CONTESTABILE, Roberto
 Distribuzione geografica
Continente #
NA - Nord America 5.540
EU - Europa 1.892
AS - Asia 673
AF - Africa 41
SA - Sud America 35
OC - Oceania 7
Totale 8.188
Nazione #
US - Stati Uniti d'America 5.044
IT - Italia 1.173
CA - Canada 450
IN - India 217
CN - Cina 202
SG - Singapore 164
SE - Svezia 134
FI - Finlandia 129
DE - Germania 103
UA - Ucraina 99
GB - Regno Unito 68
BZ - Belize 42
BG - Bulgaria 38
AR - Argentina 27
TG - Togo 25
FR - Francia 23
IE - Irlanda 23
TR - Turchia 21
HK - Hong Kong 20
BE - Belgio 17
NL - Olanda 15
CH - Svizzera 14
JP - Giappone 13
ZA - Sudafrica 13
ES - Italia 10
RO - Romania 9
RU - Federazione Russa 9
ID - Indonesia 8
PK - Pakistan 8
DK - Danimarca 7
KR - Corea 6
AT - Austria 5
NZ - Nuova Zelanda 5
CO - Colombia 4
IR - Iran 4
MX - Messico 4
PL - Polonia 4
AL - Albania 2
AU - Australia 2
BR - Brasile 2
CY - Cipro 2
CZ - Repubblica Ceca 2
LU - Lussemburgo 2
PT - Portogallo 2
SK - Slovacchia (Repubblica Slovacca) 2
TW - Taiwan 2
AE - Emirati Arabi Uniti 1
CL - Cile 1
DZ - Algeria 1
EE - Estonia 1
EG - Egitto 1
IL - Israele 1
MA - Marocco 1
MY - Malesia 1
NO - Norvegia 1
PE - Perù 1
PH - Filippine 1
TH - Thailandia 1
VN - Vietnam 1
Totale 8.188
Città #
Fairfield 690
Rome 470
Chandler 466
Ottawa 414
Ashburn 385
Woodbridge 314
Houston 276
Seattle 250
Ann Arbor 238
Dearborn 226
Cambridge 216
Wilmington 192
Princeton 130
San Jose 120
Plano 84
Beijing 82
San Paolo di Civitate 70
Lawrence 67
Fasano 59
Boston 57
Millbury 53
Milan 52
Helsinki 51
Las Vegas 48
San Diego 47
New York 46
Belize City 42
Buffalo 42
Falls Church 38
Sofia 38
Jacksonville 35
Andover 34
Washington 29
Shanghai 28
Lomé 25
Los Angeles 25
Norwalk 25
Singapore 25
Bremen 24
Dublin 23
Federal 23
Saint Louis 23
Fremont 22
Grafing 22
Des Moines 21
Redwood City 21
Toronto 21
Istanbul 20
Boardman 19
Chicago 16
Greater Noida 16
Albuquerque 15
Brussels 14
Naples 12
Parma 12
Hefei 11
Nanjing 11
Bühl 10
Florence 10
Hong Kong 10
Kunming 9
London 9
Columbus 8
Phoenix 8
Santa Clara 8
Surabaya 8
Weston-super-Mare 8
Edinburgh 7
Ferentino 7
Jinan 7
Mannheim 7
Cagliari 6
Muizenberg 6
San Mateo 6
Auckland 5
Berlin 5
Catania 5
Central 5
Decatur 5
Edmonton 5
Geneva 5
Lucknow 5
Moncalieri 5
Paris 5
Rieti 5
Buenos Aires 4
Casoria 4
Chions 4
Genoa 4
Indiana 4
Kennedy 4
Lahore 4
Modena 4
Moscow 4
Palermo 4
Philadelphia 4
Rochester 4
San Francisco 4
Tokyo 4
Turin 4
Totale 6.084
Nome #
PLP-dependent Enzymes: a Powerful Tool for Metabolic Synthesis of Non-canonical Amino Acids 340
The expression of four pyridoxal kinase (pdxk) human variants in drosophila impacts on genome integrity 149
Metodologie biochimiche. Espressione, purificazione e caratterizzazione delle proteine. Con espansione online 143
The moonlighting RNA-binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism 140
Differential 3-bromopyruvate inhibition of cytosolic and mitochondrial human serine hydroxymethyltransferase isoforms, key enzymes in cancer metabolic reprogramming 130
Human cytosolic and mitochondrial serine hydroxymethyltransferase isoforms in comparison: full kinetic characterization and substrate inhibition properties 129
Molecular basis of reduced pyridoxine 5'-phosphate oxidase catalytic activity in neonatal epileptic encephalopathy disorder. 126
Molecular mechanism of pdxr - a transcriptional activator involved in the regulation of vitamin b biosynthesis in the probiotic bacterium Bacillus clausii 122
Molecular mechanisms of the non-coenzyme action of thiamin in brain. Biochemical, structural and pathway analysis 116
Data from computational analysis of the peptide linkers in the mocr bacterial transcriptional regulators 114
Threonine aldolase and alanine racemase: novel examples of convergent evolution in the superfamily of vitamin B6-dependent enzymes 113
