| Nome |
# |
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Editorial overview: Folding and binding: In silico, in vitro and in cellula, file e383531a-e12a-15e8-e053-a505fe0a3de9
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172
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Drug design and synthesis of first in class PDZ1 targeting NHERF1 inhibitors as anticancer agents, file e3835321-b62e-15e8-e053-a505fe0a3de9
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163
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Emerging therapeutic agents for colorectal cancer, file e383532d-9843-15e8-e053-a505fe0a3de9
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123
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Critical assessment of genome interpretation consortium. CAGI, the critical assessment of genome interpretation, establishes progress and pprospects for computational genetic variant interpretation methods., file b88a409a-6ddf-461b-97bd-a9f1137857a1
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114
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β-catenin knockdown promotes nherf1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy, file e383531a-82b0-15e8-e053-a505fe0a3de9
|
100
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Seeking allosteric networks in PDZ domains, file e3835323-ca22-15e8-e053-a505fe0a3de9
|
100
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The kinetics of folding of the NSH2 domain from p85, file e3835320-df46-15e8-e053-a505fe0a3de9
|
95
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Double mutant cycles as a tool to address folding, binding, and allostery, file e3835328-ef3c-15e8-e053-a505fe0a3de9
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95
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The effect of proline cis‐trans isomerization on the folding of the C‐terminal SH2 domain from p85, file e3835324-d2ca-15e8-e053-a505fe0a3de9
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93
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InSiDDe: A server for designing artificial disordered proteins, file e383531a-8c93-15e8-e053-a505fe0a3de9
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87
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Investigating the molecular basis of the aggregation propensity of the pathological d76n mutant of beta-2 microglobulin: role of the denatured state, file e383531f-436d-15e8-e053-a505fe0a3de9
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86
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Unveiling the molecular basis of the noonan syndrome-causing mutation T42A of SHP2, file e3835324-d2c9-15e8-e053-a505fe0a3de9
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83
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Targeting the interaction between the SH3 domain of Grb2 and Gab2, file e3835328-65a3-15e8-e053-a505fe0a3de9
|
79
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Towards a structural biology of the hydrophobic effect in protein folding, file e3835317-082c-15e8-e053-a505fe0a3de9
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78
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Addressing the role of the α-helical extension in the folding of the third PDZ domain from PSD-95, file e3835318-334a-15e8-e053-a505fe0a3de9
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78
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Mapping the allosteric network within a SH3 domain, file e3835323-b445-15e8-e053-a505fe0a3de9
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74
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Regulation of the human phosphatase ptpn4 by the inter-domain linker connecting the pdz and the phosphatase domains, file e3835318-1e88-15e8-e053-a505fe0a3de9
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72
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SH2 Domains: folding, binding and therapeutical approaches, file e795ec9f-b754-45f0-b33e-409c7cbd624e
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71
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Understanding the binding induced folding of intrinsically disordered proteins by protein engineering: caveats and pitfalls, file e3835326-40b0-15e8-e053-a505fe0a3de9
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66
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Understanding the mechanism of binding between Gab2 and the C terminal SH3 domain from Grb2, file e3835318-0275-15e8-e053-a505fe0a3de9
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64
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Demonstration of binding induced structural plasticity in a sh2 domain, file e3835325-f7f4-15e8-e053-a505fe0a3de9
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60
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Fuzziness and frustration in the energy landscape of protein folding, function, and assembly, file e3835329-ed08-15e8-e053-a505fe0a3de9
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60
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Modulation of measles virus NTAIL interactions through fuzziness and sequence features of disordered binding sites, file e383531f-436b-15e8-e053-a505fe0a3de9
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59
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Folding mechanisms steer the amyloid fibril formation propensity of highly homologous proteins, file e383531a-cab9-15e8-e053-a505fe0a3de9
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55
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A structurally heterogeneous transition state underlies coupled binding and folding of disordered proteins, file e3835323-ca20-15e8-e053-a505fe0a3de9
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52
