CONTESTABILE, Roberto
 Distribuzione geografica
Continente #
NA - Nord America 988
EU - Europa 591
AS - Asia 98
SA - Sud America 14
AF - Africa 10
Continente sconosciuto - Info sul continente non disponibili 1
OC - Oceania 1
Totale 1.703
Nazione #
US - Stati Uniti d'America 971
IT - Italia 323
FR - Francia 94
DE - Germania 43
CN - Cina 41
NL - Olanda 32
FI - Finlandia 14
UA - Ucraina 12
CA - Canada 11
JP - Giappone 11
RU - Federazione Russa 11
ES - Italia 9
HK - Hong Kong 8
ZA - Sudafrica 8
AL - Albania 6
BG - Bulgaria 6
CL - Cile 6
CZ - Repubblica Ceca 6
IN - India 6
BE - Belgio 5
CH - Svizzera 5
GB - Regno Unito 5
MX - Messico 5
AE - Emirati Arabi Uniti 4
BR - Brasile 4
EC - Ecuador 4
SA - Arabia Saudita 4
IE - Irlanda 3
IR - Iran 3
LT - Lituania 3
MY - Malesia 3
PH - Filippine 3
RO - Romania 3
SE - Svezia 3
TR - Turchia 3
AT - Austria 2
HU - Ungheria 2
ID - Indonesia 2
IQ - Iraq 2
JO - Giordania 2
LV - Lettonia 2
SG - Singapore 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AU - Australia 1
EE - Estonia 1
EG - Egitto 1
GE - Georgia 1
GR - Grecia 1
HN - Honduras 1
KR - Corea 1
NG - Nigeria 1
PK - Pakistan 1
TW - Taiwan 1
Totale 1.703
Città #
Rome 186
Santa Cruz 112
Fairfield 95
Ashburn 70
Seattle 63
Buffalo 57
Houston 50
Woodbridge 46
Cambridge 36
Columbus 27
Wilmington 20
Chicago 17
Des Moines 17
Los Angeles 17
Meppel 15
Paris 13
Ann Arbor 10
Helsinki 10
Jinan 10
San Diego 10
Boardman 8
Clearwater 8
Council Bluffs 8
Muizenberg 8
Las Vegas 7
Milan 7
Mountain View 6
Sofia 6
Andover 5
Atlanta 5
Ottawa 5
San Francisco 5
San Jose 5
Beijing 4
Crugers 4
Dallas 4
Henderson 4
Lappeenranta 4
Miami 4
Phoenix 4
Provo 4
Rieti 4
Riva 4
Yokohama 4
Bitonto 3
Brussels 3
Cedar Knolls 3
Kuala Lumpur 3
Munich 3
Naples 3
New York 3
Pasadena 3
Riyadh 3
Shanghai 3
Toronto 3
Amman 2
Amsterdam 2
Ankara 2
Aprilia 2
Ascoli Piceno 2
Ashville 2
Baghdad 2
Bremen 2
Carlsbad 2
Chandler 2
Chilpancingo 2
Denver 2
Domnesti 2
Dublin 2
Düsseldorf 2
Florence 2
Fondi 2
Frankfurt am Main 2
Geneva 2
Guangzhou 2
Guanujo 2
Hanover 2
Hyderabad 2
Jacksonville 2
Jakarta 2
Jersey City 2
Kizugawa-shi 2
Krasnoobsk 2
Kyoto 2
Lake Forest 2
Lanciano 2
Langen 2
Lessolo 2
Leuven 2
Lincoln 2
Lincolnshire 2
Llagostera 2
Lombard 2
Modena 2
Nanjing 2
Napoli 2
North 2
Offlaga 2
Philadelphia 2
Pomezia 2
Totale 1.131
Nome #
Biochemical data from the characterization of a new pathogenic mutation of human pyridoxine-5'-phosphate oxidase (PNPO), file e3835318-3348-15e8-e053-a505fe0a3de9 130
Data from computational analysis of the peptide linkers in the mocr bacterial transcriptional regulators, file e383531d-3015-15e8-e053-a505fe0a3de9 123
Molecular mechanisms of the non-coenzyme action of thiamin in brain. Biochemical, structural and pathway analysis, file e3835312-97d7-15e8-e053-a505fe0a3de9 103
An engineered escherichia coli strain with synthetic metabolism for in‐cell production of translationally active methionine derivatives, file e3835328-4242-15e8-e053-a505fe0a3de9 97
The expression of four pyridoxal kinase (pdxk) human variants in drosophila impacts on genome integrity, file e3835323-a3af-15e8-e053-a505fe0a3de9 95
Structural basis of methotrexate and pemetrexed action on serine hydroxymethyltransferases revealed using plant models, file e3835324-989a-15e8-e053-a505fe0a3de9 90
The multifaceted role of vitamin b6 in cancer: drosophila as a model system to investigate dna damage, file e3835325-cb7a-15e8-e053-a505fe0a3de9 87
Structural properties of the linkers connecting the n- and c- terminal domains in the mocr bacterial transcriptional regulators, file e3835315-2505-15e8-e053-a505fe0a3de9 81