Pyridoxine-5'-phosphate oxidase (pnpo) deficiency. clinical and biochemical alterations associated with the c.347g>a (pp. arg116gln) mutation 113
Biochemical data from the characterization of a new pathogenic mutation of human pyridoxine-5'-phosphate oxidase (PNPO) 113
Screening and in vitro testing of antifolate inhibitors of human cytosolic serine hydroxymethyltransferase 112
A bioinformatics analysis reveals a group of MocR bacterial transcriptional regulators linked to a family of genes coding for membrane proteins 112
The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells 107
Pyridoxal 5’-Phosphate Enzymes as Targets for Therapeutic Agents. 106
Allosteric feedback inhibition of pyridoxine 5'-phosphate oxidase from escherichia coli 103
Biomedical aspects of pyridoxal 5’-phosphate availability 102
A comprehensive computational analysis of Mycobacterium genomes pinpoints the genes co-occurring with ycze, a membrane protein coding gene under the putative control of a mocr, and predicts its function 102
Isolation of a complex formed between acinetobacter baumannii hema and heml, key enzymes of tetrapyrroles biosynthesis 102
VITAMIN B(6) SALVAGE ENZYMES: MECHANISM, STRUCTURE AND REGULATION. 99
Asymmetry of the Active Site Loop Conformation between Subunits of Glutamate-1-semialdehyde Aminomutase in Solution 99
How pyridoxal 5'-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state 99
Study of DNA binding and bending by Bacillus subtilis GabR, a PLP-dependent transcription factor 98
Functional inactivation of drosophila GCK orthologs causes genomic instability and oxidative stress in a fly model of MODY-2 97
Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex 97
Pyridoxal 5’-Phosphate-Dependent Enzymes: Catalysis, Conformation and Genomics 94
Glycine consumption and mitochondrial serine hydroxymethyltransferase in cancer cells: the heme connection 93
Pyridoxal 5’-Phosphate is a Slow Tight Binding Inhibitor of E. coli Pyridoxal Kinase 92
Molecular basis of E. coli l-threonine aldolase catalytic inactivation at low pH 91
The MocR-like transcription factors: pyridoxal 5'-phosphate-dependent regulators of bacterial metabolism 90
Salmonella typhimurium PtsJ is a novel MocR-like transcriptional repressor involved in regulating the vitamin B6 salvage pathway 89
Role of a conserved active site cation-pi interaction in Escherichia coli serine hydroxymethyltransferase. 86
Corrigendum to “Pyridoxine-5′-phosphate oxidase (Pnpo) deficiency: Clinical and biochemical alterations associated with the C.347g > A (P.·Arg116gln) mutation” [Mol. Genet. Metab. 122/1–2 (2017) 135–142] 84
The mechanism of high-yielding chiral syntheses catalysed by wild-type and mutant forms of aspartate aminotransferase 83
Knowns and unknowns of vitamin B6 metabolism in escherichia coli 82
Structural stability of cold-adapted serine hydroxymethyltransferase, a tool for ß-hydroxy-α-amino acid biosynthesis 82
Structural stability of the cofactor binding site in Escherichia coli serine hydroxymethyltransferase--the role of evolutionarily conserved hydrophobic contacts. 81
In silico and in vitro validation of serine hydroxymethyltransferase as a chemotherapeutic target of the antifolate drug pemetrexed 81
Structural properties of the linkers connecting the n- and c- terminal domains in the mocr bacterial transcriptional regulators 81
Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex 80
Alanine racemase from Tolypocladium inflatum: A key PLP-dependent enzyme in cyclosporin biosynthesis and a model of catalytic promiscuity 79
Riboregulation as a new player in the control of cellular metabolism: clues from the cryo-EM structure of serine hydroxymethyltransferase-RNA complex 78
SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation 78
