Catalogo dei prodotti della ricerca

ZWERGEL, CLEMENS
 Distribuzione geografica
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Continente #
NA - Nord America 2.768
EU - Europa 1.362
AS - Asia 490
AF - Africa 24
SA - Sud America 18
Continente sconosciuto - Info sul continente non disponibili 1
Totale 4.663
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Nazione #
US - Stati Uniti d'America 2.738
IT - Italia 728
SG - Singapore 187
SE - Svezia 166
IN - India 124
DE - Germania 108
CN - Cina 101
FI - Finlandia 72
BG - Bulgaria 63
GB - Regno Unito 54
ID - Indonesia 32
ES - Italia 31
UA - Ucraina 28
CA - Canada 25
FR - Francia 22
TG - Togo 21
NL - Olanda 19
RO - Romania 17
TR - Turchia 17
IE - Irlanda 15
AR - Argentina 9
BE - Belgio 9
GR - Grecia 8
CH - Svizzera 7
IR - Iran 7
PK - Pakistan 7
RU - Federazione Russa 6
BR - Brasile 5
MX - Messico 5
HK - Hong Kong 4
CZ - Repubblica Ceca 3
AT - Austria 2
AZ - Azerbaigian 2
KR - Corea 2
PY - Paraguay 2
UZ - Uzbekistan 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AL - Albania 1
AM - Armenia 1
BD - Bangladesh 1
CI - Costa d'Avorio 1
CL - Cile 1
CO - Colombia 1
DZ - Algeria 1
EG - Egitto 1
IL - Israele 1
JP - Giappone 1
KH - Cambogia 1
LT - Lituania 1
LV - Lettonia 1
PL - Polonia 1
Totale 4.663
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Città #
Fairfield 453
Ashburn 370
Rome 324
Woodbridge 187
Houston 179
Chandler 173
Cambridge 142
Seattle 138
Wilmington 136
Singapore 126
Santa Clara 76
Ann Arbor 65
Sofia 63
San Paolo di Civitate 62
Princeton 61
Helsinki 53
Lawrence 52
Dearborn 46
Washington 43
San Diego 39
Millbury 36
New York 36
Plano 36
Jakarta 32
Beijing 25
Andover 22
Lomé 21
Norwalk 19
Boston 18
Milan 18
Dublin 15
Latina 13
Mentana 13
Ottawa 13
Des Moines 12
Istanbul 12
Boardman 11
Florence 11
Toronto 11
Berlin 10
Fiuggi 10
Phoenix 10
Federal 9
Amsterdam 8
Frankfurt am Main 8
Badajoz 7
Nanjing 7
Stockholm 7
Athens 6
Bolzano 6
Colleferro 6
Fasano 6
Zurich 6
Barcelona 5
Brussels 5
Bühl 5
Grafing 5
Jacksonville 5
Los Angeles 5
Monte Cremasco 5
Munich 5
San Mateo 5
Valenza 5
Acquaviva delle Fonti 4
Bilbao 4
Bremen 4
Deurne 4
Eskişehir 4
Falls Church 4
Fremont 4
Hamburg 4
Hefei 4
Hong Kong 4
Lahore 4
London 4
Mannheim 4
Mexico City 4
Nanchang 4
Paris 4
Perugia 4
Pontedera 4
Pozzuoli 4
Prineville 4
Redwood City 4
Salamanca 4
Salerno 4
Shanghai 4
Viterbo 4
Arzano 3
Catania 3
Dallas 3
Fara Gera d'Adda 3
Fuzhou 3
Giugliano in Campania 3
Irpin 3
Kurukshetra 3
Kusterdingen 3
Mashhad 3
Montespertoli 3
Mumbai 3
Totale 3.454
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Nome #
Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells 169
The histone methyltransferase EZH2 as a druggable target in SHH medulloblastoma cancer stem cells 156
Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells 128
The emerging role of epigenetics in human autoimmune disorders 124
1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells 122
HDAC1 inhibition by MS-275 in mesothelial cells limits cellular invasion and promotes MMT reversal 102
Novel quinoline compounds active in cancer cells through coupled DNA methyltransferase inhibition and degradation 102
Novel inhibitors of human histone deacetylases: Design, synthesis and bioactivity of 3-alkenoylcoumarines 100
Discovery of the first human arylsulfatase a reversible inhibitor impairing mouse oocyte fertilization 98
Design of first-in-class dual EZH2/HDAC inhibitor: biochemical activity and biological evaluation in cancer cells 94
Inhibition of PKCθ Improves Dystrophic Heart Phenotype and Function in a Novel Model of DMD Cardiomyopathy 93
MC1568 inhibits HDAC6/8 activity and influenza A virus replication in lung epithelial cells: Role of Hsp90 acetylation 92
