HAILU, GEBREMEDHIN SOLOMON
HAILU, GEBREMEDHIN SOLOMON
DIPARTIMENTO DI CHIMICA E TECNOLOGIE DEL FARMACO
Design, synthesis and biological evaluation of novel epigenetic modulators for parasitic diseases
2017 Hailu, GEBREMEDHIN SOLOMON
Deubiquitinase-targeting chimeras (DUBTACs). A game-changing approach for targeted protein stabilization in drug discovery
2026 Hailu, Gebremedhin Solomon; Fabbrizi, Emanuele; Mancini, Andrea; Fiorentino, Francesco; Mai, Antonello; Rotili, Dante
Development of 1,2,4-oxadiazoles as potent and selective inhibitors of the human deacetylase sirtuin 2: structure-activity relationship, X-ray crystal structure, and anticancer activity
2017 Moniot, S; Forgione, M; Lucidi, Alessia; Hailu, GEBREMEDHIN SOLOMON; Nebbioso, A; Carafa, V; Baratta, F; Altucci, L; Giacché, N; Passeri, D; Pellicciari, R; Mai, Antonello; Steegborn, C; Rotili, Dante
Effect of α-methoxy substitution on the anti-HIV activity of dihydropyrimidin-4(3 H)-ones
2019 Nawrozkij, Maxim B.; Forgione, Mariantonietta; Yablokov, Alexandre S.; Lucidi, Alessia; Tomaselli, Daniela; Patsilinakos, Alexandros; Panella, Cristina; Hailu, Gebremedhin S.; Kirillov, Ivan A.; Badia, Roger; Riveira-Munoz, Eva; Crespan, Emmanuele; Armijos Rivera, Jorge I.; Cirilli, Roberto; Ragno, Rino; Esté, José A.; Maga, Giovanni; Mai, Antonello; Rotili, Dante
Exploring the role of conformational restriction in 5-alkyl-6-benzyl-2-{[(methylthio)methyl]thio}pyrimidin-4(3H)-ones. Effects in HIV-1 infected cells and reverse transcriptase enzymes
2026 Degtyarenko, Egor; Hailu, Gebremedhin Solomon; Fabbrizi, Emanuele; Golovina, Anastasia; Voronkov, Andrey; Astolfi, Roberta; Giuliani, Lidia; Mancini, Andrea; Nawrozkij, Maxim B; Chernyshov, Vladimir; Pupillo, Clarissa; Cirilli, Roberto; Bavagnoli, Laura; Ragno, Rino; Esté, José A; Crespan, Emmanuele; Fiorentino, Francesco; Ivanov, Roman; Mai, Antonello; Rotili, Dante
Lysine deacetylase inhibitors in parasites: past, present, and future perspectives.
2017 Hailu, Gs; Robaa, D; Forgione, M; Sippl, W; Rotili, D; Mai, A.
METTL1/WDR4 Complex: A Novel Epitranscriptomic Target at the Crossroads of RNA Methylation and Drug Discovery
2026 Fabbrizi, Emanuele; Hailu, Gebremedhin Solomon; Mancini, Andrea; Mai, Antonello; Fiorentino, Francesco; Rotili, Dante
Sirtuin functions and modulation: from chemistry to the clinic
2016 Carafa, Vincenzo; Rotili, Dante; Forgione, Mariantonietta; Cuomo, Francesca; Serretiello, Enrica; Hailu, GEBREMEDHIN SOLOMON; Jarho, Elina; Lahtela Kakkonen, Maija; Mai, Antonello; Altucci, Lucia
Systematic structure–activity relationship investigation on novel 5-alkyl-6-benzyl-2-{[(methylthio/phenylthio)alkyl]thio}-pyrimidin-4(3H)-ones endowed with potent anti-hiv-1 activity
2026 Hailu, Gebremedhin Solomon; Degtyarenko, Egor; Fabbrizi, Emanuele; Golovina, Anastasia; Voronkov, Andrey; Mancini, Andrea; Nawrozkij, Maxim B.; Chernyshov, Vladimir; Bavagnoli, Laura; Bianchi, Elena; Astolfi, Roberta; Ragno, Rino; Esté, José A.; Crespan, Emmanuele; Fiorentino, Francesco; Ivanov, Roman; Mai, Antonello; Rotili, Dante
The relevance of Ki calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor.
2017 Wapenaar, H; van den Bosch, T; Leus, Ngj; van der Wouden, Pe; Eleftheriadis, N; Hermans, J; Hailu, Gs; Rotili, D; Mai, A; Dömling, A; Bischoff, R; Haisma, Hj; Dekker, F. J.