Isolation of a complex formed between acinetobacter baumannii hema and heml, key enzymes of tetrapyrroles biosynthesis, file e3835321-ba1f-15e8-e053-a505fe0a3de9 79
Vitamin B6 rescues insulin resistance and glucose-induced DNA damage caused by reduced activity of Drosophila PI3K, file e383532f-1095-15e8-e053-a505fe0a3de9 79
Metformin is a pyridoxal-5′-phosphate (PLP)-competitive inhibitor of SHMT2, file e383532c-ff14-15e8-e053-a505fe0a3de9 73
Editorial: PLP-dependent enzymes: extraordinary versatile catalysts and ideal biotechnological tools for the production of unnatural amino acids and related compounds, file e3835325-05b4-15e8-e053-a505fe0a3de9 72
Identification and characterization of the pyridoxal 5'-phosphate allosteric site in Escherichia coli pyridoxine 5'-phosphate oxidase, file e383532c-8b6d-15e8-e053-a505fe0a3de9 63
Molecular characterization of pyridoxine 5′-phosphate oxidase and its pathogenic forms associated with neonatal epileptic encephalopathy, file e3835327-f4ee-15e8-e053-a505fe0a3de9 62
The moonlighting RNA-binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism, file e383532b-a912-15e8-e053-a505fe0a3de9 59
Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex, file 51190e37-1bfb-4182-b45b-9b929b4c9631 51
A gene-nutrient interaction between vitamin B6 and serine hydroxymethyltransferase (SHMT) affects genome integrity in Drosophila, file 5d24f53c-f188-4678-9626-2cc1e0da874d 50
A pyrazolopyran derivative preferentially inhibits the activity of human cytosolic hydroxymethyltransferase and induces cell death in lung cancer cells, file e383531b-95a6-15e8-e053-a505fe0a3de9 47
A novel, easy assay method for human cysteine sulfinic acid decarboxylase, file e383532c-975d-15e8-e053-a505fe0a3de9 39
Arabidopsis thaliana serine hydroxymethyltransferases: functions, structures, and perspectives, file 83bc233e-ae43-497f-be8c-d02a85191a61 36
Glycine consumption and mitochondrial serine hydroxymethyltransferase in cancer cells: the heme connection, file e3835312-41b7-15e8-e053-a505fe0a3de9 24
Characterization of novel pathogenic variants causing pyridox(Am)ine 5′-phosphate oxidase-dependent epilepsy, file e383532d-880f-15e8-e053-a505fe0a3de9 22
Functional and structural properties of pyridoxal reductase (PdxI) from Escherichia coli. A pivotal enzyme in the vitamin B6 salvage pathway, file 6c318278-1083-4be3-8484-66ccc848dc5f 15
In silico and in vitro validation of serine hydroxymethyltransferase as a chemotherapeutic target of the antifolate drug pemetrexed, file e3835312-1bd2-15e8-e053-a505fe0a3de9 14
Pha-680626 is an effective inhibitor of the interaction between aurora-a and n-myc, file e383532e-100b-15e8-e053-a505fe0a3de9 14
Characterization of the Escherichia coli pyridoxal 5'-phosphate homeostasis protein (YggS): Role of lysine residues in PLP binding and protein stability, file bcfdd474-576d-4e06-b2b1-110953d28662 13
Structural insights into the DNA recognition mechanism by the bacterial transcription factor PdxR, file c3700b44-1be9-4e97-b61a-33c0c966edc0 12
4'-Deoxypyridoxine disrupts vitamin B6 homeostasis in Escherichia coli K12 through combined inhibition of cumulative B6 uptake and PLP-dependent enzyme activity, file 16fde3d4-2e02-490b-b92c-b4e2e92182ee 10
The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells, file e383531b-a557-15e8-e053-a505fe0a3de9 8
Identification of the pyridoxal 5′‐phosphate allosteric site in human pyridox(am)ine 5′‐phosphate oxidase, file 662ddbec-f623-4b1b-b641-f9dd6fbbfd02 6
PLP-dependent Enzymes: a Powerful Tool for Metabolic Synthesis of Non-canonical Amino Acids, file e3835312-b4df-15e8-e053-a505fe0a3de9 5
