Catalogo dei prodotti della ricerca

ROTILI, Dante
 Distribuzione geografica
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Continente #
NA - Nord America 6.528
EU - Europa 2.444
AS - Asia 635
AF - Africa 40
SA - Sud America 39
Continente sconosciuto - Info sul continente non disponibili 3
OC - Oceania 2
Totale 9.691
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Nazione #
US - Stati Uniti d'America 6.483
IT - Italia 1.174
SE - Svezia 355
IN - India 314
CN - Cina 220
FI - Finlandia 185
GB - Regno Unito 160
UA - Ucraina 118
BG - Bulgaria 98
DE - Germania 92
SG - Singapore 61
IE - Irlanda 45
RO - Romania 43
BE - Belgio 42
CA - Canada 40
FR - Francia 38
AR - Argentina 36
ES - Italia 35
TG - Togo 30
NL - Olanda 20
HK - Hong Kong 18
AT - Austria 16
CH - Svizzera 9
ET - Etiopia 5
IL - Israele 5
KR - Corea 5
MX - Messico 5
JP - Giappone 4
PL - Polonia 4
EU - Europa 3
IR - Iran 3
CO - Colombia 2
DK - Danimarca 2
DZ - Algeria 2
GR - Grecia 2
NO - Norvegia 2
AL - Albania 1
AU - Australia 1
BY - Bielorussia 1
CI - Costa d'Avorio 1
CL - Cile 1
CZ - Repubblica Ceca 1
EG - Egitto 1
HR - Croazia 1
ID - Indonesia 1
JO - Giordania 1
KG - Kirghizistan 1
MY - Malesia 1
NZ - Nuova Zelanda 1
PK - Pakistan 1
ZA - Sudafrica 1
Totale 9.691
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Città #
Fairfield 1.171
Ashburn 662
Woodbridge 542
Rome 475
Houston 428
Seattle 417
Chandler 391
Cambridge 347
Wilmington 336
Ann Arbor 190
Princeton 186
San Paolo di Civitate 171
New York 152
Dearborn 135
Lawrence 128
Plano 109
Sofia 97
Beijing 94
San Diego 94
Millbury 89
Helsinki 82
Boston 77
Andover 56
Monte Cremasco 49
Des Moines 48
Dublin 42
Federal 34
Jacksonville 34
Washington 34
Lomé 30
Fasano 26
Toronto 26
Milan 25
Boardman 21
Singapore 21
Norwalk 20
Barcelona 19
Bühl 17
Deurne 16
Kunming 16
Nanjing 16
Hefei 15
Bologna 14
Bremen 14
London 14
Los Angeles 14
Naples 14
Vienna 14
Phoenix 13
Caserta 12
Falls Church 12
Leuven 11
Pune 11
Palermo 10
Brussels 9
Jinan 9
Lappeenranta 9
Ottawa 9
Shanghai 9
Paris 8
Florence 7
Grafing 7
Guangzhou 7
Perugia 7
Pessac 7
Philadelphia 7
Fremont 6
Leipzig 6
Nanchang 6
Paderno Dugnano 6
Sacramento 6
Sulmona 6
Treviso 6
Turin 6
Venezia 6
Chengdu 5
Chongqing 5
Laurel 5
Madrid 5
Mexico City 5
Mountain View 5
New Delhi 5
Nocera Inferiore 5
Pallejà 5
San Mateo 5
Amsterdam 4
Auburn Hills 4
Bern 4
Brescia 4
Chicago 4
Denver 4
Giv‘atayim 4
Hebei 4
Indiana 4
Miami 4
Redmond 4
San Francisco 4
San Jose 4
Siena 4
Stockholm 4
Totale 7.350
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Nome #
Mass spectrometry characterization of DOTA-Nimotuzumab conjugate as precursor of an innovative β − tracer suitable in radio-guided surgery 112
Disruptor of telomeric silencing 1-like (DOT1L): disclosing a new class of non-nucleoside inhibitors by means of ligand-based and structure-based approaches 108
Hydrophilic gold nanoparticles as Anti-PD-L1 antibody carriers. Synthesis and interface properties 107
Identification of small molecules inhibitors of GCN5 histone acetyltransferase activity 106
SIRT5 regulation of ammonia-induced autophagy and mitophagy 105
RIP1-HAT1-SirT complex identification and targeting in treatment and prevention of cancer 103
Effect of α-methoxy substitution on the anti-HIV activity of dihydropyrimidin-4(3 H)-ones 102
2-(Alkyl/aryl)amino-6-benzylpyrimidin-4(3H)-ones as inhibitors of wild-type and mutant HIV-1: enantioselectivity studies. 99
Feasibility of beta-particle radioguided surgery for a variety of “nuclear medicine” radionuclides 98
Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma. 96
Y3+ embedded in polymeric nanoparticles: Morphology, dimension and stability of composite colloidal system 96
The histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces cardiac arrhythmias in dystrophic mice 95
Novel pyrrole-containing histone deacetylase inhibitors endowed with cytodifferentiation activity 90
Development of 1,2,4-oxadiazoles as potent and selective inhibitors of the human deacetylase sirtuin 2: structure-activity relationship, X-ray crystal structure, and anticancer activity 88
Chiral HPLC separation and absolute configuration of novel S-DABO derivatives. 88
5-Alkyl-6-benzyl-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones, a series of anti-HIV-1 agents of the dihydro-alkoxy-benzyl-oxopyrimidine family with peculiar structure-activity relationship profile. 86
Gold nanoparticles and nanorods in nuclear medicine: a mini review 85
Exploring the role of 2-chloro-6-fluoro substitution in 2-alkylthio-6-benzyl-5-alkylpyrimidin-4(3H)-ones: effects in HIV-1-infected cells and in HIV-1 reverse transcriptase enzymes 84
