Catalogo dei prodotti della ricerca

VALENTE, Sergio
 Distribuzione geografica
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Continente #
NA - Nord America 6.636
EU - Europa 2.332
AS - Asia 800
AF - Africa 38
SA - Sud America 36
OC - Oceania 5
Continente sconosciuto - Info sul continente non disponibili 1
Totale 9.848
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Nazione #
US - Stati Uniti d'America 6.590
IT - Italia 1.116
SE - Svezia 367
IN - India 278
SG - Singapore 274
CN - Cina 200
DE - Germania 170
FI - Finlandia 155
UA - Ucraina 148
GB - Regno Unito 125
BG - Bulgaria 64
CA - Canada 42
IE - Irlanda 42
AR - Argentina 32
TG - Togo 31
RO - Romania 28
ES - Italia 27
FR - Francia 22
NL - Olanda 21
BE - Belgio 17
TR - Turchia 13
RU - Federazione Russa 11
HK - Hong Kong 9
IR - Iran 8
AT - Austria 6
CH - Svizzera 6
MX - Messico 4
AU - Australia 3
CL - Cile 3
PK - Pakistan 3
CI - Costa d'Avorio 2
HU - Ungheria 2
JP - Giappone 2
KR - Corea 2
NZ - Nuova Zelanda 2
PT - Portogallo 2
SC - Seychelles 2
UZ - Uzbekistan 2
A2 - ???statistics.table.value.countryCode.A2??? 1
AE - Emirati Arabi Uniti 1
AL - Albania 1
AM - Armenia 1
AZ - Azerbaigian 1
BD - Bangladesh 1
CO - Colombia 1
CZ - Repubblica Ceca 1
DZ - Algeria 1
EG - Egitto 1
IL - Israele 1
KG - Kirghizistan 1
KH - Cambogia 1
MY - Malesia 1
PL - Polonia 1
SA - Arabia Saudita 1
ZA - Sudafrica 1
Totale 9.848
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Città #
Fairfield 1.132
Ashburn 859
Woodbridge 533
Rome 462
Chandler 404
Houston 404
Seattle 387
Cambridge 364
Wilmington 360
Ann Arbor 210
Singapore 165
Princeton 156
San Paolo di Civitate 139
Lawrence 126
Dearborn 122
Washington 112
Plano 111
Beijing 82
Millbury 82
San Diego 80
New York 67
Sofia 64
Helsinki 60
Boston 59
Jacksonville 43
Dublin 41
Andover 34
Des Moines 34
Boardman 32
Federal 32
Lomé 31
Milan 30
Fasano 28
Norwalk 27
Florence 26
Toronto 25
Nanjing 18
Berlin 16
Falls Church 16
Kunming 15
Ottawa 15
Bremen 14
Fremont 14
Hefei 13
Mentana 13
Phoenix 13
Amsterdam 11
Brussels 11
Monte Cremasco 11
Frankfurt am Main 10
Santa Clara 10
Bühl 9
London 9
Los Angeles 9
Naples 9
Barcelona 8
Cagliari 8
Fiuggi 8
Hong Kong 8
Nanchang 8
Istanbul 7
Lappeenranta 7
Mannheim 7
Palermo 7
Redwood City 7
Caserta 6
Deurne 6
Grafing 6
Laurel 6
San Mateo 6
Acquaviva delle Fonti 5
Colleferro 5
Fuzhou 5
Jinan 5
Lanuvio 5
Munich 5
Ningbo 5
Pozzuoli 5
Valenza 5
Atrani 4
Auburn Hills 4
Brugine 4
Eskişehir 4
Guangzhou 4
Hamburg 4
Indiana 4
Kilburn 4
Las Vegas 4
Latina 4
Novara 4
Perugia 4
Pessac 4
Pontedera 4
Pune 4
Redmond 4
Salamanca 4
Salerno 4
Turin 4
Vienna 4
Viterbo 4
Totale 7.393
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Nome #
Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells 166
Dissecting the role of novel EZH2 inhibitors in primary glioblastoma cell cultures: effects on proliferation, epithelial-mesenchymal transition, migration, and on the pro-inflammatory phenotype 151
The histone methyltransferase EZH2 as a druggable target in SHH medulloblastoma cancer stem cells 150
Study of 1,4-Dihydropyridine Structural Scaffold: Discovery of Novel Sirtuin Activators and Inhibitors 138
Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells 125
1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells 121
1,3,4-Oxadiazole-Containing Histone Deacetylase Inhibitors: Anticancer Activities in Cancer Cells 109
Synthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: A novel class of irreversible inhibitors of histone demethylase KDM1A 104
