| Nome |
# |
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Targeting GLI factors to inhibit the Hedgehog pathway, file e3835314-c0cb-15e8-e053-a505fe0a3de9
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409
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New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer, file e3835314-1399-15e8-e053-a505fe0a3de9
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369
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Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold, file e383531b-2db6-15e8-e053-a505fe0a3de9
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330
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Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype, file e3835315-822b-15e8-e053-a505fe0a3de9
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198
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Nutlin-3a enhances natural killer cell-mediated killing of neuroblastoma by restoring p53-dependent expression of ligands for NKG2D and DNAM-1 receptors, file e3835328-e248-15e8-e053-a505fe0a3de9
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198
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ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP, file e3835322-c3c6-15e8-e053-a505fe0a3de9
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184
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The MRN complex is transcriptionally regulated by MYCN during neural cell proliferation to control replication stress, file e3835313-1a0a-15e8-e053-a505fe0a3de9
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129
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Targeting hedgehog signalling through the ubiquitylation process: the multiple roles of the HECT-E3 ligase itch, file e3835323-769c-15e8-e053-a505fe0a3de9
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129
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1H-NMR metabolomics reveals the Glabrescione B exacerbation of glycolytic metabolism beside the cell growth inhibitory effect in glioma, file e3835324-64ee-15e8-e053-a505fe0a3de9
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129
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β-arrestin1-mediated acetylation of Gli1 regulates Hedgehog/Gli signaling and modulates self-renewal of SHH medulloblastoma cancer stem cells, file e3835318-cb1c-15e8-e053-a505fe0a3de9
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127
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Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis, file e3835319-da54-15e8-e053-a505fe0a3de9
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124
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Noncanonical GLI1 signaling promotes stemness features and in vivo growth in lung adenocarcinoma, file e383531d-1dc5-15e8-e053-a505fe0a3de9
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122
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The rna-binding ubiquitin ligase mex3a affects glioblastoma tumorigenesis by inducing ubiquitylation and degradation of rig-i, file e3835325-7705-15e8-e053-a505fe0a3de9
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119
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The energy sensor AMPK regulates Hedgehog signaling in human cells through a unique Gli1 metabolic checkpoint, file e3835314-8184-15e8-e053-a505fe0a3de9
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114
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Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma., file e3835317-00e2-15e8-e053-a505fe0a3de9
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113
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A Smo/Gli multitarget hedgehog pathway inhibitor impairs tumor growth, file e3835323-769e-15e8-e053-a505fe0a3de9
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110
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SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development, file e3835316-0bc3-15e8-e053-a505fe0a3de9
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107
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MRE11 inhibition highlights a replication stress-dependent vulnerability of MYCN-driven tumors, file e383531e-6ac9-15e8-e053-a505fe0a3de9
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99
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KCTD15 inhibits the Hedgehog pathway in Medulloblastoma cells by increasing protein levels of the oncosuppressor KCASH2, file e3835323-f6cd-15e8-e053-a505fe0a3de9
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90
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Maml1 acts cooperatively with Gli proteins to regulate Sonic hedgheog signaling pathway, file e3835319-b04f-15e8-e053-a505fe0a3de9
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89
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Discovery, characterization and potential roles of a novel NF-YAx splice variant in human neuroblastoma, file e3835324-739d-15e8-e053-a505fe0a3de9
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88
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Phenformin inhibits hedgehog-dependent tumor growth through a complex i-independent redox/corepressor module, file e3835324-ff9f-15e8-e053-a505fe0a3de9
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79
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The SHH/GLI signaling pathway: a therapeutic target for medulloblastoma, file e383532c-84ab-15e8-e053-a505fe0a3de9
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74
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Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors, file e3835312-4876-15e8-e053-a505fe0a3de9
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70
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Glabrescione B delivery by self-assembling micelles efficiently inhibits tumor growth in preclinical models of Hedgehog-dependent medulloblastoma, file e3835328-eb23-15e8-e053-a505fe0a3de9
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65
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Turning off the switch in medulloblastoma. The inhibitory acetylation of an oncogene, file e3835324-5470-15e8-e053-a505fe0a3de9
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63
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MK-4101 - a potent inhibitor of the hedgehog pathway - is highly active against medulloblastoma and basal cell carcinoma, file e3835326-7f81-15e8-e053-a505fe0a3de9
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61
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Downregulation of miR-326 and its host gene β-arrestin1 induces pro survival activity of E2F1 and promotes medulloblastoma growth, file e3835328-06b7-15e8-e053-a505fe0a3de9
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58
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Mitogen-activated kinase kinase kinase 1 inhibits hedgehog signaling and medulloblastoma growth through GLI1 phosphorylation, file e383532b-9064-15e8-e053-a505fe0a3de9
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52
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Nuclear Factor of Activated T Cells-dependent Down-regulation of the Transcription Factor Glioma-associated Protein 1 (GLI1) Underlies the Growth Inhibitory Properties of Arachidonic Acid, file e3835315-bc09-15e8-e053-a505fe0a3de9
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48
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Dual smo/braf inhibition by flavonolignans from silybum marianum, file e383532c-a42d-15e8-e053-a505fe0a3de9
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48
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Downregulation of miR-326 and its host gene β-arrestin1 induces pro survival activity of E2F1 and promotes medulloblastoma growth, file e3835329-18da-15e8-e053-a505fe0a3de9
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47
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Cullin3-BTB interface: a novel target for stapled peptides, file e383532e-408a-15e8-e053-a505fe0a3de9
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46
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Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation, file e3835329-0a3c-15e8-e053-a505fe0a3de9
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41
