Catalogo dei prodotti della ricerca

CONTESTABILE, Roberto
 Distribuzione geografica
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Continente #
NA - Nord America 5.697
EU - Europa 2.297
AS - Asia 994
AF - Africa 44
SA - Sud America 35
OC - Oceania 7
Totale 9.074
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Nazione #
US - Stati Uniti d'America 5.197
IT - Italia 1.430
CA - Canada 453
SG - Singapore 384
CN - Cina 259
IN - India 220
FI - Finlandia 151
SE - Svezia 138
DE - Germania 131
UA - Ucraina 99
GB - Regno Unito 80
FR - Francia 43
BZ - Belize 42
ID - Indonesia 39
BG - Bulgaria 38
BE - Belgio 33
RU - Federazione Russa 28
AR - Argentina 27
IE - Irlanda 27
TG - Togo 25
NL - Olanda 24
HK - Hong Kong 22
TR - Turchia 21
JP - Giappone 16
CH - Svizzera 15
ZA - Sudafrica 15
ES - Italia 13
KR - Corea 10
DK - Danimarca 9
RO - Romania 9
PK - Pakistan 8
AT - Austria 7
PL - Polonia 6
MX - Messico 5
NZ - Nuova Zelanda 5
CO - Colombia 4
IR - Iran 4
PT - Portogallo 4
AL - Albania 2
AU - Australia 2
BR - Brasile 2
CY - Cipro 2
CZ - Repubblica Ceca 2
EE - Estonia 2
LU - Lussemburgo 2
SK - Slovacchia (Repubblica Slovacca) 2
TW - Taiwan 2
AE - Emirati Arabi Uniti 1
AM - Armenia 1
CL - Cile 1
DZ - Algeria 1
EG - Egitto 1
ET - Etiopia 1
IL - Israele 1
LT - Lituania 1
MA - Marocco 1
MY - Malesia 1
NO - Norvegia 1
PE - Perù 1
PH - Filippine 1
TH - Thailandia 1
VN - Vietnam 1
Totale 9.074
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Città #
Fairfield 690
Rome 590
Chandler 466
Ottawa 414
Ashburn 389
Woodbridge 314
Houston 276
Seattle 250
Ann Arbor 238
Dearborn 226
Cambridge 216
Singapore 208
Wilmington 192
Princeton 130
San Jose 120
Santa Clara 94
Plano 84
Beijing 83
San Paolo di Civitate 70
Helsinki 67
Lawrence 67
Milan 61
Fasano 59
Boston 57
Millbury 53
Las Vegas 48
New York 47
San Diego 47
Belize City 42
Buffalo 42
Falls Church 38
Sofia 38
Jacksonville 35
Andover 34
Shanghai 32
Jakarta 31
Brussels 30
Washington 29
Dublin 27
Boardman 26
Los Angeles 26
Lomé 25
Norwalk 25
Bremen 24
Federal 23
Saint Louis 23
Toronto 23
Fremont 22
Grafing 22
Des Moines 21
Redwood City 21
Istanbul 20
Naples 19
Chicago 17
Mannheim 17
Greater Noida 16
Parma 16
Albuquerque 15
London 15
Florence 14
Moscow 14
Falkenstein 13
Hefei 11
Hong Kong 11
Nanjing 11
Bühl 10
Kunming 9
Phoenix 9
Columbus 8
Lappeenranta 8
Surabaya 8
Weston-super-Mare 8
Catania 7
Dallas 7
Edinburgh 7
Ferentino 7
Jinan 7
Paris 7
Trieste 7
Cagliari 6
Muizenberg 6
Palermo 6
Palo Alto 6
Perugia 6
San Mateo 6
Stockholm 6
Tokyo 6
Turin 6
Auckland 5
Berlin 5
Central 5
Decatur 5
Edmonton 5
Geneva 5
Lucknow 5
Moncalieri 5
Rieti 5
Zurich 5
Barcelona 4
Bari 4
Totale 6.645
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Nome #
PLP-dependent Enzymes: a Powerful Tool for Metabolic Synthesis of Non-canonical Amino Acids 344
Metodologie biochimiche. Espressione, purificazione e caratterizzazione delle proteine. Con espansione online 228
The expression of four pyridoxal kinase (pdxk) human variants in drosophila impacts on genome integrity 156
The moonlighting RNA-binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism 149
Differential 3-bromopyruvate inhibition of cytosolic and mitochondrial human serine hydroxymethyltransferase isoforms, key enzymes in cancer metabolic reprogramming 136
Human cytosolic and mitochondrial serine hydroxymethyltransferase isoforms in comparison: full kinetic characterization and substrate inhibition properties 134
Molecular basis of reduced pyridoxine 5'-phosphate oxidase catalytic activity in neonatal epileptic encephalopathy disorder. 129
Molecular mechanism of pdxr - a transcriptional activator involved in the regulation of vitamin b biosynthesis in the probiotic bacterium Bacillus clausii 127
Data from computational analysis of the peptide linkers in the mocr bacterial transcriptional regulators 124