Novel inhibitors of human histone deacetylases: Design, synthesis and bioactivity of 3-alkenoylcoumarines 100
Pure enantiomers of benzoylamino-tranylcypromine: LSD1 inhibition, gene modulation in human leukemia cells and effects on clonogenic potential of murine promyelocytic blasts 100
Novel quinoline compounds active in cancer cells through coupled DNA methyltransferase inhibition and degradation 100
HDAC1 inhibition by MS-275 in mesothelial cells limits cellular invasion and promotes MMT reversal 99
Antimalarial and Antileishmanial Activities of Aroyl-pyrrolyl-hydroxy-amides, a New Class of Histone Deacetylase Inhibitors 98
New pyrrole-based histone deacetylase inhibitors: Binding mode, enzyme- and cell-based investigations 98
3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamides as a New Class of Synthetic Histone Deacetylase Inhibitors. 2. Effect of Pyrrole-C2 and/or -C4 Substitutions on Biological Activity 96
Design of first-in-class dual EZH2/HDAC inhibitor: biochemical activity and biological evaluation in cancer cells 94
Discovery of the first human arylsulfatase a reversible inhibitor impairing mouse oocyte fertilization 94
Specific Activity of Class II Histone Deacetylases in Human Breast Cancer Cells 92
Novel pyrrole-containing histone deacetylase inhibitors endowed with cytodifferentiation activity 92
Application of small epigenetic modulators in pediatric medulloblastoma 91
Inhibition of PKCθ Improves Dystrophic Heart Phenotype and Function in a Novel Model of DMD Cardiomyopathy 89
Sirtuin modulators: an updated patent review (2012 - 2014) 88
MC1568 inhibits HDAC6/8 activity and influenza A virus replication in lung epithelial cells: Role of Hsp90 acetylation 88
Developing novel non-hydroxamate histone deacetylase inhibitors: the chelidamic warhead. 87
3-D QSAR Studies on Histone Deacetylase Inhibitors. A GOLPE/GRID Approach on Different Series of Compounds. 87
Pure diastereomers of a tranylcypromine-based LSD1 inhibitor: enzyme selectivity and in-cell studies 87
Nitric oxide determines mesodermic differentiation of mouse embryonic stem cells by activating class IIa histone deacetylases: potential therapeutic implications in a mouse model of hindlimb ischemia 85
Effects of class II-selective histone deacetylase inhibitor on neuromuscular function and disease progression in SOD1-ALS mice 84
Identification of novel quinazoline derivatives as potent antiplasmodial agents 84
Pyrrole- and indole-containing tranylcypromine derivatives as novel lysine-specific demethylase 1 inhibitors active on cancer cells. 84
New Aroyl-Pyrrolyl-Hydroxy-Amides APHAs: Class I and II Histone Deacetylase Inhibiting Activity and Binding Mode Analysis through Molecular Docking Experiments 83
Application of 3 μm particle-based amylose-derived chiral stationary phases for the enantioseparation of potential histone deacetylase inhibitors. 83
Novel Cinnamyl Hydroxyamides and 2-Aminoanilides as Histone Deacetylase Inhibitors: Apoptotic Induction and Cytodifferentiation Activity 83
Aurones: Interesting Natural and Synthetic Compounds with Emerging Biological Potential 83
Novel coumarin- and quinolinone-based polycycles as cell division cycle 25-A and -C phosphatases inhibitors induce proliferation arrest and apoptosis in cancer cells 82
Cytoplasmic HDAC4 regulates the membrane repair mechanism in Duchenne muscular dystrophy 81
Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities 80
Epi-drugs in combination with immunotherapy: a new avenue to improve anticancer efficacy 80
Pyrazole-based inhibitors of enhancer of zeste homologue 2 induce apoptosis and autophagy in cancer cells 79
