Endoplasmic reticulum aminopeptidase 1 (ERAP1) is a multifunctional enzyme that shapes the peptide repertoire presented by major histocompatibility complex class I (MHC-I) molecules, thereby affecting tumor immunogenicity. ERAP1 is altered in many tumors, including medulloblastoma (MB). We review the role of ERAP1 in MB development and the possibility of targeting this enzyme for MB treatment.
ERAP1 as an emerging therapeutic target for medulloblastoma / Bufalieri, F.; Fruci, D.; Di Marcotullio, L.. - In: TRENDS IN CANCER. - ISSN 2405-8033. - 8:1(2022), pp. 4-8. [10.1016/j.trecan.2021.09.005]
ERAP1 as an emerging therapeutic target for medulloblastoma
Bufalieri F.;Fruci D.;Di Marcotullio L.
2022
Abstract
Endoplasmic reticulum aminopeptidase 1 (ERAP1) is a multifunctional enzyme that shapes the peptide repertoire presented by major histocompatibility complex class I (MHC-I) molecules, thereby affecting tumor immunogenicity. ERAP1 is altered in many tumors, including medulloblastoma (MB). We review the role of ERAP1 in MB development and the possibility of targeting this enzyme for MB treatment.File allegati a questo prodotto
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
