DI MARCOTULLIO, LUCIA
 Distribuzione geografica
Continente #
NA - Nord America 4.850
EU - Europa 2.228
AS - Asia 531
AF - Africa 42
SA - Sud America 30
OC - Oceania 6
Totale 7.687
Nazione #
US - Stati Uniti d'America 4.814
IT - Italia 1.092
SE - Svezia 349
DE - Germania 247
IN - India 212
CN - Cina 153
FI - Finlandia 110
SG - Singapore 98
AT - Austria 92
RO - Romania 71
UA - Ucraina 65
GB - Regno Unito 39
BG - Bulgaria 38
CA - Canada 31
TG - Togo 30
FR - Francia 25
IE - Irlanda 23
AR - Argentina 22
CH - Svizzera 18
BE - Belgio 17
HK - Hong Kong 17
TW - Taiwan 16
ES - Italia 9
CZ - Repubblica Ceca 8
ZA - Sudafrica 8
NL - Olanda 7
TR - Turchia 7
HR - Croazia 6
JP - Giappone 5
RU - Federazione Russa 5
KZ - Kazakistan 4
MX - Messico 4
PK - Pakistan 4
AU - Australia 3
BR - Brasile 3
CL - Cile 3
IR - Iran 3
MY - Malesia 3
NZ - Nuova Zelanda 3
BD - Bangladesh 2
EE - Estonia 2
PE - Perù 2
SC - Seychelles 2
BS - Bahamas 1
EG - Egitto 1
GE - Georgia 1
GR - Grecia 1
HU - Ungheria 1
ID - Indonesia 1
KG - Kirghizistan 1
KR - Corea 1
LA - Repubblica Popolare Democratica del Laos 1
LT - Lituania 1
LV - Lettonia 1
MA - Marocco 1
PT - Portogallo 1
UZ - Uzbekistan 1
VN - Vietnam 1
Totale 7.687
Città #
Fairfield 763
Rome 527
Chandler 449
Ashburn 423
Seattle 375
Woodbridge 365
Houston 286
Cambridge 252
Wilmington 241
Ann Arbor 179
Dearborn 125
San Paolo di Civitate 114
Princeton 107
Lawrence 89
Grafing 84
Vienna 83
New York 82
Beijing 78
Plano 73
Fremont 64
San Diego 63
Millbury 53
Bremen 51
Boston 48
Timisoara 44
Helsinki 43
Sofia 38
Andover 30
Lomé 30
Singapore 25
Milan 23
Des Moines 22
Dublin 22
Federal 22
Jacksonville 18
Phoenix 17
Hong Kong 16
Norwalk 16
Siena 16
Boardman 15
Kaohsiung City 15
Toronto 14
Brussels 12
Redwood City 12
Kunming 11
Fiuggi 10
Falls Church 9
Nanjing 9
Bühl 8
Prague 8
Pune 8
Washington 8
Hefei 7
Ottawa 7
Velletri 7
Fasano 6
Florence 6
Istanbul 6
San Benedetto del Tronto 6
San Mateo 6
Senigallia 6
Torino 6
Trieste 6
Verona 6
Zagreb 6
Centrale 5
Los Angeles 5
Naples 5
Nürnberg 5
Palermo 5
Pomezia 5
Arezzo 4
Cerveteri 4
Chongqing 4
Denver 4
Guangzhou 4
Hebei 4
Leuven 4
London 4
Luzern 4
Miglianico 4
Muizenberg 4
Nanchang 4
Notre Dame 4
Pescara 4
Sacramento 4
Auckland 3
Berlin 3
Bethesda 3
Castelnuovo di Val di Cecina 3
Chiswick 3
Gunzenhausen 3
Indiana 3
Menlo Park 3
Minturno 3
Montreal 3
Montréal 3
Padova 3
Paris 3
Parma 3
Totale 5.708
Nome #
β-arrestin1-mediated acetylation of Gli1 regulates Hedgehog/Gli signaling and modulates self-renewal of SHH medulloblastoma cancer stem cells 155
New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer 130
A Smo/Gli multitarget hedgehog pathway inhibitor impairs tumor growth 130
Mitogen-activated kinase kinase kinase 1 inhibits hedgehog signaling and medulloblastoma growth through GLI1 phosphorylation 128
Non-canonical Hedgehog/ampk-mediated control of polyamine metabolism supports neuronal and medulloblastoma cell growth 128
ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP 122
1H-NMR metabolomics reveals the Glabrescione B exacerbation of glycolytic metabolism beside the cell growth inhibitory effect in glioma 119
Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype 118
Hedgehog antagonist REN(KCTD11) regulates proliferation and apoptosis of developing granule cell progenitors. 115
Glabrescione B delivery by self-assembling micelles efficiently inhibits tumor growth in preclinical models of Hedgehog-dependent medulloblastoma 112
Targeting GLI factors to inhibit the Hedgehog pathway 109
Noncanonical GLI1 signaling promotes stemness features and in vivo growth in lung adenocarcinoma 109
Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis 108
The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress 105
Maml1 acts cooperatively with Gli proteins to regulate Sonic hedgheog signaling pathway 104
The energy sensor AMPK regulates Hedgehog signaling in human cells through a unique Gli1 metabolic checkpoint 104
Design, palladium-catalyzed synthesis, and biological investigation of 2-substituted 3-aroylquinolin-4(1H)-ones as inhibitors of the Hedgehog signaling pathway. 103
Kras/ADAM17-dependent Jag1-ICD reverse signalling sustains CRC progression and chemoresistance 103
