Vinca sardoa (Stearn) Pignatti, known as Sardinian periwinkle, is widely diffused in Sardinia (Italy). This species contains indole alkaloids, which are known to have a great variety of biological activities. This study investigated the antileukemic activity against a B lymphoblast cell line (SUP-B15) of V. sardoa alkaloid-rich extracts obtained from plants grown in Italy, in Iglesias (Sardinia) and Rome (Latium). All the extracts showed a good capacity to induce reductions in cell proliferation of up to 50% at the tested concentrations (1–15 g/mL). Moreover, none of the extracts showed cytotoxicity on normal cells at all the studied concentrations.
Phytochemical analysis and In vitro antileukemic activity of alkaloid-enriched extracts from Vinca sardoa (Stearn) Pignatti / DE VITA, D., Frezza, C., Sciubba, F., Toniolo, C., Badiali, C., Petrucci, R., Bortolami, M., DI MATTEO, P., Rocco, D., Stringaro, A., Colone, M., Maxia, A., Petrucci, M.T., Serafini, M., Foddai, S.. - In: MOLECULES. - ISSN 1420-3049. - 28:15(2023), pp. 1-10. [10.3390/molecules28155639]
Phytochemical analysis and In vitro antileukemic activity of alkaloid-enriched extracts from Vinca sardoa (Stearn) Pignatti
Daniela De Vita
;Claudio Frezza;Fabio Sciubba;Chiara Toniolo;Camilla Badiali;Rita Petrucci;Martina Bortolami;Paola Di Matteo;Daniele Rocco;Maria Teresa Petrucci;Mauro Serafini;Sebastiano Foddai
2023
Abstract
Vinca sardoa (Stearn) Pignatti, known as Sardinian periwinkle, is widely diffused in Sardinia (Italy). This species contains indole alkaloids, which are known to have a great variety of biological activities. This study investigated the antileukemic activity against a B lymphoblast cell line (SUP-B15) of V. sardoa alkaloid-rich extracts obtained from plants grown in Italy, in Iglesias (Sardinia) and Rome (Latium). All the extracts showed a good capacity to induce reductions in cell proliferation of up to 50% at the tested concentrations (1–15 g/mL). Moreover, none of the extracts showed cytotoxicity on normal cells at all the studied concentrations.| File | Dimensione | Formato | |
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