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Hidden kinetic traps in multidomain folding highlight the presence of a misfolded but functionally competent intermediate, file e3835327-b85d-15e8-e053-a505fe0a3de9
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49
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Anticancer activity of (S)-5-Chloro-3-((3,5-dimethylphenyl)sulfonyl)-N-(1-oxo-1-((pyridin-4-ylmethyl)amino)propan-2-yl)-1H-indole-2-carboxamide (RS4690), a new dishevelled 1 inhibitor, file e383532e-2da4-15e8-e053-a505fe0a3de9
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49
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Supertertiary protein structure affects an allosteric network, file e3835328-87f1-15e8-e053-a505fe0a3de9
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46
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Unveiling induced folding of intrinsically disordered proteins - Protein engineering, frustration and emerging themes, file e383532d-835e-15e8-e053-a505fe0a3de9
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44
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Determining folding and binding properties of the C-terminal SH2 domain of SHP2, file e383532d-49f6-15e8-e053-a505fe0a3de9
|
30
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Targeting PDZ domains as potential treatment for viral infections, neurodegeneration and cancer, file e383532d-208c-15e8-e053-a505fe0a3de9
|
29
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The cooperative folding of annexin A2 relies on a transient nonnative intermediate, file 960327a6-447d-49ce-8d46-c262d40811b9
|
24
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Characterization of early and late transition states of the folding pathway of a SH2 domain, file e383532f-3559-15e8-e053-a505fe0a3de9
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24
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Exploring the effect of tethered domains on the folding of Grb2 protein, file e7aa879b-332c-40c7-8b60-aff26431037c
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24
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On the effects of disordered tails, supertertiary structure and quinary interactions on the folding and function of protein domains, file e383532e-5251-15e8-e053-a505fe0a3de9
|
15
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Characterization of human frataxin missense variants in cancer tissues, file e383532b-70cd-15e8-e053-a505fe0a3de9
|
13
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Folding and binding mechanisms of the SH2 domain from Crkl, file f00e2e41-3516-4b00-84cd-08c701874b36
|
13
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Allostery frustrates the experimentalist, file 775ee274-66ec-4f63-9b90-cc3ea4cb9fda
|
12
|
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Characterization of the folding and binding properties of the PTB domain of FRS2 with phosphorylated and unphosphorylated ligands, file c1784792-171a-463c-bb84-eb6f8f5dad8c
|
12
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Biophysical characterization of the binding mechanism between the MATH domain of SPOP and its physiological partners, file c58b446d-33ff-4cab-8ef2-b495f03ac742
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12
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Experimental characterization of the interaction between the n-terminal sh3 domain of crkl and c3g, file e383532d-cb1e-15e8-e053-a505fe0a3de9
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12
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Understanding the molecular basis of folding cooperativity through a comparative analysis of a multidomain protein and its isolated domains, file 2c05d229-c23b-48bc-94b1-faacd91e709f
|
10
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An intramolecular energetic network regulates ligand recognition in a SH2 domain, file e264e4a9-10ca-4fa0-bffe-3619fc45416d
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10
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Addressing the binding mechanism of the Meprin and TRAF-C hmology domain of the Speckle-Type POZ protein using protein engineering, file d63a2ebd-ae17-45d3-9b80-ac4e594ca317
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4
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Cryptic binding properties of a transient folding intermediate in a PDZ tandem repeat, file d7395b11-d096-443f-bfec-82b496fb2da5
|
4
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Tolerance of protein folding to a circular permutation in a PDZ domain., file e3835312-c32a-15e8-e053-a505fe0a3de9
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4
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A carboxylate to amide substitution that switches protein folds, file e383531c-63d6-15e8-e053-a505fe0a3de9
|
4
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Characterization of human frataxin missense variants in cancer tissues, file e3835321-e507-15e8-e053-a505fe0a3de9
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4
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Demonstration of a folding after binding mechanism in the recognition between the measles virus NTAIL and X domains, file e3835312-bd52-15e8-e053-a505fe0a3de9
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3
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Coupled binding and folding of intrinsically disordered proteins: what can we learn from kinetics?, file e3835314-7a99-15e8-e053-a505fe0a3de9
|
3
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Mutational analysis of the binding-induced folding reaction of the mixed-lineage leukemia protein to the KIX domain., file e3835316-9559-15e8-e053-a505fe0a3de9
|
3
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Molecular recognition by templated folding of an intrinsically disordered protein, file e3835316-b19b-15e8-e053-a505fe0a3de9
