m6A is emerging as one of the most important RNA modifications because of its involvement in pathological and physiological events. Here, we provide an overview of this epitranscriptomic modification, beginning with a description of the molecular players involved and continuing with a focus on the role of m6A in the maintenance of stemness, induction of the epithelial to mesenchymal transition (EMT), and tumor progression. Finally, we discuss the state of the art regarding the design and validation of inhibitors of m6A writers or erasers to provide a background for future investigations and for the development of specific therapeutics.

m6A RNA methylation and beyond - the epigenetic machinery and potential treatment options / Garbo, Sabrina; Zwergel, Clemens; Battistelli, Cecilia. - In: DRUG DISCOVERY TODAY. - ISSN 1359-6446. - 26:11(2021), pp. 2559-2574. [10.1016/j.drudis.2021.06.004]

m6A RNA methylation and beyond - the epigenetic machinery and potential treatment options

Garbo, Sabrina;Zwergel, Clemens
;
Battistelli, Cecilia
2021

Abstract

m6A is emerging as one of the most important RNA modifications because of its involvement in pathological and physiological events. Here, we provide an overview of this epitranscriptomic modification, beginning with a description of the molecular players involved and continuing with a focus on the role of m6A in the maintenance of stemness, induction of the epithelial to mesenchymal transition (EMT), and tumor progression. Finally, we discuss the state of the art regarding the design and validation of inhibitors of m6A writers or erasers to provide a background for future investigations and for the development of specific therapeutics.
2021
epitranscriptomics; m6A; METTL3; RNA; cancer
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
m6A RNA methylation and beyond - the epigenetic machinery and potential treatment options / Garbo, Sabrina; Zwergel, Clemens; Battistelli, Cecilia. - In: DRUG DISCOVERY TODAY. - ISSN 1359-6446. - 26:11(2021), pp. 2559-2574. [10.1016/j.drudis.2021.06.004]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1552435
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