Discovery of a novel inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) as orally active antitumor agent 79
Interplay among nucleosomal DNA, histone tails, and corepressor CoREST underlies LSD1-mediated H3 demethylation 79
Pyrrole-Based Hydroxamates and 2-Aminoanilides: Histone Deacetylase Inhibition and Cellular Activities 79
The Polycomb group (PcG) protein EZH2 supports the survival of PAX3-FOXO1 alveolar rhabdomyosarcoma by repressing FBXO32 (Atrogin1/MAFbx) 79
3-(1H-Pyrrol-2-yl)-2-oxazolidinones as novel monoamine oxidase type A inhibitors. 78
A Nitric Oxide-dependent crosstalk between class I and III Histone Deacetylases accelerates skin repair. 78
EZH2 inhibitors: a patent review (2014-2016) 78
Discovery of inhibitors for the ether lipid-generating enzyme AGPS as anti-cancer agents 78
Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC-MEF2 complexes. 77
Histone Deacetylation in Epigenetics: An Attractive Target for Anticancer Therapy 77
Histone deacetylase inhibitors restore IL-10 expression in lipopolysaccharide-induced cell inflammation and reduce IL-1β and IL-6 production in breast silicone implant in C57BL/6J wild-type murine model 77
Aroyl-pyrrolyl hydroxyamides: Influence of pyrrole C4-phenylacetyl substitution on histone deacetylase inhibition 77
Targeting the anti-apoptotic Bcl-2 family proteins: Machine learning virtual screening and biological evaluation of new small molecules 77
Histone deacetylase inhibitors and neurodegenerative disorders: Holding the promise 76
PRMT1 arginine methyltransferase accumulates in cytoplasmic bodies that respond to selective inhibition and DNA damage 75
Synthesis and biological validation of novel synthetic histone/protein methyltransferase inhibitors 74
Detrimental effect of class-selective histone deacetylase inhibitors during tissue regeneration following hindlimb ischemia 73
Six years (2012-2018) of researches on catalytic EZH2 inhibitors: the boom of the 2-pyridone compounds 73
Altered modulation of lamin A/C-HDAC2 interaction and p21 expression during oxidative stress response in HGPS 73
Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells 73
Identification of PR-SET7 and EZH2 selective inhibitors inducing cell death in human leukemia U937 cells 73
Emerging approaches for histone deacetylase inhibitor drug discovery 72
Role of SIRT3 in Microgravity Response: A New Player in Muscle Tissue Recovery 71
A quinoline-based DNA methyltransferase inhibitor as a possible adjuvant in osteosarcoma therapy 71
Abstract 2946: Effects of two novel quinoline-based non-nucleoside DNA methyltransferase inhibitors against bone sarcomas 70
TNF/p38α/polycomb signaling to Pax7 locus in satellite cells links inflammation to the epigenetic control of muscle regeneration 70
Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors 70
LSD1 inhibitors: a patent review (2010-2015) 70
New insights on the mechanism of quinoline-based DNA methyltransferase inhibitors 70
Trends of LSD1 inhibitors in viral infections 69
Pharmacological inhibition of EZH2 as a promising differentiation therapy in embryonal RMS 67
DNA methyltransferases Inhibitors from natural sources 67
Molecular mechanisms and new therapeutic targets in epithelial to mesenchymal transition (EMT) and fibrosis 67
Effect of Class II HDAC inhibition on glutamate transporter expression and survival in SOD1-ALS mice 66
Tranylcypromine-based LSD1 inhibitors: structure-activity relationships, antiproliferative effects in leukemia, and gene target modulation 66