Molecular mechanisms of the non-coenzyme action of thiamin in brain. Biochemical, structural and pathway analysis 122
The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells 119
A bioinformatics analysis reveals a group of MocR bacterial transcriptional regulators linked to a family of genes coding for membrane proteins 119
Screening and in vitro testing of antifolate inhibitors of human cytosolic serine hydroxymethyltransferase 118
Pyridoxine-5'-phosphate oxidase (pnpo) deficiency. clinical and biochemical alterations associated with the c.347g>a (pp. arg116gln) mutation 116
Threonine aldolase and alanine racemase: novel examples of convergent evolution in the superfamily of vitamin B6-dependent enzymes 115
Biochemical data from the characterization of a new pathogenic mutation of human pyridoxine-5'-phosphate oxidase (PNPO) 115
A comprehensive computational analysis of Mycobacterium genomes pinpoints the genes co-occurring with ycze, a membrane protein coding gene under the putative control of a mocr, and predicts its function 115
Isolation of a complex formed between acinetobacter baumannii hema and heml, key enzymes of tetrapyrroles biosynthesis 112
Pyridoxal 5’-Phosphate-Dependent Enzymes: Catalysis, Conformation and Genomics 110
Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex 109
Allosteric feedback inhibition of pyridoxine 5'-phosphate oxidase from escherichia coli 108
Pyridoxal 5’-Phosphate Enzymes as Targets for Therapeutic Agents. 107
How pyridoxal 5'-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state 106
Functional inactivation of drosophila GCK orthologs causes genomic instability and oxidative stress in a fly model of MODY-2 105
Biomedical aspects of pyridoxal 5’-phosphate availability 104
Asymmetry of the Active Site Loop Conformation between Subunits of Glutamate-1-semialdehyde Aminomutase in Solution 102
Study of DNA binding and bending by Bacillus subtilis GabR, a PLP-dependent transcription factor 102
Riboregulation as a new player in the control of cellular metabolism: clues from the cryo-EM structure of serine hydroxymethyltransferase-RNA complex 101
VITAMIN B(6) SALVAGE ENZYMES: MECHANISM, STRUCTURE AND REGULATION. 101
Pyridoxal 5’-Phosphate is a Slow Tight Binding Inhibitor of E. coli Pyridoxal Kinase 97
Glycine consumption and mitochondrial serine hydroxymethyltransferase in cancer cells: the heme connection 97
Molecular basis of E. coli l-threonine aldolase catalytic inactivation at low pH 95
Salmonella typhimurium PtsJ is a novel MocR-like transcriptional repressor involved in regulating the vitamin B6 salvage pathway 94
The MocR-like transcription factors: pyridoxal 5'-phosphate-dependent regulators of bacterial metabolism 93
Structural properties of the linkers connecting the n- and c- terminal domains in the mocr bacterial transcriptional regulators 89
Corrigendum to “Pyridoxine-5′-phosphate oxidase (Pnpo) deficiency: Clinical and biochemical alterations associated with the C.347g > A (P.·Arg116gln) mutation” [Mol. Genet. Metab. 122/1–2 (2017) 135–142] 89
Knowns and unknowns of vitamin B6 metabolism in escherichia coli 89
Identification of the pyridoxal 5′‐phosphate allosteric site in human pyridox(am)ine 5′‐phosphate oxidase 88
Alanine racemase from Tolypocladium inflatum: A key PLP-dependent enzyme in cyclosporin biosynthesis and a model of catalytic promiscuity 87
Role of a conserved active site cation-pi interaction in Escherichia coli serine hydroxymethyltransferase. 87
Differential inhibitory effect of a pyrazolopyran compound on human serine hydroxymethyltransferase-amino acid complexes 86
Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex 86
Identification and characterization of the pyridoxal 5'-phosphate allosteric site in Escherichia coli pyridoxine 5'-phosphate oxidase 85
