Catalogo dei prodotti della ricerca

ROTILI, Dante
 Distribuzione geografica
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Continente #
NA - Nord America 6.827
EU - Europa 3.006
AS - Asia 1.242
SA - Sud America 59
AF - Africa 42
OC - Oceania 5
Continente sconosciuto - Info sul continente non disponibili 3
Totale 11.184
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Nazione #
US - Stati Uniti d'America 6.774
IT - Italia 1.538
SG - Singapore 488
SE - Svezia 379
IN - India 321
CN - Cina 305
FI - Finlandia 209
GB - Regno Unito 174
DE - Germania 140
UA - Ucraina 123
BG - Bulgaria 98
ID - Indonesia 55
BE - Belgio 49
FR - Francia 48
IE - Irlanda 47
CA - Canada 44
RO - Romania 43
NL - Olanda 38
AR - Argentina 36
ES - Italia 34
TG - Togo 30
RU - Federazione Russa 24
AT - Austria 21
HK - Hong Kong 21
BR - Brasile 18
CH - Svizzera 16
KR - Corea 14
IL - Israele 10
JP - Giappone 8
MX - Messico 8
ET - Etiopia 5
GR - Grecia 5
PL - Polonia 5
AU - Australia 4
DK - Danimarca 4
PK - Pakistan 4
EU - Europa 3
IR - Iran 3
NO - Norvegia 3
AM - Armenia 2
BD - Bangladesh 2
BY - Bielorussia 2
CO - Colombia 2
DZ - Algeria 2
AL - Albania 1
AZ - Azerbaigian 1
BJ - Benin 1
CG - Congo 1
CI - Costa d'Avorio 1
CL - Cile 1
CZ - Repubblica Ceca 1
EG - Egitto 1
HR - Croazia 1
JO - Giordania 1
KG - Kirghizistan 1
KH - Cambogia 1
LT - Lituania 1
LV - Lettonia 1
MY - Malesia 1
NZ - Nuova Zelanda 1
PA - Panama 1
PE - Perù 1
PH - Filippine 1
PT - Portogallo 1
SA - Arabia Saudita 1
TR - Turchia 1
TW - Taiwan 1
VE - Venezuela 1
ZA - Sudafrica 1
Totale 11.184
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Città #
Fairfield 1.171
Ashburn 667
Rome 659
Woodbridge 542
Houston 428
Seattle 419
Chandler 391
Singapore 361
Cambridge 347
Wilmington 336
Ann Arbor 190
Princeton 186
San Paolo di Civitate 171
Santa Clara 165
New York 153
Dearborn 135
Lawrence 128
Plano 109
Helsinki 99
Beijing 98
Sofia 97
San Diego 94
Millbury 89
Boston 78
Andover 56
Jakarta 54
Monte Cremasco 49
Des Moines 48
Dublin 44
Milan 44
Washington 35
Federal 34
Jacksonville 34
Lomé 30
Stockholm 28
Toronto 28
Boardman 26
Fasano 26
Florence 22
Barcelona 21
Naples 20
Norwalk 20
Los Angeles 19
Bühl 18
Vienna 18
Deurne 16
Hefei 16
Kunming 16
Lappeenranta 16
London 16
Nanjing 16
Bologna 15
Bremen 14
Brussels 14
Moscow 14
Leuven 13
Mannheim 13
Palermo 13
Phoenix 13
Caserta 12
Falkenstein 12
Falls Church 12
Ottawa 11
Pune 11
Shanghai 11
Dallas 10
Amsterdam 9
Guangzhou 9
Jinan 9
Paris 9
Latina 8
Turin 8
Frattamaggiore 7
Grafing 7
New Delhi 7
Perugia 7
Pessac 7
Philadelphia 7
Brescia 6
Fremont 6
Incheon 6
Leipzig 6
L’Aquila 6
Nanchang 6
Nuremberg 6
Paderno Dugnano 6
Padova 6
Sacramento 6
Sulmona 6
Treviso 6
Venezia 6
Aversa 5
Chengdu 5
Chicago 5
Chongqing 5
Frankfurt am Main 5
Laurel 5
Madrid 5
Mexico City 5
Mountain View 5
Totale 8.288
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Nome #
Hydrophilic gold nanoparticles as Anti-PD-L1 antibody carriers. Synthesis and interface properties 122
Mass spectrometry characterization of DOTA-Nimotuzumab conjugate as precursor of an innovative β − tracer suitable in radio-guided surgery 118
2-(Alkyl/aryl)amino-6-benzylpyrimidin-4(3H)-ones as inhibitors of wild-type and mutant HIV-1: enantioselectivity studies. 115
Disruptor of telomeric silencing 1-like (DOT1L): disclosing a new class of non-nucleoside inhibitors by means of ligand-based and structure-based approaches 114
SIRT5 regulation of ammonia-induced autophagy and mitophagy 114
Feasibility of beta-particle radioguided surgery for a variety of “nuclear medicine” radionuclides 111
Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma. 110
RIP1-HAT1-SirT complex identification and targeting in treatment and prevention of cancer 110
Identification of small molecules inhibitors of GCN5 histone acetyltransferase activity 109
Effect of α-methoxy substitution on the anti-HIV activity of dihydropyrimidin-4(3 H)-ones 107
Neuroprotective effects of PARP inhibitors in Drosophila models of Alzheimer’s disease 104
Y3+ embedded in polymeric nanoparticles: Morphology, dimension and stability of composite colloidal system 101
The histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces cardiac arrhythmias in dystrophic mice 100
Multimodal evaluation of 19F-BPA internalization in pancreatic cancer cells for boron capture and proton therapy potential applications 96
5-Alkyl-6-benzyl-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones, a series of anti-HIV-1 agents of the dihydro-alkoxy-benzyl-oxopyrimidine family with peculiar structure-activity relationship profile. 95
Novel pyrrole-containing histone deacetylase inhibitors endowed with cytodifferentiation activity 94
Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells 93
Gold nanoparticles and nanorods in nuclear medicine: a mini review 92
Biochemical functions and clinical characterizations of the sirtuins in diabetes-induced retinal pathologies 92
Exploring the role of 2-chloro-6-fluoro substitution in 2-alkylthio-6-benzyl-5-alkylpyrimidin-4(3H)-ones: effects in HIV-1-infected cells and in HIV-1 reverse transcriptase enzymes 91
Development of 1,2,4-oxadiazoles as potent and selective inhibitors of the human deacetylase sirtuin 2: structure-activity relationship, X-ray crystal structure, and anticancer activity 90
Chiral HPLC separation and absolute configuration of novel S-DABO derivatives. 90
Nitric oxide determines mesodermic differentiation of mouse embryonic stem cells by activating class IIa histone deacetylases: potential therapeutic implications in a mouse model of hindlimb ischemia 89
KAT3B-p300 and H3AcK18/H3AcK14 levels are prognostic markers for kidney ccRCC tumor aggressiveness and target of KAT inhibitor CPTH2 89
90Y-DOTA-nimotuzumab: synthesis of a promising β⁻ radiopharmaceutical 89
Pyrrole- and indole-containing tranylcypromine derivatives as novel lysine-specific demethylase 1 inhibitors active on cancer cells. 87
Histone acetyltransferase inhibitor CPTH6 preferentially targets lung cancer stem-like cells 87
Epigenetic polypharmacology: a new frontier for epi-drug discovery 86
Epigenetic modulators as a new strategies to reduce Aspergillus pathogenicity 86
Enhancing sensitivity of triple-negative breast cancer to DNA-damaging therapy through chemical inhibition of the m6A methyltransferase METTL3 85
Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities 85
Identification of novel quinazoline derivatives as potent antiplasmodial agents 85
Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features 85
Proteomic profile of differentially expressed plasma proteins from dystrophic mice and following suberoylanilide hydroxamic acid treatment 84
Characterization of Sirtuin Inhibitors in Nematodes Expressing a Muscular Dystrophy Protein Reveals Muscle Cell and Behavioral Protection by Specific Sirtinol Analogues 83
Carprofen Analogues as Sirtuin Inhibitors: Enzyme and Cellular Studies 83
Quinoline-based p300 histone acetyltransferase inhibitors with pro-apoptotic activity in human leukemia U937 cells. 83