Turning off the switch in medulloblastoma. The inhibitory acetylation of an oncogene 102
Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma. 98
KCTD15 inhibits the Hedgehog pathway in Medulloblastoma cells by increasing protein levels of the oncosuppressor KCASH2 98
Phenformin inhibits hedgehog-dependent tumor growth through a complex i-independent redox/corepressor module 97
Histone deacetylase and Cullin3-REN KCTD11 ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation 95
Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold 94
Downregulation of miR-326 and its host gene β-arrestin1 induces pro survival activity of E2F1 and promotes medulloblastoma growth 94
Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold 91
Chromosome 17p Deletion in Human Medulloblastoma: A Missing Checkpoint in the Hedgehog Pathway 90
Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors 88
Digging a hole under Hedgehog: Downstream inhibition as an emerging anticancer strategy 87
MRE11 inhibition highlights a replication stress-dependent vulnerability of MYCN-driven tumors 86
Identification and Characterization of KCASH2 and KCASH3, 2 Novel Cullin3 Adaptors Suppressing Histone Deacetylase and Hedgehog Activity in Medulloblastoma 86
Cullin3-BTB interface: a novel target for stapled peptides 85
Changing nucleosome positions through the modification of the DNA rotational information. 84
Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61 84
Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation 84
Notch3/Jagged1 Circuitry Reinforces Notch Signaling and Sustains T-ALL. 84
Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation 83
Changing nucleosome positions through modification of the DNA rotational information 82
microRNA-17-92 cluster is a direct Nanog target and controls neural stem cell through Trp53inp1 81
MK-4101 - a potent inhibitor of the hedgehog pathway - is highly active against medulloblastoma and basal cell carcinoma 81
Thrombospondin-1 is a mediator of the neurotypic differentiation induced by EGF in thymic epithelial cells 80
Druggable glycolytic requirement for Hedgehog-dependent neuronal and medulloblastoma growth 79
Insights into gli factors ubiquitylation methods 78
Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells 78
Hypomorphic Recessive Variants in SUFU Impair the Sonic Hedgehog Pathway and Cause Joubert Syndrome with Cranio-facial and Skeletal Defects 77
Hedgehog controls neural stem cells through p53-independent regulation of Nanog 76
Alternative splicing of the ErbB-4 cytoplasmic domain and its regulation by hedgehog signaling identify distinct medulloblastoma subsets 75
SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development 75
EGF- and cell-cycle-regulated STAG1/PMEPA1 ERG1.2 belongs to a conserved gene family and is overexpressed and amplified in breast and ovarian cancer 75
Protected from the inside: Endogenous histone deacetylase inhibitors and the road to cancer 74
Numb-dependent integration of pre-TCR and p53 function in T-cell precursor development. 74
Multitarget hedgehog pathway inhibitors and uses thereof 74
MicroRNA profiling in human medulloblastoma 73
Hedgehog/Gli Control by Ubiquitination/Acetylation Interplay 73
P300/CBP-associated factor regulates transcription and function of isocitrate dehydrogenase 2 during muscle differentiation 73
An integrated approach identifies Nhlh1 and Insm1 as Sonic Hedgehog-regulated genes in developing cerebellum and medulloblastoma 73
P27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis 72
Multiple ubiquitin-dependent processing pathways regulate hedgehog/gli signaling: implications for cell development and tumorigenesis. 72
Changing nucleosome positions in vivo through modification of the DNA rotational information 72
ERAP1 as an emerging therapeutic target for medulloblastoma 72
PCAF ubiquitin ligase activity inhibits Hedgehog/Gli1 signaling in p53-dependent response to genotoxic stress 69
Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch- dependent ubiquitination 68
Targeting hedgehog signalling through the ubiquitylation process: the multiple roles of the HECT-E3 ligase itch 68
