Pyridoxal 59-phosphate (PLP)-dependent enzymes represent about 4% of the enzymes classified by the Enzyme Commission. The versatility of PLP in carrying out a large variety of reactions exploiting the electron sink effect of the pyridine ring, the conformational changes accompanying the chemical steps and stabilizing distinct catalytic intermediates, and the spectral properties of the different coenzyme–substrate derivatives signaling the reaction progress are some of the key features of PLP and PLP-dependent catalytic action. Progress in PLP-dependent enzymes functional genomics and development of inhibitors with therapeutic activity highlight the continuous novelty of an ‘old’ class of enzymes.

Pyridoxal 5’-Phosphate-Dependent Enzymes: Catalysis, Conformation and Genomics / Raboni, S; Contestabile, Roberto; Spyrakis, F; Campanini, B; Amadasi, A; Bettati, S; Peracchi, A. AND MOZZARELLI A.. - STAMPA. - 7(2010), pp. 273-350.

Pyridoxal 5’-Phosphate-Dependent Enzymes: Catalysis, Conformation and Genomics

CONTESTABILE, Roberto;
2010

Abstract

Pyridoxal 59-phosphate (PLP)-dependent enzymes represent about 4% of the enzymes classified by the Enzyme Commission. The versatility of PLP in carrying out a large variety of reactions exploiting the electron sink effect of the pyridine ring, the conformational changes accompanying the chemical steps and stabilizing distinct catalytic intermediates, and the spectral properties of the different coenzyme–substrate derivatives signaling the reaction progress are some of the key features of PLP and PLP-dependent catalytic action. Progress in PLP-dependent enzymes functional genomics and development of inhibitors with therapeutic activity highlight the continuous novelty of an ‘old’ class of enzymes.
2010
COMPREHENSIVE NATURAL PRODUCTS IIChemistry and Biology
9780080453811
02 Pubblicazione su volume::02a Capitolo o Articolo
Pyridoxal 5’-Phosphate-Dependent Enzymes: Catalysis, Conformation and Genomics / Raboni, S; Contestabile, Roberto; Spyrakis, F; Campanini, B; Amadasi, A; Bettati, S; Peracchi, A. AND MOZZARELLI A.. - STAMPA. - 7(2010), pp. 273-350.
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/176971
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 21
  • ???jsp.display-item.citation.isi??? ND
social impact