Application of small epigenetic modulators in pediatric medulloblastoma 92
Acute and chronic neurobehavioral effects of the designer drug and bath salt constituent 3,4-methylenedioxypyrovalerone in the rat 91
Novel coumarin- and quinolinone-based polycycles as cell division cycle 25-A and -C phosphatases inhibitors induce proliferation arrest and apoptosis in cancer cells 88
Effects of class II-selective histone deacetylase inhibitor on neuromuscular function and disease progression in SOD1-ALS mice 86
Epi-drugs in combination with immunotherapy: a new avenue to improve anticancer efficacy 85
Aurones: Interesting Natural and Synthetic Compounds with Emerging Biological Potential 84
Pyrazole-based inhibitors of enhancer of zeste homologue 2 induce apoptosis and autophagy in cancer cells 84
Amphetamine and the Smart Drug 3,4-Methylenedioxypyrovalerone (MDPV) Induce Generalization of Fear Memory in Rats 83
Histone deacetylase inhibitors restore IL-10 expression in lipopolysaccharide-induced cell inflammation and reduce IL-1β and IL-6 production in breast silicone implant in C57BL/6J wild-type murine model 82
EZH2 inhibitors: a patent review (2014-2016) 82
Amphetamine modulation of long-term object recognition memory in rats: influence of stress 78
A quinoline-based DNA methyltransferase inhibitor as a possible adjuvant in osteosarcoma therapy 75
Six years (2012-2018) of researches on catalytic EZH2 inhibitors: the boom of the 2-pyridone compounds 75
LSD1 inhibitors: a patent review (2010-2015) 75
Trends of LSD1 inhibitors in viral infections 74
Emerging approaches for histone deacetylase inhibitor drug discovery 74
Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells 73
Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells 73
Tranylcypromine-based LSD1 inhibitors: structure-activity relationships, antiproliferative effects in leukemia, and gene target modulation 71
The innovative potential of selenium-containing agents for fighting cancer and viral infections 71
DNA methyltransferases Inhibitors from natural sources 70
Abstract 2946: Effects of two novel quinoline-based non-nucleoside DNA methyltransferase inhibitors against bone sarcomas 70
Detrimental effects of the 'bath salt' methylenedioxypyrovalerone on social play behavior in male rats 70
Sex-dependent effects of the drugs of abuse amphetamine and the smart drug 3,4-methylenedioxypyrovalerone on fear memory generalization in rats 69
One-pot synthesis of benzopyran-4-ones with cancer preventive and therapeutic potential 66
Effect of Class II HDAC inhibition on glutamate transporter expression and survival in SOD1-ALS mice 66
Epigenetic Pharmacology in Regenerative Medicine (Epi-Drugs) 66
Nucleocytoplasmic export of HDAC5 and SIRT2 downregulation: two epigenetic mechanisms by which antidepressants enhance synaptic plasticity markers 63
HDAC1/2 control mesothelium/ovarian cancer adhesive interactions impacting on Talin-1-α5β1-integrin-mediated actin cytoskeleton and extracellular matrix protein remodeling 62
Reactivity of 4-vinyl-2H-1-benzopyran-2-ones in diels-alder cycloaddition reactions: Access to coumarin-based polycycles with Cdc25 phosphatase-inhibiting activity 59
Towards the development of activity-based probes for detection of lysine-specific demethylase-1 activity. 59
Sirtuin modulators: where are we now? A review of patents from 2015 to 2019 59
Sirtuins as drug targets 58
Selective Non-nucleoside Inhibitors of Human DNA Methyltransferases Active in Cancer Including in Cancer Stem Cells 57
Lysine methyltransferases and their inhibitors 57
The innovative potential of statins in cancer: new targets for new therapies 54
Discovery of phenylselenoether-hydantoin hybrids as ABCB1 efflux pump modulating agents with cytotoxic and antiproliferative actions in resistant T-lymphoma 53