Pyrrole- and indole-containing tranylcypromine derivatives as novel lysine-specific demethylase 1 inhibitors active on cancer cells. 82
Nitric oxide determines mesodermic differentiation of mouse embryonic stem cells by activating class IIa histone deacetylases: potential therapeutic implications in a mouse model of hindlimb ischemia 81
Characterization of Sirtuin Inhibitors in Nematodes Expressing a Muscular Dystrophy Protein Reveals Muscle Cell and Behavioral Protection by Specific Sirtinol Analogues 81
Identification of novel quinazoline derivatives as potent antiplasmodial agents 81
Histone acetyltransferase inhibitor CPTH6 preferentially targets lung cancer stem-like cells 81
Quinoline-based p300 histone acetyltransferase inhibitors with pro-apoptotic activity in human leukemia U937 cells. 80
Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features 80
Proteomic profile of differentially expressed plasma proteins from dystrophic mice and following suberoylanilide hydroxamic acid treatment 79
Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells 79
Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities 77
Carprofen Analogues as Sirtuin Inhibitors: Enzyme and Cellular Studies 77
Multimodal evaluation of 19F-BPA internalization in pancreatic cancer cells for boron capture and proton therapy potential applications 77
The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene expression and inhibits histone deacetylases 76
Epigenetic polypharmacology: a new frontier for epi-drug discovery 76
Histone deacetylase inhibitors and neurodegenerative disorders: Holding the promise 75
The relevance of Ki calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor. 75
Lysine acetyltransferase inhibitors: structure-activity relationships and potential therapeutic implications 75
The nitrobenzoxadiazole derivative MC3181 blocks melanoma invasion and metastasis. 75
Lysine deacetylase inhibitors in parasites: past, present, and future perspectives. 75
Biochemical functions and clinical characterizations of the sirtuins in diabetes-induced retinal pathologies 75
Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC-MEF2 complexes. 74
Histone Deacetylation in Epigenetics: An Attractive Target for Anticancer Therapy 74
KAT3B-p300 and H3AcK18/H3AcK14 levels are prognostic markers for kidney ccRCC tumor aggressiveness and target of KAT inhibitor CPTH2 74
c-Jun N-terminal kinase activation by nitrobenzoxadiazoles leads to late-stage autophagy inhibition 73
90Y-DOTA-nimotuzumab: synthesis of a promising β⁻ radiopharmaceutical 73
Properly substituted analogues of BIX-01294 lose inhibition of G9a histone methyltransferase and gain selective anti-DNA methyltransferase 3A activity. 72
Neuroprotective effects of PARP inhibitors in Drosophila models of Alzheimer’s disease 71
Docking and 3-D QSAR Studies on SIRT2 Inhibitors: A GRID/GOLPE Approach on Different Series of Compounds. 70
6-(Arylmethyl)pyrimidin-4(3H)-ones: Anthology and prospects of highly efficient anti-HIV agents 70
Sirtuin functions and modulation: from chemistry to the clinic 70
Evaluation of a large library of (thiazol-2-yl)hydrazones and analogues as histone acetyltransferase inhibitors: Enzyme and cellular studies. 70
An Analog of BIX-01294 Selectively Inhibits a Family of Histone H3 Lysine 9 Jumonji Demethylases 70
Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells 69
Structure-reactivity relationships on substrates and inhibitors of the lysine deacylase sirtuin 2 from schistosoma mansoni (SmSirt2) 69
One-Pot, High Yielding Synthesis of Novel Dihydrothiazolo[3,2-a]pyrimidinones 67
A novel orally active water-soluble inhibitor of human glutathione transferase exerts a potent and selective antitumor activity against human melanoma xenografts 67
A new nitrobenzoxadiazole-based GSTP1-1 inhibitor with a previously unheard of mechanism of action and high stability. 67
Diarylpyrimidine-Dihydrobenzyloxopyrimidine Hybrids: New, Wide-Spectrum Anti-HIV-1 Agents Active at (Sub)-Nanomolar Level. 66
A Photoreactive Small-Molecule Probe for 2-Oxoglutarate Oxygenases 66
Benzodeazaoxaflavins as sirtuin inhibitors with antiproliferative properties in cancer stem cells. 66
PARP-1 Modulates Amyloid Beta Peptide-Induced Neuronal Damage 66
Enzyme kinetics and inhibition of histone acetyltransferase KAT8 66
Synthesis and structure-activity relationship of new cytotoxic agents targeting human glutathione-S-transferases. 66
Class II-selective histone deacetylase inhibitors. Part 2: Alignment-independent GRIND 3-D QSAR, homology and docking studies 66
