Catalogo dei prodotti della ricerca

ZWERGEL, CLEMENS
 Distribuzione geografica
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Continente #
NA - Nord America 2.644
EU - Europa 1.124
AS - Asia 297
AF - Africa 24
SA - Sud America 14
Continente sconosciuto - Info sul continente non disponibili 1
Totale 4.104
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Nazione #
US - Stati Uniti d'America 2.617
IT - Italia 563
SE - Svezia 160
IN - India 124
DE - Germania 87
CN - Cina 67
FI - Finlandia 65
SG - Singapore 65
BG - Bulgaria 63
GB - Regno Unito 51
ES - Italia 29
CA - Canada 22
UA - Ucraina 22
TG - Togo 21
FR - Francia 16
TR - Turchia 16
IE - Irlanda 15
RO - Romania 14
NL - Olanda 11
AR - Argentina 9
BE - Belgio 9
IR - Iran 7
PK - Pakistan 7
RU - Federazione Russa 6
MX - Messico 5
CH - Svizzera 4
HK - Hong Kong 4
BR - Brasile 3
CZ - Repubblica Ceca 3
AT - Austria 2
GR - Grecia 2
UZ - Uzbekistan 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AL - Albania 1
AM - Armenia 1
AZ - Azerbaigian 1
BD - Bangladesh 1
CI - Costa d'Avorio 1
CL - Cile 1
CO - Colombia 1
DZ - Algeria 1
EG - Egitto 1
KH - Cambogia 1
KR - Corea 1
LV - Lettonia 1
Totale 4.104
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Città #
Fairfield 453
Ashburn 367
Rome 270
Woodbridge 187
Houston 179
Chandler 173
Cambridge 142
Seattle 138
Wilmington 136
Ann Arbor 65
Sofia 63
San Paolo di Civitate 62
Princeton 61
Lawrence 52
Dearborn 46
Helsinki 46
Washington 43
San Diego 39
Millbury 36
New York 36
Plano 36
Beijing 24
Andover 22
Lomé 21
Norwalk 19
Singapore 19
Boston 18
Dublin 15
Mentana 13
Des Moines 12
Istanbul 12
Ottawa 12
Phoenix 10
Federal 9
Toronto 9
Milan 8
Badajoz 7
Berlin 7
Fiuggi 7
Frankfurt am Main 7
Nanjing 7
Amsterdam 6
Fasano 6
Barcelona 5
Boardman 5
Brussels 5
Bühl 5
Grafing 5
Jacksonville 5
Monte Cremasco 5
San Mateo 5
Valenza 5
Acquaviva delle Fonti 4
Bilbao 4
Bremen 4
Deurne 4
Eskişehir 4
Falls Church 4
Fremont 4
Hefei 4
Hong Kong 4
Lahore 4
Latina 4
Los Angeles 4
Mexico City 4
Nanchang 4
Perugia 4
Pozzuoli 4
Redwood City 4
Salamanca 4
Salerno 4
Viterbo 4
Arzano 3
Fara Gera d'Adda 3
Florence 3
Fuzhou 3
Giugliano in Campania 3
Kurukshetra 3
Mashhad 3
Montespertoli 3
Mumbai 3
Munich 3
Naples 3
Novara 3
Paris 3
Pune 3
Sabaudia 3
Tappahannock 3
Taranto 3
Uppsala 3
Villiers-sur-marne 3
Zurich 3
Albissola Marina 2
Alcorcón 2
Bari 2
Castiglione del Lago 2
Cerveteri 2
Civitavecchia 2
Fiano Romano 2
Groningen 2
Totale 3.101
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Nome #
Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells 164
The histone methyltransferase EZH2 as a druggable target in SHH medulloblastoma cancer stem cells 145
Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells 122
1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells 119
The emerging role of epigenetics in human autoimmune disorders 115
Novel inhibitors of human histone deacetylases: Design, synthesis and bioactivity of 3-alkenoylcoumarines 97
HDAC1 inhibition by MS-275 in mesothelial cells limits cellular invasion and promotes MMT reversal 97
Novel quinoline compounds active in cancer cells through coupled DNA methyltransferase inhibition and degradation 97
Design of first-in-class dual EZH2/HDAC inhibitor: biochemical activity and biological evaluation in cancer cells 91
Application of small epigenetic modulators in pediatric medulloblastoma 89
MC1568 inhibits HDAC6/8 activity and influenza A virus replication in lung epithelial cells: Role of Hsp90 acetylation 87
