Sirtuins are NAD+ -dependent histone deacetylases regulating important metabolic pathways in prokaryotes and eukaryotes and are involved in many biological processes such as cell survival, senescence, proliferation, apoptosis, DNA repair, cell metabolism, and caloric restriction. The seven members of this family of enzymes are considered potential targets for the treatment of human pathologies including neurodegenerative diseases, cardiovascular diseases, and cancer. Furthermore, recent interest focusing on sirtuin modulators as epigenetic players in the regulation of fundamental biological pathways has prompted increased efforts to discover new small molecules able to modify sirtuin activity. Here, we review the role, mechanism of action, and biological function of the seven sirtuins, as well as their inhibitors and activators.

Sirtuin functions and modulation: from chemistry to the clinic / Carafa, Vincenzo; Rotili, Dante; Forgione, Mariantonietta; Cuomo, Francesca; Serretiello, Enrica; Hailu, GEBREMEDHIN SOLOMON; Jarho, Elina; Lahtela Kakkonen, Maija; Mai, Antonello; Altucci, Lucia. - In: CLINICAL EPIGENETICS. - ISSN 1868-7083. - 8:1(2016), pp. 1-21. [10.1186/s13148-016-0224-3]

Sirtuin functions and modulation: from chemistry to the clinic

ROTILI, Dante;FORGIONE, MARIANTONIETTA;HAILU, GEBREMEDHIN SOLOMON;MAI, Antonello
;
2016

Abstract

Sirtuins are NAD+ -dependent histone deacetylases regulating important metabolic pathways in prokaryotes and eukaryotes and are involved in many biological processes such as cell survival, senescence, proliferation, apoptosis, DNA repair, cell metabolism, and caloric restriction. The seven members of this family of enzymes are considered potential targets for the treatment of human pathologies including neurodegenerative diseases, cardiovascular diseases, and cancer. Furthermore, recent interest focusing on sirtuin modulators as epigenetic players in the regulation of fundamental biological pathways has prompted increased efforts to discover new small molecules able to modify sirtuin activity. Here, we review the role, mechanism of action, and biological function of the seven sirtuins, as well as their inhibitors and activators.
2016
cancer; drug discovery; epigenetics; neurodegeneration; SIRT modulators; sirtuins; genetics; molecular biology; developmental biology; genetics (clinical)
01 Pubblicazione su rivista::01a Articolo in rivista
Sirtuin functions and modulation: from chemistry to the clinic / Carafa, Vincenzo; Rotili, Dante; Forgione, Mariantonietta; Cuomo, Francesca; Serretiello, Enrica; Hailu, GEBREMEDHIN SOLOMON; Jarho, Elina; Lahtela Kakkonen, Maija; Mai, Antonello; Altucci, Lucia. - In: CLINICAL EPIGENETICS. - ISSN 1868-7083. - 8:1(2016), pp. 1-21. [10.1186/s13148-016-0224-3]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/884147
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