Numb is an evolutionary conserved protein that plays critical roles in cell fate determination. Mammalian Numb displays a higher degree of structural complexity compared to the Drosophila homolog based on the number of encoding genes (Numb and Numb-like) and of alternative spliced isoforms. Accordingly, Numb proteins display a complex pattern of functions such as the control of asymmetric cell division and cell fate choice, endocytosis, cell adhesion, cell migration, ubiquitination of specific substrates and a number of signaling pathways (i.e. Notch, Hedgehog, p53). Recent findings indicate that, besides controlling such physiologic developmental processes, subversion of the above Numb-dependent events plays a critical role in disease (e.g. cancer). We will review here the multiple functions of mNumb and their underlying molecular mechanisms in development and disease.

The multiple functions of Numb / Gulino, Alberto; DI MARCOTULLIO, Lucia; Screpanti, Isabella. - In: EXPERIMENTAL CELL RESEARCH. - ISSN 0014-4827. - STAMPA. - 316:(2009), pp. 900-906. [10.1016/j.yexcr.2009.11.017]

The multiple functions of Numb.

GULINO, Alberto;DI MARCOTULLIO, LUCIA;SCREPANTI, Isabella
2009

Abstract

Numb is an evolutionary conserved protein that plays critical roles in cell fate determination. Mammalian Numb displays a higher degree of structural complexity compared to the Drosophila homolog based on the number of encoding genes (Numb and Numb-like) and of alternative spliced isoforms. Accordingly, Numb proteins display a complex pattern of functions such as the control of asymmetric cell division and cell fate choice, endocytosis, cell adhesion, cell migration, ubiquitination of specific substrates and a number of signaling pathways (i.e. Notch, Hedgehog, p53). Recent findings indicate that, besides controlling such physiologic developmental processes, subversion of the above Numb-dependent events plays a critical role in disease (e.g. cancer). We will review here the multiple functions of mNumb and their underlying molecular mechanisms in development and disease.
2009
01 Pubblicazione su rivista::01a Articolo in rivista
The multiple functions of Numb / Gulino, Alberto; DI MARCOTULLIO, Lucia; Screpanti, Isabella. - In: EXPERIMENTAL CELL RESEARCH. - ISSN 0014-4827. - STAMPA. - 316:(2009), pp. 900-906. [10.1016/j.yexcr.2009.11.017]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/132957
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