Acute and chronic neurobehavioral effects of the designer drug and bath salt constituent 3,4-methylenedioxypyrovalerone in the rat 86
Discovery of the first human arylsulfatase a reversible inhibitor impairing mouse oocyte fertilization 86
Inhibition of PKCθ Improves Dystrophic Heart Phenotype and Function in a Novel Model of DMD Cardiomyopathy 86
Effects of class II-selective histone deacetylase inhibitor on neuromuscular function and disease progression in SOD1-ALS mice 83
Aurones: Interesting Natural and Synthetic Compounds with Emerging Biological Potential 82
Novel coumarin- and quinolinone-based polycycles as cell division cycle 25-A and -C phosphatases inhibitors induce proliferation arrest and apoptosis in cancer cells 82
Pyrazole-based inhibitors of enhancer of zeste homologue 2 induce apoptosis and autophagy in cancer cells 79
Epi-drugs in combination with immunotherapy: a new avenue to improve anticancer efficacy 78
EZH2 inhibitors: a patent review (2014-2016) 77
Amphetamine and the Smart Drug 3,4-Methylenedioxypyrovalerone (MDPV) Induce Generalization of Fear Memory in Rats 77
Histone deacetylase inhibitors restore IL-10 expression in lipopolysaccharide-induced cell inflammation and reduce IL-1β and IL-6 production in breast silicone implant in C57BL/6J wild-type murine model 76
Six years (2012-2018) of researches on catalytic EZH2 inhibitors: the boom of the 2-pyridone compounds 72
Emerging approaches for histone deacetylase inhibitor drug discovery 71
Abstract 2946: Effects of two novel quinoline-based non-nucleoside DNA methyltransferase inhibitors against bone sarcomas 70
LSD1 inhibitors: a patent review (2010-2015) 70
Amphetamine modulation of long-term object recognition memory in rats: influence of stress 70
A quinoline-based DNA methyltransferase inhibitor as a possible adjuvant in osteosarcoma therapy 69
Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells 69
DNA methyltransferases Inhibitors from natural sources 66
Effect of Class II HDAC inhibition on glutamate transporter expression and survival in SOD1-ALS mice 66
Trends of LSD1 inhibitors in viral infections 65
One-pot synthesis of benzopyran-4-ones with cancer preventive and therapeutic potential 63
Tranylcypromine-based LSD1 inhibitors: structure-activity relationships, antiproliferative effects in leukemia, and gene target modulation 63
Detrimental effects of the 'bath salt' methylenedioxypyrovalerone on social play behavior in male rats 62
The innovative potential of selenium-containing agents for fighting cancer and viral infections 62
Reactivity of 4-vinyl-2H-1-benzopyran-2-ones in diels-alder cycloaddition reactions: Access to coumarin-based polycycles with Cdc25 phosphatase-inhibiting activity 59
Towards the development of activity-based probes for detection of lysine-specific demethylase-1 activity. 59
Nucleocytoplasmic export of HDAC5 and SIRT2 downregulation: two epigenetic mechanisms by which antidepressants enhance synaptic plasticity markers 58
Epigenetic Pharmacology in Regenerative Medicine (Epi-Drugs) 58
Sirtuins as drug targets 57
Selective Non-nucleoside Inhibitors of Human DNA Methyltransferases Active in Cancer Including in Cancer Stem Cells 56
Lysine methyltransferases and their inhibitors 54
Sex-dependent effects of the drugs of abuse amphetamine and the smart drug 3,4-methylenedioxypyrovalerone on fear memory generalization in rats 54
Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells 53
Interactions of polysulfanes with components of red blood cells 53
Sirtuin modulators: where are we now? A review of patents from 2015 to 2019 49