REN KCTD11 is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma. 67
Expression of the HMGI(Y) gene products in human neuroblastic tumors correlates with differentiation status 66
Design and synthesis of new withaferin A inspired hedgehog pathway inhibitors 66
The interplay between microRNAs and the neurotrophin receptor tropomyosin-related kinase C controls proliferation of human neuroblastoma cells 66
New Pyrrole Derivatives with Potent Tubulin Polymerization Inhibiting Activity As Anticancer Agents Including Hedgehog-Dependent Cancer 66
EGF regulates a complex pattern of gene expression and represses smooth muscle differentiation during the neurotypic conversion of the neural-crest-derived TC-1S cell line 65
Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold 65
2-Aminopurine unravels a role for pRB in the regulation of gene expression by transforming growth factor beta. 64
Yin-Yang strands of PCAF/Hedgehog axis in cancer control 64
HMGA molecules in neuroblastic tumors 64
The growth arrest and downregulation of c-myc transcription induced by ceramide are related events dependent on p21 induction, Rb underphosphorylation and E2F sequestering. 64
Hedgehog signaling pathway in neural development and disease 64
Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal 63
Nutlin-3a enhances natural killer cell-mediated killing of neuroblastoma by restoring p53-dependent expression of ligands for NKG2D and DNAM-1 receptors 63
Gli2 Acetylation at Lysine 757 Regulates Hedgehog-Dependent Transcriptional Output by Preventing Its Promoter Occupancy 62
Molecular organization of the cullin E3 ligase adaptor KCTD11 61
The rna-binding ubiquitin ligase mex3a affects glioblastoma tumorigenesis by inducing ubiquitylation and degradation of rig-i 61
The E3 ligase Aip4/Itch ubiquitinates and targets ErbB-4 for degradation 59
Discovery, characterization and potential roles of a novel NF-YAx splice variant in human neuroblastoma 59
SALL4 is a CRL3^REN/KCTD11 substrate that drives Sonic Hedgehog-dependent medulloblastoma 58
Hedgehog signaling pathway inhibitors: an updated patent review (2015–present) 58
Hedgehog checkpoints in medulloblastoma: the chromosome 17p-deletion paradigm. 55
CNBP regulates wing development in Drosophila melanogaster by promoting IRES-dependent translation of dMyc 55
A gene dosage‐dependent effect unveils NBS1 as both a haploinsufficient tumour suppressor and an essential gene for SHH‐medulloblastoma 52
Corrigendum: Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma 51
Drug delivery systems for hedgehog inhibitors in the treatment of SHH-medulloblastoma 50
Dual smo/braf inhibition by flavonolignans from silybum marianum 48
Harnessing the activation of RIG-I like receptors to inhibit glioblastoma tumorigenesis 47
mPEG5kDa-cholane/Glabrescione B delivery system as promising tool for the treatment of Hh-dependent tumors 45
The multiple functions of Numb. 44
Dubs activating the hedgehog signaling pathway: a promising therapeutic target in cancer 44
Oncogenic role of the ubiquitin ligase subunit Skp2 in human cancer 42
Proteolysis-Targeting Chimera (PROTAC): Is the Technology Looking at the Treatment of Brain Tumors? 42
The SHH/GLI signaling pathway: a therapeutic target for medulloblastoma 41
Suppressors of Hedgehog signalling: linking aberrant development of neural progenitors to tumorigenesis. 40
GLI1-selective inhibitor, Glabrescione B, impairs proliferation in intrahepatic cholangiocarcinoma 38
Nuclear Factor of Activated T Cells-dependent Down-regulation of the Transcription Factor Glioma-associated Protein 1 (GLI1) Underlies the Growth Inhibitory Properties of Arachidonic Acid 38
Totale 7.813
Categoria #
all - tutte 20.152
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 222
selected - selezionate 0
volume - volumi 0
Totale 20.374


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019491 0 0 0 0 0 0 0 0 0 0 280 211
2019/20201.700 180 50 28 68 167 241 272 208 185 148 84 69
2020/2021886 58 67 30 35 25 82 76 48 106 260 66 33
2021/20221.457 110 76 102 157 137 45 33 146 108 100 252 191
2022/20231.735 249 376 98 241 184 168 45 103 151 24 56 40
2023/20241.062 52 87 57 60 117 293 59 143 18 124 52 0
Totale 8.028