Structural and kinetic properties of serine hydroxymethyltransferase from the halophytic cyanobacterium aphanothece halophytica provide a rationale for salt tolerance 78
The aspartate aminotransferase-like domain of Firmicutes mocr transcriptional regulators 77
Differential inhibitory effect of a pyrazolopyran compound on human serine hydroxymethyltransferase-amino acid complexes 77
Mutation of tyrosine 332 to phenylalanine converts dopa decarboxylase into a decarboxylation-dependent oxidative deaminase 77
The crystal structure of archaeal serine hydroxymethyltransferase reveals idiosyncratic features likely required to withstand high temperatures 77
The contribution of a conformationally-mobile, active-site loop to the reaction catalysed by glutamate semialdehyde aminomutase 76
Inhibition of human pyridoxal kinase by 2-acetyl-4-((1R,2S,3R)-1,2,3,4-1 tetrahydroxybutyl)-imidazole (THI) 74
The multifaceted role of vitamin b6 in cancer: drosophila as a model system to investigate dna damage 74
Stereochemistry of the reactions of glutamate-1-semialdehyde aminomutase with 4,5-diaminovalerate 73
Identification and characterization of the pyridoxal 5'-phosphate allosteric site in Escherichia coli pyridoxine 5'-phosphate oxidase 73
On the mechanism of Escherichia coli pyridoxal kinase inhibition by pyridoxal and pyridoxal 5'-phosphate 73
Coupling bioorthogonal chemistries with artificial metabolism: Intracellular biosynthesis of azidohomoalanine and its incorporation into recombinant proteins 72
An engineered escherichia coli strain with synthetic metabolism for in‐cell production of translationally active methionine derivatives 72
Metodologie Biochimiche 71
Molecular Defects of Vitamin B6 Metabolism Associated with Neonatal Epileptic Encephalopathy 71
Editorial: PLP-dependent enzymes: extraordinary versatile catalysts and ideal biotechnological tools for the production of unnatural amino acids and related compounds 71
A pyrazolopyran derivative preferentially inhibits the activity of human cytosolic hydroxymethyltransferase and induces cell death in lung cancer cells 70
Interaction of Bacillus subtilis GabR with the gabTD promoter: role of repeated sequences and effect of GABA in transcriptional activation 70
Structure-Based Mechanism for Early PLP-Mediated Steps of Rabbit Cytosolic Serine Hydroxymethyltransferase Reaction 70
Role of Y65 and E57 in Escherichia coli serine hydroxymethyltransferase 69
The role of evolutionarily conserved hydrophobic contacts in the quaternary structure stability of Escherichia coli serine hydroxymethyltransferase 68
L-Threonine aldolase, serine hydroxymethyltransferase and fungal alanine racemase. A subsgroup of strictly related enzymes specialized for different functions 68
Reactions of glutamate semialdehyde aminotransferase (glutamate-1-semialdehyde 2,1 aminomutase) with vinyl and acetylenic substrate analogues analysed by rapid scanning spectrophotometry. 68
Vitamin B6 rescues insulin resistance and glucose-induced DNA damage caused by reduced activity of Drosophila PI3K 68
Metodologie biochimiche. Principi e tecniche per l'espressione, la purificazione e la caratterizzazione delle proteine 67
The reactions of glutamate semialdehyde aminomutase with (R) and (S)-enantiomers of a novel, mechanism-based inhibitor, 2, 3-diaminopropyl sulfate 67
Crystal Structures of Human Pyridoxal Kinase in Complex with the Neurotoxins, Ginkgotoxin and Theophylline: Insights into Pyridoxal Kinase Inhibition 67
Structural basis of methotrexate and pemetrexed action on serine hydroxymethyltransferases revealed using plant models 66
Molecular characterization of pyridoxine 5′-phosphate oxidase and its pathogenic forms associated with neonatal epileptic encephalopathy 66
THE CONTRIBUTION OF A CONFORMATIONALLY MOBILE ACTIVE SITE LOOP TO THE REACTION CATALYZED BY GLUTAMATE SEMIALDEYDE AMINOMUTASE 65