m6A RNA methylation and beyond - the epigenetic machinery and potential treatment options 49
Discovery of phenylselenoether-hydantoin hybrids as ABCB1 efflux pump modulating agents with cytotoxic and antiproliferative actions in resistant T-lymphoma 48
Novel Pyridine-Based Hydroxamates and 2'-Aminoanilides as Histone Deacetylase Inhibitors: Biochemical Profile and Anticancer Activity 48
Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2–EED Interaction 47
Novel benzofuran-chromone and -coumarin derivatives: Synthesis and biological activity in K562 human leukemia cells 45
The innovative potential of statins in cancer: new targets for new therapies 44
Polycomb repressive complex 2 modulation through the development of EZH2–EED interaction inhibitors and EED binders 44
Editorial: chemical innovative approaches in cancer molecular medicine and translational clinical research 36
Metabolite profiling of ascidian Styela plicata using LC–MS with multivariate statistical analysis and their antitumor activity 32
Sirtuins 32
Restoration of WT1/miR-769-5p axis by HDAC1 inhibition promotes MMT reversal in mesenchymal-like mesothelial cells 30
Novel 1,4-Dihydropyridines as Specific Binders and Activators of SIRT3 Impair Cell Viability and Clonogenicity and Downregulate Hypoxia-Induced Targets in Cancer Cells 29
Effects of Structurally Different HDAC Inhibitors against Trypanosoma cruzi, Leishmania, and Schistosoma mansoni 28
Potent and Specific Activators for Mitochondrial Sirtuins Sirt3 and Sirt5 26
Editorial: Multi-target directed ligands for the treatment of cancer 26
Selenium-Containing Agents Acting on Cancer—A New Hope? 26
Chemically diverse S. mansoni HDAC8 inhibitors reduced viability in worm larval and adult stages 25
Heterocycle-containing tranylcypromine derivatives endowed with high anti-LSD1 activity 25
HDAC1/2 control mesothelium/ovarian cancer adhesive interactions impacting on Talin-1-α5β1-integrin-mediated actin cytoskeleton and extracellular matrix protein remodeling 22
Seleno-vs. thioether triazine derivatives in search for new anticancer agents overcoming multidrug resistance in lymphoma 19
First-in-Class Selenium-Containing Potent Serotonin Receptor 5-HT6 Agents with a Beneficial Neuroprotective Profile against Alzheimer's Disease 18
GreenMedChem- the challenge in the next decade toward eco-friendly compounds and processes in drug design 18
HDAC1-3 inhibition increases SARS-CoV-2 replication and productive infection in lung mesothelial and epithelial cells 15
PD-L1 small-molecule modulators: a new hope in epigenetic-based multidrug cancer therapy? 15
Mechanisms of mesothelial cell response to viral infections: HDAC1-3 inhibition blocks poly(I:C)-induced type I interferon response and modulates the mesenchymal/inflammatory phenotype 10
Histone deacetylase 10: A polyamine deacetylase from the crystal structure to the first inhibitors 8
Editorial: Frontiers in Chemistry: rising stars 2022 5
SIRT3 Activation a Promise in Drug Development? New Insights into SIRT3 Biology and Its Implications on the Drug Discovery Process 3
Totale 4.436
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Categoria #
all - tutte 12.560
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 12.560
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2018/2019304 0 0 0 0 0 0 0 0 0 0 161 143
2019/2020884 101 33 7 39 90 118 115 93 98 68 54 68
2020/2021521 59 80 51 32 10 43 6 41 43 78 48 30
2021/2022749 10 46 78 28 94 14 30 87 43 55 150 114
2022/2023854 128 194 49 74 72 112 26 55 59 16 44 25
2023/2024787 26 46 73 48 90 242 58 76 14 84 30 0
Totale 4.436