Nitric oxide modulates chromatin folding in human endothelial cells via protein phosphatase 2A activation and class II histone deacetylases nuclear shuttling 65
Amino acid starvation induces reactivation of silenced transgenes and latent HIV-1 provirus via down-regulation of histone deacetylase 4 (HDAC4) 65
Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases LSD1 and LSD2 64
A novel coumarin-quinone derivative SV37 inhibits CDC25 phosphatases, impairs proliferation, and induces cell death. 64
Synthesis and biochemical evaluation of (R)-5-acyloxymethyl- and (S)-5-acylaminomethyl-3-(1H-pyrrol-1-yl)-2-oxazolidinones as new anti-monoamine oxidase (anti-MAO) agents. 64
Histone post-translational modifications by HPLC-ESI-MS after HT29 cell treatment with HDAC inhibitors 63
Chalcone-Coumarin derivatives as potential anti-cancer drugs: an in vitro and in vivo investigation 63
Combined HAT/EZH2 modulation leads to cancer-selective cell death 63
Chronic stress and antidepressant induced changes in Hdac5 and Sirt2 affect synaptic plasticity 63
Novel Reversible Monoamine Oxidase A Inhibitors: Highly Potent and Selective 3-(1H-Pyrrol-3-yl)-2-oxazolidinones 63
Shock and kill" effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence 62
Coumarin polysulfides inhibit cell growth and induce apoptosis in HCT116 colon cancer cells 61
Oxidative stress and epigenetic regulation in ageing and age-related diseases 61
Properly substituted cyclic Bis-(2-bromobenzylidene) compounds behaved as dual p300/CARM1 Inhibitors and Induced apoptosis in cancer cells 61
HDAC-class II specific inhibition involves HDAC proteasome-dependent degradation mediated by RANBP2 60
Nucleocytoplasmic export of HDAC5 and SIRT2 downregulation: two epigenetic mechanisms by which antidepressants enhance synaptic plasticity markers 60
Epigenetic Pharmacology in Regenerative Medicine (Epi-Drugs) 60
3-(4-Aroyl-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 3. Discovery of novel lead compounds through structure-based drug design and docking studies. 60
Determinants of epigenetic resistance to HDAC inhibitors in dystrophic fibro-adipogenic progenitors 60
Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells 59
Novel 3,5-bis(bromohydroxybenzylidene)piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors: Enzyme selectivity and cellular activity 59
Reactivity of 4-vinyl-2H-1-benzopyran-2-ones in diels-alder cycloaddition reactions: Access to coumarin-based polycycles with Cdc25 phosphatase-inhibiting activity 59
Reversible acetylation regulates vascular endothelial growth factor receptor-2 activity 59
Class II HDAC Inhibition Hampers Hepatic Stellate Cell Activation by Induction of MicroRNA-29 59
CDK9 as a valuable target in cancer: from natural compounds inhibitors to current treatment in pediatric soft tissue sarcomas 59
Context-Selective Death of Acute Myeloid Leukemia Cells Triggered by the Novel Hybrid Retinoid-HDAC Inhibitor MC2392. 58
Totale 7.978
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Categoria #
all - tutte 31.380
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 100
selected - selezionate 0
volume - volumi 0
Totale 31.480
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.841 0 0 0 88 206 322 313 245 245 169 130 123
2020/2021931 112 128 82 72 23 54 45 63 90 132 89 41
2021/20221.733 15 132 179 116 188 36 53 196 106 118 298 296
2022/20231.808 307 412 95 163 159 205 47 124 137 58 71 30
2023/20241.523 57 107 160 85 164 451 64 119 23 127 102 64
2024/2025339 119 61 123 36 0 0 0 0 0 0 0 0
Totale 10.357