Salmonella typhimurium PtsJ is a novel MocR-like transcriptional repressor involved in regulating the vitamin B6 salvage pathway, file e3835316-b4ed-15e8-e053-a505fe0a3de9 5
The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells, file e383531b-a559-15e8-e053-a505fe0a3de9 5
The MocR-like transcription factors: pyridoxal 5'-phosphate-dependent regulators of bacterial metabolism, file e383531d-2e5b-15e8-e053-a505fe0a3de9 5
Thiamine-dependent regulation of mammalian brain pyridoxal kinase in vitro and in vivo, file e383532e-1290-15e8-e053-a505fe0a3de9 5
Insights into the substrate specificity, structure, and dynamics of plant histidinol-phosphate aminotransferase (HISN6), file 0dd8d068-c2db-4577-bd88-127dc361cd1e 4
Structural insights into the DNA recognition mechanism by the bacterial transcription factor PdxR, file 490739ea-4da7-4d73-b2a5-cf63765b6fd2 4
Coupling bioorthogonal chemistries with artificial metabolism: Intracellular biosynthesis of azidohomoalanine and its incorporation into recombinant proteins, file e3835311-d399-15e8-e053-a505fe0a3de9 4
Molecular mechanism of pdxr - a transcriptional activator involved in the regulation of vitamin b biosynthesis in the probiotic bacterium Bacillus clausii, file e3835312-ad18-15e8-e053-a505fe0a3de9 4
Differential 3-bromopyruvate inhibition of cytosolic and mitochondrial human serine hydroxymethyltransferase isoforms, key enzymes in cancer metabolic reprogramming, file e3835315-9ad1-15e8-e053-a505fe0a3de9 4
Study of DNA binding and bending by Bacillus subtilis GabR, a PLP-dependent transcription factor, file e3835316-ac56-15e8-e053-a505fe0a3de9 4
PLP-dependent enzymes., file e3835312-6275-15e8-e053-a505fe0a3de9 3
SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation, file e3835313-2a61-15e8-e053-a505fe0a3de9 3
Differential inhibitory effect of a pyrazolopyran compound on human serine hydroxymethyltransferase-amino acid complexes, file e383531b-4719-15e8-e053-a505fe0a3de9 3
Structural and kinetic properties of serine hydroxymethyltransferase from the halophytic cyanobacterium aphanothece halophytica provide a rationale for salt tolerance, file e3835326-c21a-15e8-e053-a505fe0a3de9 3
Isoforms of the DHTKD1-encoded 2-oxoadipate dehydrogenase, identified in animal tissues, are not observed upon the human DHTKD1 expression in bacterial or yeast systems, file e3835328-0744-15e8-e053-a505fe0a3de9 3
Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex, file e383532c-79c1-15e8-e053-a505fe0a3de9 3
Functional inactivation of drosophila GCK orthologs causes genomic instability and oxidative stress in a fly model of MODY-2, file ab4c13d9-f05c-4db6-bac4-e687dc1d125c 2
L-Threonine aldolase, serine hydroxymethyltransferase and fungal alanine racemase. A subsgroup of strictly related enzymes specialized for different functions, file e3835311-83ab-15e8-e053-a505fe0a3de9 2
On the mechanism of Escherichia coli pyridoxal kinase inhibition by pyridoxal and pyridoxal 5'-phosphate, file e3835312-376f-15e8-e053-a505fe0a3de9 2
Inhibition of human pyridoxal kinase by 2-acetyl-4-((1R,2S,3R)-1,2,3,4-1 tetrahydroxybutyl)-imidazole (THI), file e3835312-700b-15e8-e053-a505fe0a3de9 2
Structural stability of cold-adapted serine hydroxymethyltransferase, a tool for ß-hydroxy-α-amino acid biosynthesis, file e3835312-c152-15e8-e053-a505fe0a3de9 2
Human cytosolic and mitochondrial serine hydroxymethyltransferase isoforms in comparison: full kinetic characterization and substrate inhibition properties, file e383531f-b29b-15e8-e053-a505fe0a3de9 2
L-threonine aldolase, serine hydroxymethyltransferase and fungal alanine racemase: structural diversity and uniformity in a subgroup of closely related enzymes catalysing different reactions, file e3835322-af5c-15e8-e053-a505fe0a3de9 2
