PCAF (p300/CBP associated factor) harbors acetyltransferase and a recently identified ubiquitylation activity that regulates gene expression in response to genotoxic stress or mitogenic signals. We highlight the dual role of PCAF in the control of Hedgehog signaling, a master regulator of tissue development, stemness, and tumorigenesis. By promoting histone acetylation at Hedgehog/GLI1 target gene promoters or direct ubiquitylation and proteolysis of GLI1, the PCAF/GLI1 axis stands as a promising therapeutic target for Hedgehog-dependent tumors. © 2014 Elsevier Ltd.
Yin-Yang strands of PCAF/Hedgehog axis in cancer control / Infante, Paola; Canettieri, Gianluca; Gulino, Alberto; DI MARCOTULLIO, Lucia. - In: TRENDS IN MOLECULAR MEDICINE. - ISSN 1471-4914. - 20:8(2014), pp. 416-418. [10.1016/j.molmed.2014.05.003]
Yin-Yang strands of PCAF/Hedgehog axis in cancer control
INFANTE, PAOLA;CANETTIERI, Gianluca;GULINO, Alberto;DI MARCOTULLIO, LUCIA
2014
Abstract
PCAF (p300/CBP associated factor) harbors acetyltransferase and a recently identified ubiquitylation activity that regulates gene expression in response to genotoxic stress or mitogenic signals. We highlight the dual role of PCAF in the control of Hedgehog signaling, a master regulator of tissue development, stemness, and tumorigenesis. By promoting histone acetylation at Hedgehog/GLI1 target gene promoters or direct ubiquitylation and proteolysis of GLI1, the PCAF/GLI1 axis stands as a promising therapeutic target for Hedgehog-dependent tumors. © 2014 Elsevier Ltd.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
