Polyamine deacetylase activity was discovered more than 40 years ago, but the responsible histone deacetylase 10 (HDAC10) was described only recently. HDAC10 is a class IIb HDAC, as is its closest relative, the a-tubulin deacetylase HDAC6. HDAC10 has attracted attention over the last 2 years due to its role in diseases, especially cancer. This review summarises chemical and structural biology approaches to the study of HDAC10. Light will be shed on recent advances in understanding the complex structural biology of HDAC10 and the discovery of the first highly selective HDAC10 inhibitors.

Histone deacetylase 10: A polyamine deacetylase from the crystal structure to the first inhibitors / Lambona, Chiara; Zwergel, Clemens; Fioravanti, Rossella; Valente, Sergio; Mai, Antonello. - In: CURRENT OPINION IN STRUCTURAL BIOLOGY. - ISSN 0959-440X. - 82:(2023). [10.1016/j.sbi.2023.102668]

Histone deacetylase 10: A polyamine deacetylase from the crystal structure to the first inhibitors

Lambona, Chiara;Zwergel, Clemens;Fioravanti, Rossella
;
Valente, Sergio;Mai, Antonello
2023

Abstract

Polyamine deacetylase activity was discovered more than 40 years ago, but the responsible histone deacetylase 10 (HDAC10) was described only recently. HDAC10 is a class IIb HDAC, as is its closest relative, the a-tubulin deacetylase HDAC6. HDAC10 has attracted attention over the last 2 years due to its role in diseases, especially cancer. This review summarises chemical and structural biology approaches to the study of HDAC10. Light will be shed on recent advances in understanding the complex structural biology of HDAC10 and the discovery of the first highly selective HDAC10 inhibitors.
2023
HDAC10, Polyamine deacetylase, Crystallography, HDAC10 sub- strates, HDAC10 inhibitors
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Histone deacetylase 10: A polyamine deacetylase from the crystal structure to the first inhibitors / Lambona, Chiara; Zwergel, Clemens; Fioravanti, Rossella; Valente, Sergio; Mai, Antonello. - In: CURRENT OPINION IN STRUCTURAL BIOLOGY. - ISSN 0959-440X. - 82:(2023). [10.1016/j.sbi.2023.102668]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1685964
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