Interaction of Bacillus subtilis GabR with the gabTD promoter: role of repeated sequences and effect of GABA in transcriptional activation, file e3835325-eaaa-15e8-e053-a505fe0a3de9 2
Allosteric feedback inhibition of pyridoxine 5'-phosphate oxidase from escherichia coli, file e3835326-9f21-15e8-e053-a505fe0a3de9 2
Knowns and unknowns of vitamin B6 metabolism in escherichia coli, file e383532c-2532-15e8-e053-a505fe0a3de9 2
Riboregulation as a new player in the control of cellular metabolism: clues from the cryo-EM structure of serine hydroxymethyltransferase-RNA complex, file e7119907-61fa-4734-9b61-3a8a6b9ba9c1 2
Enzymatic synthesis of omega-carboxy-beta-hydroxy-(L)-alpha-amino acids, file e3835311-50ce-15e8-e053-a505fe0a3de9 1
Pyridoxal 5’-Phosphate Enzymes as Targets for Therapeutic Agents., file e3835311-698e-15e8-e053-a505fe0a3de9 1
Biomedical aspects of pyridoxal 5’-phosphate availability, file e3835311-6b1e-15e8-e053-a505fe0a3de9 1
THE CONTRIBUTION OF A CONFORMATIONALLY MOBILE ACTIVE SITE LOOP TO THE REACTION CATALYZED BY GLUTAMATE SEMIALDEYDE AMINOMUTASE, file e3835311-85c0-15e8-e053-a505fe0a3de9 1
Catalytic and thermodynamic properties of tetrahydromethanopterin-dependent serine hydroxymethyltransferase from Methanococcus jannaschii., file e3835311-8e98-15e8-e053-a505fe0a3de9 1
Role of Tyrosine 65 in the mechanism of serine hydroxymethyltrasferase, file e3835311-a856-15e8-e053-a505fe0a3de9 1
The reactions of glutamate semialdehyde aminomutase with (R) and (S)-enantiomers of a novel, mechanism-based inhibitor, 2, 3-diaminopropyl sulfate, file e3835311-afc3-15e8-e053-a505fe0a3de9 1
Crystal structure of glutamate-1-semialdehyde. An alpha-2-dimeric vitamin B6 dependent enzyme with asymmetry in structure and active site reactivity, file e3835311-afc4-15e8-e053-a505fe0a3de9 1
The mechanism of high-yielding chiral syntheses catalysed by wild-type and mutant forms of aspartate aminotransferase, file e3835311-afc5-15e8-e053-a505fe0a3de9 1
Reactions of glutamate semialdehyde aminotransferase (glutamate-1-semialdehyde 2,1 aminomutase) with vinyl and acetylenic substrate analogues analysed by rapid scanning spectrophotometry., file e3835311-afc6-15e8-e053-a505fe0a3de9 1
Mutation of tyrosine 332 to phenylalanine converts dopa decarboxylase into a decarboxylation-dependent oxidative deaminase, file e3835311-afc8-15e8-e053-a505fe0a3de9 1
Molecular basis of E. coli l-threonine aldolase catalytic inactivation at low pH, file e3835311-e9be-15e8-e053-a505fe0a3de9 1
Corrigendum to “Pyridoxine-5′-phosphate oxidase (Pnpo) deficiency: Clinical and biochemical alterations associated with the C.347g > A (P.·Arg116gln) mutation” [Mol. Genet. Metab. 122/1–2 (2017) 135–142], file e3835319-f540-15e8-e053-a505fe0a3de9 1
The aspartate aminotransferase-like domain of Firmicutes mocr transcriptional regulators, file e383531d-5a56-15e8-e053-a505fe0a3de9 1
Pyridoxine-5'-phosphate oxidase (pnpo) deficiency. clinical and biochemical alterations associated with the c.347g>a (pp. arg116gln) mutation, file e383532b-6ec1-15e8-e053-a505fe0a3de9 1
Totale 1.758
Categoria #
all - tutte 4.560
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 4.560


Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/201963 0 0 0 0 0 0 0 0 0 0 29 34
2019/2020184 15 11 5 6 11 11 28 23 27 19 9 19
2020/2021275 19 16 6 15 41 24 8 21 25 48 36 16
2021/2022350 32 26 26 13 27 22 11 19 14 14 102 44
2022/2023435 16 13 104 78 29 43 46 27 19 14 26 20
2023/2024384 21 17 26 32 65 32 51 44 11 26 59 0
Totale 1.758