Background: No information is available about the effect of class-selective histone deacetylase inhibitors (DIs) following hindlimb ischemia. Results: Class I and class IIa DIs prevent/delay ischemic muscle reconstruction at different stages. Conclusion: Evidence is provided about a detrimental effect of DIs during normal muscle regeneration. Significance: The therapeutic relevance of class-selective DIs in hindlimb ischemia may be limited by adverse effects. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
Detrimental effect of class-selective histone deacetylase inhibitors during tissue regeneration following hindlimb ischemia / Spallotta, F., Silvia, T., Nanni, S., Rosati, J.D., Straino, S., Mai, A., Vecellio, M., Valente, S., Capogrossi, M.C., Farsetti, A., Martone, J., Bozzoni, I., Pontecorvi, A., Gaetano, C., Colussi, C.. - In: THE JOURNAL OF BIOLOGICAL CHEMISTRY. - ISSN 0021-9258. - 288:32(2013), pp. 22915-22929. [10.1074/jbc.m113.484337]
Detrimental effect of class-selective histone deacetylase inhibitors during tissue regeneration following hindlimb ischemia
F. SpallottaPrimo
;MAI, Antonello;VALENTE, Sergio;MARTONE, Julie;BOZZONI, Irene;
2013
Abstract
Background: No information is available about the effect of class-selective histone deacetylase inhibitors (DIs) following hindlimb ischemia. Results: Class I and class IIa DIs prevent/delay ischemic muscle reconstruction at different stages. Conclusion: Evidence is provided about a detrimental effect of DIs during normal muscle regeneration. Significance: The therapeutic relevance of class-selective DIs in hindlimb ischemia may be limited by adverse effects. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.| File | Dimensione | Formato | |
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