|
3
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Activation barrier-limited folding and conformational sampling of a dynamic protein domain, file e3835316-b331-15e8-e053-a505fe0a3de9
|
3
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Understanding the role of phosphorylation in the binding mechanism of a PDZ domain, file e3835317-1243-15e8-e053-a505fe0a3de9
|
3
|
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Sequence-specific long range networks in PSD-95/discs large/ZO-1 (PDZ) domains tune their binding selectivity., file e3835319-d0cc-15e8-e053-a505fe0a3de9
|
3
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Targeting the Grb2 cSH3 domain: design, synthesis and biological evaluation of the first series of modulators, file a1266567-afef-4c80-bd57-7b2f43f0a90f
|
2
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Ligand binding to the pdz domains of postsynaptic density protein 95, file e3835316-6f63-15e8-e053-a505fe0a3de9
|
2
|
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Protein folding: vexing debates on a fundamental problem, file e3835316-767f-15e8-e053-a505fe0a3de9
|
2
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Identification and structural characterization of an intermediate in the folding of the measles virus x domain, file e3835316-eb44-15e8-e053-a505fe0a3de9
|
2
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Molecular medicine - to be or not to be, file e3835317-0280-15e8-e053-a505fe0a3de9
|
2
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How order and disorder within paramyxoviral nucleoproteins and phosphoproteins orchestrate the molecular interplay of transcription and replication, file e3835318-1e86-15e8-e053-a505fe0a3de9
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2
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Analyzing the folding and binding steps of an intrinsically disordered protein by protein engineering, file e3835318-25f8-15e8-e053-a505fe0a3de9
|
2
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Partner-mediated polymorphism of an intrinsically disordered protein, file e383531a-e06e-15e8-e053-a505fe0a3de9
|
2
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Stability of an aggregation-prone partially folded state of human profilin-1 correlates with aggregation propensity, file e383531c-71fb-15e8-e053-a505fe0a3de9
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2
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The folding mechanism of the SH3 domain from Grb2, file e383531f-1c8d-15e8-e053-a505fe0a3de9
|
2
|
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Mechanism of folding and binding of the n-terminal SH2 domain from SHP2, file e383531f-4370-15e8-e053-a505fe0a3de9
|
2
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The folding pathway of the KIX domain, file e3835321-9f53-15e8-e053-a505fe0a3de9
|
2
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Structural characterization of an on-pathway intermediate and transition state in the folding of the N-terminal SH2 domain from SHP2, file e3835323-b449-15e8-e053-a505fe0a3de9
|
2
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Binding induced folding: Lessons from the kinetics of interaction between NTAIL and XD, file e3835323-b44b-15e8-e053-a505fe0a3de9
|
2
|
|
Design, synthesis and biological evaluation of PDZ1 targeting NHERF1 inhibitors as anticancer agents, file e3835324-0461-15e8-e053-a505fe0a3de9
|
2
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|
Comparing the binding properties of peptides mimicking the envelope protein of sars-cov and sars-cov-2 to the pdz domain of the tight junction-associated pals1 protein, file e3835327-a56a-15e8-e053-a505fe0a3de9
|
2
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Probing the effects of local frustration in the folding of a multidomain protein, file e383532c-a5dc-15e8-e053-a505fe0a3de9
|
2
|
|
Exploring the short linear motif-mediated protein-protein interactions of CrkL through ProP-PD, file f92730dc-5a85-4d49-b081-811f87cf05fe
|
2
|
|
An Outlook on the Complexity of Protein Morphogenesis in Health and Disease, file 011cfc15-7c1b-465d-b8d5-c4aa3a181f1e
|
1
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A short structural extension dictates the early stages of folding of a PDZ domain, file 170e228e-d6e7-4f84-824f-541e7892f596
|
1
|
|
Exploring the cytochrome c folding: cyt c552 from Thermus Thermopilus folds through and on-pathway intermediate, file e3835311-b5d2-15e8-e053-a505fe0a3de9
|
1
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|
A complex equilibrium among partially unfolded conformations in monomeric transthyretin., file e3835312-c146-15e8-e053-a505fe0a3de9
|
1
|
|
Understanding the effect of alternative splicing in the folding and function of the second pdz from protein tyrosine phosphatase-bl, file e3835312-c2e0-15e8-e053-a505fe0a3de9
|
1
|
|
GB1 Is Not a Two-State Folder: Identification and Characterization of an On-Pathway Intermediate, file e3835312-c6a3-15e8-e053-a505fe0a3de9
|
1
|
|
Frustration sculpts the early stages of protein folding, file e3835314-812b-15e8-e053-a505fe0a3de9
|
1
|
|
Structural characterization of the early events in the nucleation− condensation mechanism in a protein folding process, file e3835318-6543-15e8-e053-a505fe0a3de9
|
1
|
|
How Robust Is the Mechanism of Folding-Upon-Binding for an Intrinsically Disordered Protein?, file e383531a-e12c-15e8-e053-a505fe0a3de9
|
1
|
|
Understanding intramolecular crosstalk in an intrinsically disordered protein, file e3835323-8840-15e8-e053-a505fe0a3de9
|
1
|
|
Templated folding of intrinsically disordered proteins, file e3835327-4426-15e8-e053-a505fe0a3de9
|
1
|
|
Understanding binding-induced folding by temperature jump, file e3835328-1795-15e8-e053-a505fe0a3de9
|
1
|
|
Folding and misfolding of a PDZ tandem repeat, file e3835329-a391-15e8-e053-a505fe0a3de9
|
1
|
| Totale |
2.697 |