Histone lysine demethylase 5 enzymes (KDM5s) have recently been proposed as crucial oncogenic drivers. In this issue of Cell Chemical Biology, Horton et al. (2016) describe results of an extensive structural analysis that reveals how distinct inhibitor chemotypes bind KDM5 and suggest avenues for improving KDM5 inhibitory potency and selectivity.
At long last potent and selective KDM5 inhibitors / Rotili, Dante; Mattevi, Andrea. - In: CELL CHEMICAL BIOLOGY. - ISSN 2451-9456. - STAMPA. - 23:7(2016), pp. 749-751. [10.1016/j.chembiol.2016.07.003]
At long last potent and selective KDM5 inhibitors
ROTILI, Dante;
2016
Abstract
Histone lysine demethylase 5 enzymes (KDM5s) have recently been proposed as crucial oncogenic drivers. In this issue of Cell Chemical Biology, Horton et al. (2016) describe results of an extensive structural analysis that reveals how distinct inhibitor chemotypes bind KDM5 and suggest avenues for improving KDM5 inhibitory potency and selectivity.File allegati a questo prodotto
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