Background: No information is available about the effect of class-selective histone deacetylase inhibitors (DIs) following hindlimb ischemia. Results: Class I and class IIa DIs prevent/delay ischemic muscle reconstruction at different stages. Conclusion: Evidence is provided about a detrimental effect of DIs during normal muscle regeneration. Significance: The therapeutic relevance of class-selective DIs in hindlimb ischemia may be limited by adverse effects. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
Detrimental effect of class-selective histone deacetylase inhibitors during tissue regeneration following hindlimb ischemia / F., Spallotta; Silvia, Tardivo; S., Nanni; J. D., Rosati; S., Straino; Mai, Antonello; M., Vecellio; Valente, Sergio; M. C., Capogrossi; A., Farsetti; Martone, Julie; Bozzoni, Irene; A., Pontecorvi; C., Gaetano; C., Colussi. - In: THE JOURNAL OF BIOLOGICAL CHEMISTRY. - ISSN 0021-9258. - 288:32(2013), pp. 22915-22929. [10.1074/jbc.m113.484337]
Detrimental effect of class-selective histone deacetylase inhibitors during tissue regeneration following hindlimb ischemia
F. Spallotta;MAI, Antonello;VALENTE, Sergio;MARTONE, Julie;BOZZONI, Irene;
2013
Abstract
Background: No information is available about the effect of class-selective histone deacetylase inhibitors (DIs) following hindlimb ischemia. Results: Class I and class IIa DIs prevent/delay ischemic muscle reconstruction at different stages. Conclusion: Evidence is provided about a detrimental effect of DIs during normal muscle regeneration. Significance: The therapeutic relevance of class-selective DIs in hindlimb ischemia may be limited by adverse effects. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