Structural stability of cold-adapted serine hydroxymethyltransferase, a tool for ß-hydroxy-α-amino acid biosynthesis 85
Structural stability of the cofactor binding site in Escherichia coli serine hydroxymethyltransferase--the role of evolutionarily conserved hydrophobic contacts. 84
In silico and in vitro validation of serine hydroxymethyltransferase as a chemotherapeutic target of the antifolate drug pemetrexed 84
SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation 84
The mechanism of high-yielding chiral syntheses catalysed by wild-type and mutant forms of aspartate aminotransferase 84
The multifaceted role of vitamin b6 in cancer: drosophila as a model system to investigate dna damage 83
The crystal structure of archaeal serine hydroxymethyltransferase reveals idiosyncratic features likely required to withstand high temperatures 82
The aspartate aminotransferase-like domain of Firmicutes mocr transcriptional regulators 81
Structural and kinetic properties of serine hydroxymethyltransferase from the halophytic cyanobacterium aphanothece halophytica provide a rationale for salt tolerance 80
An engineered escherichia coli strain with synthetic metabolism for in‐cell production of translationally active methionine derivatives 79
Stereochemistry of the reactions of glutamate-1-semialdehyde aminomutase with 4,5-diaminovalerate 79
On the mechanism of Escherichia coli pyridoxal kinase inhibition by pyridoxal and pyridoxal 5'-phosphate 79
Vitamin B6 rescues insulin resistance and glucose-induced DNA damage caused by reduced activity of Drosophila PI3K 79
Molecular Defects of Vitamin B6 Metabolism Associated with Neonatal Epileptic Encephalopathy 78
A pyrazolopyran derivative preferentially inhibits the activity of human cytosolic hydroxymethyltransferase and induces cell death in lung cancer cells 78
The contribution of a conformationally-mobile, active-site loop to the reaction catalysed by glutamate semialdehyde aminomutase 77
Mutation of tyrosine 332 to phenylalanine converts dopa decarboxylase into a decarboxylation-dependent oxidative deaminase 77
Metodologie Biochimiche 76
Inhibition of human pyridoxal kinase by 2-acetyl-4-((1R,2S,3R)-1,2,3,4-1 tetrahydroxybutyl)-imidazole (THI) 76
Interaction of Bacillus subtilis GabR with the gabTD promoter: role of repeated sequences and effect of GABA in transcriptional activation 75
L-Threonine aldolase, serine hydroxymethyltransferase and fungal alanine racemase. A subsgroup of strictly related enzymes specialized for different functions 74
Editorial: PLP-dependent enzymes: extraordinary versatile catalysts and ideal biotechnological tools for the production of unnatural amino acids and related compounds 74
Structure-based mechanism of riboregulation of the metabolic enzyme SHMT1 73
Coupling bioorthogonal chemistries with artificial metabolism: Intracellular biosynthesis of azidohomoalanine and its incorporation into recombinant proteins 73
Crystal Structures of Human Pyridoxal Kinase in Complex with the Neurotoxins, Ginkgotoxin and Theophylline: Insights into Pyridoxal Kinase Inhibition 73
Molecular characterization of pyridoxine 5′-phosphate oxidase and its pathogenic forms associated with neonatal epileptic encephalopathy 73
Role of Y65 and E57 in Escherichia coli serine hydroxymethyltransferase 72
The role of evolutionarily conserved hydrophobic contacts in the quaternary structure stability of Escherichia coli serine hydroxymethyltransferase 72
Structural basis of methotrexate and pemetrexed action on serine hydroxymethyltransferases revealed using plant models 72
Structure-Based Mechanism for Early PLP-Mediated Steps of Rabbit Cytosolic Serine Hydroxymethyltransferase Reaction 72
Reactions of glutamate semialdehyde aminotransferase (glutamate-1-semialdehyde 2,1 aminomutase) with vinyl and acetylenic substrate analogues analysed by rapid scanning spectrophotometry. 71
