Background: No information is available about the effect of class-selective histone deacetylase inhibitors (DIs) following hindlimb ischemia. Results: Class I and class IIa DIs prevent/delay ischemic muscle reconstruction at different stages. Conclusion: Evidence is provided about a detrimental effect of DIs during normal muscle regeneration. Significance: The therapeutic relevance of class-selective DIs in hindlimb ischemia may be limited by adverse effects. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
Detrimental effect of class-selective histone deacetylase inhibitors during tissue regeneration following hindlimb ischemia / Spallotta, F.; Silvia, Tardivo; Nanni, S.; Rosati, J. D.; Straino, S.; Mai, Antonello; Vecellio, M.; Valente, Sergio; Capogrossi, M. C.; Farsetti, A.; Martone, Julie; Bozzoni, Irene; Pontecorvi, A.; Gaetano, C.; Colussi, C.. - In: THE JOURNAL OF BIOLOGICAL CHEMISTRY. - ISSN 0021-9258. - 288:32(2013), pp. 22915-22929. [10.1074/jbc.m113.484337]
Detrimental effect of class-selective histone deacetylase inhibitors during tissue regeneration following hindlimb ischemia
F. SpallottaPrimo
;MAI, Antonello;VALENTE, Sergio;MARTONE, Julie;BOZZONI, Irene;
2013
Abstract
Background: No information is available about the effect of class-selective histone deacetylase inhibitors (DIs) following hindlimb ischemia. Results: Class I and class IIa DIs prevent/delay ischemic muscle reconstruction at different stages. Conclusion: Evidence is provided about a detrimental effect of DIs during normal muscle regeneration. Significance: The therapeutic relevance of class-selective DIs in hindlimb ischemia may be limited by adverse effects. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.| File | Dimensione | Formato | |
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