PARP-1 inhibition decreases Beta-Amyloid-induced neurodegeneration: a cellular and animal model study 65
Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells. 65
Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features. 65
Nitric oxide modulates chromatin folding in human endothelial cells via protein phosphatase 2A activation and class II histone deacetylases nuclear shuttling 64
Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases 63
6-[1-(2,6-difluorophenyl)ethyl]pyrimidinones antagonize cell proliferation and induce cell differentiation by inhibiting (a nontelomeric) endogenous reverse transcriptase 63
A novel Gcn5p inhibitor represses cell growth, gene transcription and histone acetylation in budding yeast 62
Structural basis of sirtuin 6 activation by synthetic small molecules. 62
Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in Schistosoma mansoni 62
Synthesis and biological properties of novel 2-aminopyrimidin-4(3H)-ones highly potent against HIV-1 mutant strains 62
Role of SIRT3 in Microgravity Response: A New Player in Muscle Tissue Recovery 61
Discovery of uracil-based histone deacetylase inhibitors able to reduce acquired antifungal resistance and trailing growth in Candida albicans 61
Photoactivable peptides for identifying enzyme-substrate and protein-protein interactions. 61
A new water soluble MAPK activator exerts antitumor activity in melanoma cells resistant to the BRAF inhibitor vemurafenib 61
Tranylcypromine-based LSD1 inhibitors: structure-activity relationships, antiproliferative effects in leukemia, and gene target modulation 61
6-Alkylthio-4-[1-(2,6-difluorophenyl)alkyl]-1H-[1,3,5]triazin-2-ones (ADATs): Novel Regulators of Cell Differentiation and Proliferation 60
Histone deacetylase inhibition modulates deoxyribonucleotide pools and enhances the antitumor effects of the ribonucleotide reductase inhibitor 3'-C-methyladenosine in leukaemia cells. 60
At long last potent and selective KDM5 inhibitors 60
Radioguided surgery with β− radiation in pancreatic Neuroendocrine tumors: a feasibility study 60
Enhancing sensitivity of triple-negative breast cancer to DNA-damaging therapy through chemical inhibition of the m6A methyltransferase METTL3 59
Biological Effects of MC2050, a Quinazoline-Based PARP-1 Inhibitor, in Human Neuroblastoma and EBV-Positive Burkitt's Lymphoma Cells 59
Towards the development of activity-based probes for detection of lysine-specific demethylase-1 activity. 59
Reactions of 6-benzyl-5-methyl-2-(methylsulfanyl)pyrimidin-4(3H)-one with aliphatic and aliphatic-aromatic amines 59
From PARP1 to TNKS2 inhibition: A structure-based approach 59
Synthesis and biological properties of novel, uracil-containing histone deacetylase inhibitors 59
First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53 59
Targeting histone demethylases: A new avenue for the fight against cancer 58
Shock and kill" effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence 58
Identification of Inhibitors to trypanosoma cruzi sirtuins based on compounds developed to human enzymes 58
Context-Selective Death of Acute Myeloid Leukemia Cells Triggered by the Novel Hybrid Retinoid-HDAC Inhibitor MC2392. 57
Sirtuins as drug targets 57
HDACs class II-selective inhibition alters nuclear receptor-dependent differentiation 57
CDK9 as a valuable target in cancer: from natural compounds inhibitors to current treatment in pediatric soft tissue sarcomas 57
Novel uracil-based 2-aminoanilide and 2-aminoanilide-like derivatives: Histone deacetylase inhibition and in-cell activities 57
Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides 55
Substrate-induced stable enzyme-inhibitor complex formation allows tight binding of novel 2-aminopyrimidin-4(3H)-ones to drug-resistant HIV-1 reverse transcriptase mutants. 55
Small-Molecule Inhibitors of Histone Acetyltransferase Activity: Identification and Biological Properties 55
Simplification of the tetracyclic SIRT1-selective inhibitor MC2141: Coumarin- and pyrimidine-based SIRT1/2 inhibitors with different selectivity profile 54
Totale 7.236
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Categoria #
all - tutte 27.342
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 308
selected - selezionate 0
volume - volumi 0
Totale 27.650
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019738 0 0 0 0 0 0 0 0 0 0 420 318
2019/20202.273 240 78 29 91 210 330 347 275 293 169 114 97
2020/2021795 93 90 59 59 19 26 38 74 95 129 80 33
2021/20221.969 31 107 212 88 217 56 62 207 173 142 355 319
2022/20232.005 363 447 91 178 187 188 64 99 167 68 102 51
2023/20241.531 130 134 113 99 154 484 83 163 32 125 14 0
Totale 10.218