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Corrigendum: Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma, file e383532d-87ba-15e8-e053-a505fe0a3de9
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34
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KCTD1 is a new modulator of the KCASH family of Hedgehog suppressors, file 651d9fb0-22fa-4ca1-930e-28313e7c01b2
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22
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Dubs activating the hedgehog signaling pathway: a promising therapeutic target in cancer, file e383532c-93fc-15e8-e053-a505fe0a3de9
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20
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A new smoothened antagonist bearing the purine scaffold shows antitumour activity in vitro and in vivo, file e383532d-f711-15e8-e053-a505fe0a3de9
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19
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Design and synthesis of new withaferin A inspired hedgehog pathway inhibitors, file e383532e-9365-15e8-e053-a505fe0a3de9
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18
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Drug delivery systems for hedgehog inhibitors in the treatment of SHH-medulloblastoma, file e383532e-520c-15e8-e053-a505fe0a3de9
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17
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SMA-miRs (MiR-181a- 5p, -324-5p, and -451a) are overexpressed in spinal muscular atrophy skeletal muscle and serum samples, file e383532e-520b-15e8-e053-a505fe0a3de9
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16
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Harnessing the activation of RIG-I like receptors to inhibit glioblastoma tumorigenesis, file e383532e-970e-15e8-e053-a505fe0a3de9
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16
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ERAP1 as an emerging therapeutic target for medulloblastoma, file e383532d-f70e-15e8-e053-a505fe0a3de9
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13
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Thrombospondin-1 is a mediator of the neurotypic differentiation induced by EGF in thymic epithelial cells, file e3835311-9ed0-15e8-e053-a505fe0a3de9
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6
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Design, palladium-catalyzed synthesis, and biological investigation of 2-substituted 3-aroylquinolin-4(1H)-ones as inhibitors of the Hedgehog signaling pathway., file e383531d-c1a3-15e8-e053-a505fe0a3de9
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6
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Kras/ADAM17-dependent Jag1-ICD reverse signalling sustains CRC progression and chemoresistance, file e3835323-5f7e-15e8-e053-a505fe0a3de9
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6
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Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation, file 96008b0d-a210-45cd-b987-beb49d2248bd
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4
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Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61, file d26acd5c-3127-444f-b143-51c8ec31320d
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4
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Hedgehog signaling pathway inhibitors: an updated patent review (2015–present), file e3835325-7707-15e8-e053-a505fe0a3de9
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4
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Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold, file e383532c-8b2d-15e8-e053-a505fe0a3de9
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4
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Hedgehog controls neural stem cells through p53-independent regulation of Nanog, file e3835311-7577-15e8-e053-a505fe0a3de9
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3
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Non-canonical Hedgehog/ampk-mediated control of polyamine metabolism supports neuronal and medulloblastoma cell growth, file e3835313-2cdf-15e8-e053-a505fe0a3de9
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3
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CNBP regulates wing development in Drosophila melanogaster by promoting IRES-dependent translation of dMyc, file e3835313-ba49-15e8-e053-a505fe0a3de9
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3
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Exploring the potential of anthraquinone-based hybrids for identifying a novel generation of antagonists for the Smoothened receptor in HH-dependent tumour, file db979285-ff8c-4b0c-8812-33f7653c5d1a
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2
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Digging a hole under Hedgehog: Downstream inhibition as an emerging anticancer strategy, file e3835313-2d59-15e8-e053-a505fe0a3de9
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2
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Insights into gli factors ubiquitylation methods, file e3835314-c6cd-15e8-e053-a505fe0a3de9
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2
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Hypomorphic Recessive Variants in SUFU Impair the Sonic Hedgehog Pathway and Cause Joubert Syndrome with Cranio-facial and Skeletal Defects, file e3835319-da55-15e8-e053-a505fe0a3de9
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2
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P300/CBP-associated factor regulates transcription and function of isocitrate dehydrogenase 2 during muscle differentiation, file e3835322-3dbc-15e8-e053-a505fe0a3de9
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2
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Kras/ADAM17-dependent Jag1-ICD reverse signalling sustains CRC progression and chemoresistance, file e383532a-72dd-15e8-e053-a505fe0a3de9
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2
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Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold, file e383532c-9839-15e8-e053-a505fe0a3de9
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2
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Proteolysis-Targeting Chimera (PROTAC): Is the Technology Looking at the Treatment of Brain Tumors?, file e383532e-b463-15e8-e053-a505fe0a3de9
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2
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A gene dosage‐dependent effect unveils NBS1 as both a haploinsufficient tumour suppressor and an essential gene for SHH‐medulloblastoma, file 5ba8a075-03d8-4c4c-b348-2b228fc87a15
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1
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SALL4 is a CRL3^REN/KCTD11 substrate that drives Sonic Hedgehog-dependent medulloblastoma, file 87ae5f63-35f2-48df-bd8d-0e1042b1706d
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1
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MicroRNA profiling in human medulloblastoma, file e3835311-882a-15e8-e053-a505fe0a3de9
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1
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Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch- dependent ubiquitination, file e3835311-a952-15e8-e053-a505fe0a3de9
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1
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Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells, file e3835311-c35b-15e8-e053-a505fe0a3de9
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1
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The interplay between microRNAs and the neurotrophin receptor tropomyosin-related kinase C controls proliferation of human neuroblastoma cells, file e3835311-c92f-15e8-e053-a505fe0a3de9
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1
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PCAF ubiquitin ligase activity inhibits Hedgehog/Gli1 signaling in p53-dependent response to genotoxic stress, file e3835311-d214-15e8-e053-a505fe0a3de9
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1
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Hedgehog antagonist REN(KCTD11) regulates proliferation and apoptosis of developing granule cell progenitors., file e3835312-24d3-15e8-e053-a505fe0a3de9
|
1
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| Totale |
4.371 |