Tranylcypromine-Based LSD1 Inhibitors as Useful Agents to Reduce Viability of Schistosoma mansoni
2025 Fabbrizi, Emanuele; Hailu, Gebremedhin Solomon; Ganesan, A.; Fioravanti, Rossella; Zwergel, Clemens; Lambona, Chiara; Valente, Sergio; Fianco, Giulia; Iuzzolino, Angela; Trisciuoglio, Daniela; Caroli, Jonatan; Mattevi, Andrea; Häberli, Cécile; Keiser, Jennifer; Rotili, Dante; Mai, Antonello
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| Design, synthesis and biological evaluation of novel epigenetic modulators for parasitic diseases | 2017 | Hailu, GEBREMEDHIN SOLOMON | |
| Deubiquitinase-targeting chimeras (DUBTACs). A game-changing approach for targeted protein stabilization in drug discovery | 2026 | Hailu, Gebremedhin Solomon; Fabbrizi, Emanuele; Mancini, Andrea; Fiorentino, Francesco; Mai, Antonello; Rotili, Dante | |
| Development of 1,2,4-oxadiazoles as potent and selective inhibitors of the human deacetylase sirtuin 2: structure-activity relationship, X-ray crystal structure, and anticancer activity | 2017 | Moniot, S; Forgione, M; Lucidi, Alessia; Hailu, GEBREMEDHIN SOLOMON; Nebbioso, A; Carafa, V; Baratta, F; Altucci, L; Giacché, N; Passeri, D; Pellicciari, R; Mai, Antonello; Steegborn, C; Rotili, Dante | |
| Effect of α-methoxy substitution on the anti-HIV activity of dihydropyrimidin-4(3 H)-ones | 2019 | Nawrozkij, Maxim B.; Forgione, Mariantonietta; Yablokov, Alexandre S.; Lucidi, Alessia; Tomaselli, Daniela; Patsilinakos, Alexandros; Panella, Cristina; Hailu, Gebremedhin S.; Kirillov, Ivan A.; Badia, Roger; Riveira-Munoz, Eva; Crespan, Emmanuele; Armijos Rivera, Jorge I.; Cirilli, Roberto; Ragno, Rino; Esté, José A.; Maga, Giovanni; Mai, Antonello; Rotili, Dante | |
| Exploring the role of conformational restriction in 5-alkyl-6-benzyl-2-{[(methylthio)methyl]thio}pyrimidin-4(3H)-ones. Effects in HIV-1 infected cells and reverse transcriptase enzymes | 2026 | Degtyarenko, Egor; Hailu, Gebremedhin Solomon; Fabbrizi, Emanuele; Golovina, Anastasia; Voronkov, Andrey; Astolfi, Roberta; Giuliani, Lidia; Mancini, Andrea; Nawrozkij, Maxim B; Chernyshov, Vladimir; Pupillo, Clarissa; Cirilli, Roberto; Bavagnoli, Laura; Ragno, Rino; Esté, José A; Crespan, Emmanuele; Fiorentino, Francesco; Ivanov, Roman; Mai, Antonello; Rotili, Dante | |
| Lysine deacetylase inhibitors in parasites: past, present, and future perspectives. | 2017 | Hailu, Gs; Robaa, D; Forgione, M; Sippl, W; Rotili, D; Mai, A. | |
| METTL1/WDR4 Complex: A Novel Epitranscriptomic Target at the Crossroads of RNA Methylation and Drug Discovery | 2026 | Fabbrizi, Emanuele; Hailu, Gebremedhin Solomon; Mancini, Andrea; Mai, Antonello; Fiorentino, Francesco; Rotili, Dante | |
| Sirtuin functions and modulation: from chemistry to the clinic | 2016 | Carafa, Vincenzo; Rotili, Dante; Forgione, Mariantonietta; Cuomo, Francesca; Serretiello, Enrica; Hailu, GEBREMEDHIN SOLOMON; Jarho, Elina; Lahtela Kakkonen, Maija; Mai, Antonello; Altucci, Lucia | |
| Systematic structure–activity relationship investigation on novel 5-alkyl-6-benzyl-2-{[(methylthio/phenylthio)alkyl]thio}-pyrimidin-4(3H)-ones endowed with potent anti-hiv-1 activity | 2026 | Hailu, Gebremedhin Solomon; Degtyarenko, Egor; Fabbrizi, Emanuele; Golovina, Anastasia; Voronkov, Andrey; Mancini, Andrea; Nawrozkij, Maxim B.; Chernyshov, Vladimir; Bavagnoli, Laura; Bianchi, Elena; Astolfi, Roberta; Ragno, Rino; Esté, José A.; Crespan, Emmanuele; Fiorentino, Francesco; Ivanov, Roman; Mai, Antonello; Rotili, Dante | |
| The relevance of Ki calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor. | 2017 | Wapenaar, H; van den Bosch, T; Leus, Ngj; van der Wouden, Pe; Eleftheriadis, N; Hermans, J; Hailu, Gs; Rotili, D; Mai, A; Dömling, A; Bischoff, R; Haisma, Hj; Dekker, F. J. | |
| Tranylcypromine-Based LSD1 Inhibitors as Useful Agents to Reduce Viability of Schistosoma mansoni | 2025 | Fabbrizi, Emanuele; Hailu, Gebremedhin Solomon; Ganesan, A.; Fioravanti, Rossella; Zwergel, Clemens; Lambona, Chiara; Valente, Sergio; Fianco, Giulia; Iuzzolino, Angela; Trisciuoglio, Daniela; Caroli, Jonatan; Mattevi, Andrea; Häberli, Cécile; Keiser, Jennifer; Rotili, Dante; Mai, Antonello |