A perturbed uptake of micronutrients, such as minerals and vitamins, impacts on different human diseases, including cancer and neurological disorders. Several data converge towards a crucial role played by many micronutrients in genome integrity maintenance and in the establishment of a correct DNA methylation pattern. Failure in the proper accomplishment of these processes accelerates senescence and increases the risk of developing cancer, by promoting the formation of chromosome aberrations and deregulating the expression of oncogenes. Here, the main recent evidence regarding the impact of some B vitamins on DNA damage and cancer is summarized, providing an integrated and updated analysis, mainly centred on vitamin B6. In many cases, it is difficult to finely predict the optimal vitamin rate that is able to protect against DNA damage, as this can be influenced by a given individual's genotype. For this purpose, a precious resort is represented by model organisms which allow limitations imposed by more complex systems to be overcome. In this review, we show that Drosophila can be a useful model to deeply understand mechanisms underlying the relationship between vitamin B6 and genome integrity.

The multifaceted role of vitamin b6 in cancer: drosophila as a model system to investigate dna damage / Contestabile, R.; di Salvo, M. L.; Bunik, V.; Tramonti, A.; Verni, F.. - In: OPEN BIOLOGY. - ISSN 2046-2441. - 10:3(2020), p. 200034. [10.1098/rsob.200034]

The multifaceted role of vitamin b6 in cancer: drosophila as a model system to investigate dna damage

Contestabile R.;di Salvo M. L.;Tramonti A.
;
Verni F.
2020

Abstract

A perturbed uptake of micronutrients, such as minerals and vitamins, impacts on different human diseases, including cancer and neurological disorders. Several data converge towards a crucial role played by many micronutrients in genome integrity maintenance and in the establishment of a correct DNA methylation pattern. Failure in the proper accomplishment of these processes accelerates senescence and increases the risk of developing cancer, by promoting the formation of chromosome aberrations and deregulating the expression of oncogenes. Here, the main recent evidence regarding the impact of some B vitamins on DNA damage and cancer is summarized, providing an integrated and updated analysis, mainly centred on vitamin B6. In many cases, it is difficult to finely predict the optimal vitamin rate that is able to protect against DNA damage, as this can be influenced by a given individual's genotype. For this purpose, a precious resort is represented by model organisms which allow limitations imposed by more complex systems to be overcome. In this review, we show that Drosophila can be a useful model to deeply understand mechanisms underlying the relationship between vitamin B6 and genome integrity.
2020
cancer; drosophila melanogaster; genome integrity; vitamin b 6
01 Pubblicazione su rivista::01a Articolo in rivista
The multifaceted role of vitamin b6 in cancer: drosophila as a model system to investigate dna damage / Contestabile, R.; di Salvo, M. L.; Bunik, V.; Tramonti, A.; Verni, F.. - In: OPEN BIOLOGY. - ISSN 2046-2441. - 10:3(2020), p. 200034. [10.1098/rsob.200034]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1396007
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