Serine hydroxymethyltransferase: A model enzyme for mechanistic, structural, and evolutionary studies. 69
Metodologie biochimiche. Principi e tecniche per l'espressione, la purificazione e la caratterizzazione delle proteine 69
The reactions of glutamate semialdehyde aminomutase with (R) and (S)-enantiomers of a novel, mechanism-based inhibitor, 2, 3-diaminopropyl sulfate 68
THE CONTRIBUTION OF A CONFORMATIONALLY MOBILE ACTIVE SITE LOOP TO THE REACTION CATALYZED BY GLUTAMATE SEMIALDEYDE AMINOMUTASE 67
Serine hydroxymethyltransferase: role of the active site lysine in the mechanism of the enzyme. 66
“L-Threonine aldolase, serine hydroxymethyltransferase and fungal alanine racemase. A subgroup of strictly related enzymes specialized for different functions”, in the 3rd International Symposium on Vitamin B6, PQQ, Carbonyl Catalysis and Quinoproteins, Southampton, United Kingdom, 14-19 April 2002. 66
On the catalytic mechanism and stereospecificity of Escherichia coli L-threonine aldolase 64
A gene-nutrient interaction between vitamin B6 and serine hydroxymethyltransferase (SHMT) affects genome integrity in Drosophila 62
The Structure of Serine Hydroxymethyltransferase as modelled by Homology and validated by Site Directed Mutagenesis 61
A novel, easy assay method for human cysteine sulfinic acid decarboxylase 59
null 57
Enzymatic synthesis of omega-carboxy-beta-hydroxy-(L)-alpha-amino acids 56
Thiamine-dependent regulation of mammalian brain pyridoxal kinase in vitro and in vivo 56
COMUNICAZIONE ORALE A CONGRESSO SU INVITO “On the mechanism of addition of pyridoxal 5’-phosphate to serine hydroxymethyltransferase”, in The Third International Conference on Cofactors (ICC03), Finland, Turku, 10-15 July 2011. 55
Crystal structure of glutamate-1-semialdehyde. An alpha-2-dimeric vitamin B6 dependent enzyme with asymmetry in structure and active site reactivity 54
PLP-dependent enzymes. 53
COMUNICAZIONE ORALE A CONGRESSO SU INVITO “Studies on the evolutionary origins of pyridoxal-phosphate-dependent enzymes: catalytic promiscuity and reaction specificity”, in “Quo Vadis Proteomics”, Napoli, 26 Marzo 2001. 53
Metodologie biochimiche. Principi e tecniche per l'espressione, la purificazione e la caratterizzazione delle proteine 52
Pha-680626 is an effective inhibitor of the interaction between aurora-a and n-myc 51
BIOCHIMICA per Studenti di Scienze della Vita 49
Catalytic and thermodynamic properties of tetrahydromethanopterin-dependent serine hydroxymethyltransferase from Methanococcus jannaschii. 49
Isoforms of the DHTKD1-encoded 2-oxoadipate dehydrogenase, identified in animal tissues, are not observed upon the human DHTKD1 expression in bacterial or yeast systems 48
Metformin is a pyridoxal-5′-phosphate (PLP)-competitive inhibitor of SHMT2 48
Reactions of glutamate 1-semialdehyde aminomutase with R- and S-enantiomers of a novel, mechanism-based inhibitor, 2,3-diaminopropyl sulphate 45
The structure of serine hydrxymethyltransferase as modeled by homology and validated by site-directed mutagenesis 45
THE STRUCTURE OF SERINE HYDROXYMETHYLTRANSFERASE MODELLED BY HOMOLOGY AND VALIDATED BY SITE DIRECTED MUTAGENESIS 45
Totale 8.861
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Categoria #
all - tutte 27.716
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 585
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 28.301
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.049 0 0 0 0 0 277 224 156 145 95 95 57
2020/20211.051 66 51 29 206 81 53 8 86 124 193 115 39
2021/20221.985 53 203 133 52 241 80 75 405 171 98 235 239
2022/20231.604 231 257 77 276 198 160 24 97 133 29 74 48
2023/20241.390 63 107 134 260 116 184 55 142 22 129 87 91
2024/2025801 141 47 107 167 176 163 0 0 0 0 0 0
Totale 9.530