Lysine acetyltransferase inhibitors: structure-activity relationships and potential therapeutic implications 82
Properly substituted analogues of BIX-01294 lose inhibition of G9a histone methyltransferase and gain selective anti-DNA methyltransferase 3A activity. 81
The relevance of Ki calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor. 80
Lysine deacetylase inhibitors in parasites: past, present, and future perspectives. 80
The nitrobenzoxadiazole derivative MC3181 blocks melanoma invasion and metastasis. 79
Histone Deacetylation in Epigenetics: An Attractive Target for Anticancer Therapy 78
The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene expression and inhibits histone deacetylases 78
Role of SIRT3 in Microgravity Response: A New Player in Muscle Tissue Recovery 77
Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC-MEF2 complexes. 77
Structure-based mechanism of riboregulation of the metabolic enzyme SHMT1 76
Histone deacetylase inhibitors and neurodegenerative disorders: Holding the promise 76
c-Jun N-terminal kinase activation by nitrobenzoxadiazoles leads to late-stage autophagy inhibition 76
Evaluation of a large library of (thiazol-2-yl)hydrazones and analogues as histone acetyltransferase inhibitors: Enzyme and cellular studies. 76
Docking and 3-D QSAR Studies on SIRT2 Inhibitors: A GRID/GOLPE Approach on Different Series of Compounds. 75
6-(Arylmethyl)pyrimidin-4(3H)-ones: Anthology and prospects of highly efficient anti-HIV agents 74
A novel orally active water-soluble inhibitor of human glutathione transferase exerts a potent and selective antitumor activity against human melanoma xenografts 74
Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells 74
Structure-reactivity relationships on substrates and inhibitors of the lysine deacylase sirtuin 2 from schistosoma mansoni (SmSirt2) 74
Sirtuin functions and modulation: from chemistry to the clinic 73
An Analog of BIX-01294 Selectively Inhibits a Family of Histone H3 Lysine 9 Jumonji Demethylases 73
Sirt5 inhibition induces brown fat-like phenotype in 3t3-l1 preadipocytes 73
A new nitrobenzoxadiazole-based GSTP1-1 inhibitor with a previously unheard of mechanism of action and high stability. 72
Tranylcypromine-based LSD1 inhibitors: structure-activity relationships, antiproliferative effects in leukemia, and gene target modulation 72
A novel Gcn5p inhibitor represses cell growth, gene transcription and histone acetylation in budding yeast 70
One-Pot, High Yielding Synthesis of Novel Dihydrothiazolo[3,2-a]pyrimidinones 70
Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features. 70
Nitric oxide modulates chromatin folding in human endothelial cells via protein phosphatase 2A activation and class II histone deacetylases nuclear shuttling 69
A Photoreactive Small-Molecule Probe for 2-Oxoglutarate Oxygenases 69
PARP-1 Modulates Amyloid Beta Peptide-Induced Neuronal Damage 69
Enzyme kinetics and inhibition of histone acetyltransferase KAT8 69
Synthesis and structure-activity relationship of new cytotoxic agents targeting human glutathione-S-transferases. 69
Identification of Inhibitors to trypanosoma cruzi sirtuins based on compounds developed to human enzymes 69
First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53 69
Benzodeazaoxaflavins as sirtuin inhibitors with antiproliferative properties in cancer stem cells. 68
PARP-1 inhibition decreases Beta-Amyloid-induced neurodegeneration: a cellular and animal model study 68
Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells. 68