Novel Pyridine-Based Hydroxamates and 2'-Aminoanilides as Histone Deacetylase Inhibitors: Biochemical Profile and Anticancer Activity 53
m6A RNA methylation and beyond - the epigenetic machinery and potential treatment options 53
Interactions of polysulfanes with components of red blood cells 53
Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2–EED Interaction 47
Polycomb repressive complex 2 modulation through the development of EZH2–EED interaction inhibitors and EED binders 47
Novel benzofuran-chromone and -coumarin derivatives: Synthesis and biological activity in K562 human leukemia cells 46
First-in-Class Selenium-Containing Potent Serotonin Receptor 5-HT6 Agents with a Beneficial Neuroprotective Profile against Alzheimer's Disease 45
Novel 1,4-Dihydropyridines as Specific Binders and Activators of SIRT3 Impair Cell Viability and Clonogenicity and Downregulate Hypoxia-Induced Targets in Cancer Cells 44
Sirtuins 43
Editorial: chemical innovative approaches in cancer molecular medicine and translational clinical research 42
Potent and Specific Activators for Mitochondrial Sirtuins Sirt3 and Sirt5 41
Restoration of WT1/miR-769-5p axis by HDAC1 inhibition promotes MMT reversal in mesenchymal-like mesothelial cells 40
Effects of structurally different HDAC inhibitors against Trypanosoma cruzi, Leishmania, and Schistosoma mansoni 38
Multi-target directed ligands for the treatment of cancer 36
Selenium-containing agents acting on cancer. A new hope? 36
Heterocycle-containing tranylcypromine derivatives endowed with high anti-LSD1 activity 36
Metabolite profiling of ascidian Styela plicata using LC–MS with multivariate statistical analysis and their antitumor activity 34
Mechanisms of mesothelial cell response to viral infections: HDAC1-3 inhibition blocks poly(I:C)-induced type I interferon response and modulates the mesenchymal/inflammatory phenotype 32
Chemically diverse S. mansoni HDAC8 inhibitors reduced viability in worm larval and adult stages 29
GreenMedChem- the challenge in the next decade toward eco-friendly compounds and processes in drug design 27
SIRT3 Activation a Promise in Drug Development? New Insights into SIRT3 Biology and Its Implications on the Drug Discovery Process 25
Seleno-vs. thioether triazine derivatives in search for new anticancer agents overcoming multidrug resistance in lymphoma 23
HDAC1-3 inhibition increases SARS-CoV-2 replication and productive infection in lung mesothelial and epithelial cells 18
Histone deacetylase 10: A polyamine deacetylase from the crystal structure to the first inhibitors 18
Unlocking the potential of higher-molecular-weight 5-HT7R ligands. Synthesis, affinity, and ADMET examination 17
Heterocycles-containing HDAC inhibitors active in cancer. An overview of the last fifteen years 16
PD-L1 small-molecule modulators: a new hope in epigenetic-based multidrug cancer therapy? 16
HDAC3 genetic and pharmacologic inhibition radiosensitizes fusion positive rhabdomyosarcoma by promoting DNA double-strand breaks 16
Selenium-containing compounds. A new hope for innovative treatments in Alzheimer’s disease and Parkinson’s disease 14
Editorial: Frontiers in Chemistry: rising stars 2022 9
Totale 5.028
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Categoria #
all - tutte 17.580
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 17.580
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020614 0 0 0 0 0 118 115 93 98 68 54 68
2020/2021521 59 80 51 32 10 43 6 41 43 78 48 30
2021/2022749 10 46 78 28 94 14 30 87 43 55 150 114
2022/2023854 128 194 49 74 72 112 26 55 59 16 44 25
2023/2024833 26 46 73 48 90 242 58 76 14 84 47 29
2024/2025546 53 50 95 135 123 90 0 0 0 0 0 0
Totale 5.028