Radiolabeled nanoparticles are promising tools in cancer diagnosis and therapy. Moreover, yttrium-90 (90Y) is a good candidate as suitable β− emitting radioisotope for a new approach to radio-guided surgery (RGS) proposed by some researchers of our group. In this work, we developed new composite nanoparticles, based on polymethylmethacrylate (PMMA), and poly(methylmethacrylate-co-acrylic acid), P(MMA/AA), embedded with yttrium ion (89Y3+), as a first step for the development of new 90Y3+ based nanocomposites. The composite nanoparticles were synthesised by emulsion polymerization technique, in the presence of potassium persulfate (KPS) as radical initiator, toluene as cosolvent, diethylenetriamine penta acetic acid dianhydride (DTPA) as chelating agent, using different MMA/89Y3+ molar ratios. The yttrium doped polymeric nanoparticles were characterized by means of FTIR spectroscopy, SEM-EDX, AFM, and DLS measurements. The influence of experimental parameters, such as cosolvent and reaction time, on morphology and dimension of composite nanoparticles was investigated, and monodispersed nanospheres with diameters from 20 nm to 400 nm were obtained. The composite material was purified and studied by means of DLS to confirm the colloid stability in water solution at different temperatures (25 °C and 37 °C) up to 3 weeks. © 2017 Elsevier B.V.
Y3+ embedded in polymeric nanoparticles: Morphology, dimension and stability of composite colloidal system / Venditti, I; Cartoni, A.; Fontana, L.; Testa, G.; Scaramuzzo, F. A.; Faccini, R.; Mancini Terracciano, C.; Solfaroli Camillocci, E.; Morganti, S.; Giordano, A.; Scotognella, T.; Rotili, D.; Dini, V.; Marini, F.; Fratoddi, I. - In: COLLOIDS AND SURFACES. A, PHYSICOCHEMICAL AND ENGINEERING ASPECTS. - ISSN 0927-7757. - STAMPA. - 532:(2017), pp. 125-131. [10.1016/j.colsurfa.2017.05.082]
Y3+ embedded in polymeric nanoparticles: Morphology, dimension and stability of composite colloidal system
Cartoni, A.;Scaramuzzo, F. A.;Faccini, R.;Mancini Terracciano, C.;Rotili, D.;Fratoddi, I
2017
Abstract
Radiolabeled nanoparticles are promising tools in cancer diagnosis and therapy. Moreover, yttrium-90 (90Y) is a good candidate as suitable β− emitting radioisotope for a new approach to radio-guided surgery (RGS) proposed by some researchers of our group. In this work, we developed new composite nanoparticles, based on polymethylmethacrylate (PMMA), and poly(methylmethacrylate-co-acrylic acid), P(MMA/AA), embedded with yttrium ion (89Y3+), as a first step for the development of new 90Y3+ based nanocomposites. The composite nanoparticles were synthesised by emulsion polymerization technique, in the presence of potassium persulfate (KPS) as radical initiator, toluene as cosolvent, diethylenetriamine penta acetic acid dianhydride (DTPA) as chelating agent, using different MMA/89Y3+ molar ratios. The yttrium doped polymeric nanoparticles were characterized by means of FTIR spectroscopy, SEM-EDX, AFM, and DLS measurements. The influence of experimental parameters, such as cosolvent and reaction time, on morphology and dimension of composite nanoparticles was investigated, and monodispersed nanospheres with diameters from 20 nm to 400 nm were obtained. The composite material was purified and studied by means of DLS to confirm the colloid stability in water solution at different temperatures (25 °C and 37 °C) up to 3 weeks. © 2017 Elsevier B.V.File | Dimensione | Formato | |
---|---|---|---|
Venditti_Y3+embedded_2017.pdf
solo gestori archivio
Note: full text - editor version
Tipologia:
Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza:
Tutti i diritti riservati (All rights reserved)
Dimensione
859.47 kB
Formato
Adobe PDF
|
859.47 kB | Adobe PDF | Contatta l'autore |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.