A new water soluble MAPK activator exerts antitumor activity in melanoma cells resistant to the BRAF inhibitor vemurafenib 68
Class II-selective histone deacetylase inhibitors. Part 2: Alignment-independent GRIND 3-D QSAR, homology and docking studies 68
Discovery of uracil-based histone deacetylase inhibitors able to reduce acquired antifungal resistance and trailing growth in Candida albicans 67
Diarylpyrimidine-Dihydrobenzyloxopyrimidine Hybrids: New, Wide-Spectrum Anti-HIV-1 Agents Active at (Sub)-Nanomolar Level. 67
Synthesis and biological properties of novel 2-aminopyrimidin-4(3H)-ones highly potent against HIV-1 mutant strains 67
At long last potent and selective KDM5 inhibitors 66
Radioguided surgery with β− radiation in pancreatic Neuroendocrine tumors: a feasibility study 66
6-[1-(2,6-difluorophenyl)ethyl]pyrimidinones antagonize cell proliferation and induce cell differentiation by inhibiting (a nontelomeric) endogenous reverse transcriptase 66
6-Alkylthio-4-[1-(2,6-difluorophenyl)alkyl]-1H-[1,3,5]triazin-2-ones (ADATs): Novel Regulators of Cell Differentiation and Proliferation 65
Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases 65
Histone deacetylase inhibition modulates deoxyribonucleotide pools and enhances the antitumor effects of the ribonucleotide reductase inhibitor 3'-C-methyladenosine in leukaemia cells. 65
Shock and kill" effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence 65
Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in Schistosoma mansoni 65
From PARP1 to TNKS2 inhibition: A structure-based approach 64
Photoactivable peptides for identifying enzyme-substrate and protein-protein interactions. 63
Structural basis of sirtuin 6 activation by synthetic small molecules. 63
Synthesis and biological properties of novel, uracil-containing histone deacetylase inhibitors 63
Specific inhibitors of mitochondrial deacylase sirtuin 4 endowed with cellular activity 63
Biological Effects of MC2050, a Quinazoline-Based PARP-1 Inhibitor, in Human Neuroblastoma and EBV-Positive Burkitt's Lymphoma Cells 62
Small-Molecule Inhibitors of Histone Acetyltransferase Activity: Identification and Biological Properties 62
Targeting histone demethylases: A new avenue for the fight against cancer 60
Context-Selective Death of Acute Myeloid Leukemia Cells Triggered by the Novel Hybrid Retinoid-HDAC Inhibitor MC2392. 60
Reactions of 6-benzyl-5-methyl-2-(methylsulfanyl)pyrimidin-4(3H)-one with aliphatic and aliphatic-aromatic amines 60
CDK9 as a valuable target in cancer: from natural compounds inhibitors to current treatment in pediatric soft tissue sarcomas 60
Towards the development of activity-based probes for detection of lysine-specific demethylase-1 activity. 59
α,γ-Diketocarboxylic acids and their esters act as carbonic anhydrase IX and XII selective inhibitors 59
HDACs class II-selective inhibition alters nuclear receptor-dependent differentiation 59
Totale 7.918
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Categoria #
all - tutte 39.225
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 447
selected - selezionate 0
volume - volumi 0
Totale 39.672
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.295 0 0 0 0 0 0 347 275 293 169 114 97
2020/2021795 93 90 59 59 19 26 38 74 95 129 80 33
2021/20221.969 31 107 212 88 217 56 62 207 173 142 355 319
2022/20232.005 363 447 91 178 187 188 64 99 167 68 102 51
2023/20241.761 130 134 113 99 154 484 78 153 31 123 137 125
2024/20251.320 179 128 221 221 297 273 1 0 0 0 0 0
Totale 11.768