Serine hydroxymethyltransferase: role of the active site lysine in the mechanism of the enzyme. 65
Serine hydroxymethyltransferase: A model enzyme for mechanistic, structural, and evolutionary studies. 63
“L-Threonine aldolase, serine hydroxymethyltransferase and fungal alanine racemase. A subgroup of strictly related enzymes specialized for different functions”, in the 3rd International Symposium on Vitamin B6, PQQ, Carbonyl Catalysis and Quinoproteins, Southampton, United Kingdom, 14-19 April 2002. 63
On the catalytic mechanism and stereospecificity of Escherichia coli L-threonine aldolase 60
The Structure of Serine Hydroxymethyltransferase as modelled by Homology and validated by Site Directed Mutagenesis 57
Characterization of novel pathogenic variants causing pyridox(Am)ine 5′-phosphate oxidase-dependent epilepsy 54
Enzymatic synthesis of omega-carboxy-beta-hydroxy-(L)-alpha-amino acids 53
Crystal structure of glutamate-1-semialdehyde. An alpha-2-dimeric vitamin B6 dependent enzyme with asymmetry in structure and active site reactivity 51
COMUNICAZIONE ORALE A CONGRESSO SU INVITO “On the mechanism of addition of pyridoxal 5’-phosphate to serine hydroxymethyltransferase”, in The Third International Conference on Cofactors (ICC03), Finland, Turku, 10-15 July 2011. 51
PLP-dependent enzymes. 51
COMUNICAZIONE ORALE A CONGRESSO SU INVITO “Studies on the evolutionary origins of pyridoxal-phosphate-dependent enzymes: catalytic promiscuity and reaction specificity”, in “Quo Vadis Proteomics”, Napoli, 26 Marzo 2001. 50
A novel, easy assay method for human cysteine sulfinic acid decarboxylase 48
Thiamine-dependent regulation of mammalian brain pyridoxal kinase in vitro and in vivo 48
A gene-nutrient interaction between vitamin B6 and serine hydroxymethyltransferase (SHMT) affects genome integrity in Drosophila 44
BIOCHIMICA per Studenti di Scienze della Vita 44
Reactions of glutamate 1-semialdehyde aminomutase with R- and S-enantiomers of a novel, mechanism-based inhibitor, 2,3-diaminopropyl sulphate 43
Role of Tyrosine 65 in the mechanism of serine hydroxymethyltrasferase 43
The structure of serine hydrxymethyltransferase as modeled by homology and validated by site-directed mutagenesis 42
Isoforms of the DHTKD1-encoded 2-oxoadipate dehydrogenase, identified in animal tissues, are not observed upon the human DHTKD1 expression in bacterial or yeast systems 42
Metodologie biochimiche. Principi e tecniche per l'espressione, la purificazione e la caratterizzazione delle proteine 41
L-threonine aldolase, serine hydroxymethyltransferase and fungal alanine racemase: structural diversity and uniformity in a subgroup of closely related enzymes catalysing different reactions 41
THE STRUCTURE OF SERINE HYDROXYMETHYLTRANSFERASE MODELLED BY HOMOLOGY AND VALIDATED BY SITE DIRECTED MUTAGENESIS 41
Catalytic and thermodynamic properties of tetrahydromethanopterin-dependent serine hydroxymethyltransferase from Methanococcus jannaschii. 40
Pha-680626 is an effective inhibitor of the interaction between aurora-a and n-myc 40
COMUNICAZIONE ORALE A CONGRESSO SU INVITO “Asymmetric reactivity of glutamate semialdehyde aminomutase with cyanoborohydride” in the European meeting on pyridoxal phosphate-dependent enzymes, Basel, Switzerland, 20-23 September 1997. 38
Totale 8.155
Categoria #
all - tutte 20.676
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 381
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 21.057


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019442 0 0 0 0 0 0 0 0 0 0 249 193
2019/20201.520 167 47 22 101 134 277 224 156 145 95 95 57
2020/20211.051 66 51 29 206 81 53 8 86 124 193 115 39
2021/20221.985 53 203 133 52 241 80 75 405 171 98 235 239
2022/20231.604 231 257 77 276 198 160 24 97 133 29 74 48
2023/20241.268 63 107 134 260 116 184 55 142 22 129 56 0
Totale 8.607