human phosphatase ptpn4 by the inter-domain linker connecting the pdz and the phosphatase domains 77
Agitation and High Ionic Strength Induce Amyloidogenesis of a Folded PDZ Domain in Native Conditions 76
Cytochrome c551 as a model system for protein folding 76
The kinetics of PDZ domain-ligand interactions and implications for the binding mechanism 76
How Robust Is the Mechanism of Folding-Upon-Binding for an Intrinsically Disordered Protein? 76
The effect of proline cis‐trans isomerization on the folding of the C‐terminal SH2 domain from p85 76
Kinetic folding mechanism of PDZ2 from PTP-BL 75
Structural and functional characterization of CcmG from Pseudomonas aeruginosa, a key component of the bacterial cytochrome c maturation apparatus 75
Frustration sculpts the early stages of protein folding 75
The Denatured State Dictates the Topology of Two Proteins with Almost Identical Sequence but Different Native Structure and Function 75
Targeting PDZ domains as potential treatment for viral infections, neurodegeneration and cancer 75
Identification and structural characterization of an intermediate in the folding of the measles virus x domain 74
Double mutant cycles as a tool to address folding, binding, and allostery 74
Probing the role of backbone hydrogen bonds in protein-peptide interactions by amide-to-ester mutations. 74
Understanding the effect of alternative splicing in the folding and function of the second pdz from protein tyrosine phosphatase-bl 73
Mechanism of folding and binding of the n-terminal SH2 domain from SHP2 73
Investigating the structural plasticity of a cytochrome P450: three-dimensional structures of P450 EryK and binding to its physiological substrate. 73
Binding induced folding: Lessons from the kinetics of interaction between NTAIL and XD 73
On the effects of disordered tails, supertertiary structure and quinary interactions on the folding and function of protein domains 73
The kinetics of folding of frataxin. 72
Biophysical characterization of the binding mechanism between the MATH domain of SPOP and its physiological partners 71
Demonstration of long-range interactions in a PDZ domain by NMR, kinetics, and protein engineering 71
Mapping the allosteric network within a SH3 domain 71
A strategic protein in cytochrome c maturation: Three-dimensional structure of CcmH and binding to apocytochrome c 71
Stability of an aggregation-prone partially folded state of human profilin-1 correlates with aggregation propensity 70
PDZ domains: folding and binding. 68
InSiDDe: A server for designing artificial disordered proteins 68
Folding mechanism of the C-terminal domain of nucleophosmin: residual structure in the denatured state and its pathophysiological significance 67
Analyzing the folding and binding steps of an intrinsically disordered protein by protein engineering 67
Folding and misfolding of a PDZ tandem repeat 67
Probing the effects of local frustration in the folding of a multidomain protein 67
Folding and stability of globular proteins and implications for function 67
The kinetic pathway of folding of barnase. 66
Protein Folding and Misfolding 66
Mutational analysis of the binding-induced folding reaction of the mixed-lineage leukemia protein to the KIX domain. 66
Demonstration of a low-energy on-pathway intermediate in a fast-folding protein by kinetics, protein engineering, and simulation. 66
The mechanism of binding of the KIX domain to the mixed lineage leukemia protein and its allosteric role in the recognition of c-Myb. 66
Mechanism of Na(+) binding to thrombin resolved by ultra-rapid kinetics. 65
A complex equilibrium among partially unfolded conformations in monomeric transthyretin. 65
Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases 65
Understanding the frustration arising from the competition between function, misfolding, and aggregation in a globular protein. 64
Partner-mediated polymorphism of an intrinsically disordered protein 64
Modulation of measles virus NTAIL interactions through fuzziness and sequence features of disordered binding sites 64
Side-chain interactions form late and cooperatively in the binding reaction between disordered peptides and PDZ domains 64
Determining folding and binding properties of the C-terminal SH2 domain of SHP2 64
Folding and binding mechanisms of the SH2 domain from Crkl 64
Unveiling the molecular basis of the noonan syndrome-causing mutation T42A of SHP2 63
Editorial overview: Folding and binding: In silico, in vitro and in cellula 62
Interactions outside the Boundaries of the Canonical Binding Groove of a PDZ Domain Influence Ligand Binding 61
Structure of the transition state for the binding of c-Myb and KIX highlights an unexpected order for a disordered system. 61
Parallel pathways in cytochrome c551 folding 61
An expanded view of the protein folding landscape of PDZ domains. 61
The structure of the major transition state for folding of an FF domain from experiment and simulation. 61
Understanding the binding induced folding of intrinsically disordered proteins by protein engineering: caveats and pitfalls 61
Understanding the molecular basis of folding cooperativity through a comparative analysis of a multidomain protein and its isolated domains 60
Molecular medicine - to be or not to be 60
Mechanisms of protein folding. 60
The mechanism of binding of the second PDZ domain from the Protein Tyrosine Phosphatase-BL to the Adenomatous Polyposis Coli tumor suppressor 59
Protein folding: vexing debates on a fundamental problem 59
How fast is protein– ligand association? 59
A structurally heterogeneous transition state underlies coupled binding and folding of disordered proteins 59
Targeting the Grb2 cSH3 domain: design, synthesis and biological evaluation of the first series of modulators 58
Structural characterization of an on-pathway intermediate and transition state in the folding of the N-terminal SH2 domain from SHP2 58
Unveiling induced folding of intrinsically disordered proteins - Protein engineering, frustration and emerging themes 58
The binding mechanisms of intrinsically disordered proteins. 57
Structural characterization of a misfolded intermediate populated during the folding process of a PDZ domain 57
Totale 8.537
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Categoria #
all - tutte 37.082
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 37.082
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020678 0 0 0 0 0 0 0 0 280 212 114 72
2020/2021967 101 125 76 74 19 164 23 65 103 117 58 42
2021/20221.659 68 97 180 41 191 84 43 187 151 139 171 307
2022/20231.714 289 420 69 122 186 151 33 127 175 25 74 43
2023/20241.473 77 122 66 61 99 115 23 112 103 268 245 182
2024/20251.947 161 185 159 247 294 281 283 257 80 0 0 0
Totale 11.611