Catalogo dei prodotti della ricerca

MAI, Antonello
 Distribuzione geografica
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Continente #
NA - Nord America 16.385
EU - Europa 6.195
AS - Asia 2.552
SA - Sud America 123
AF - Africa 112
Continente sconosciuto - Info sul continente non disponibili 8
OC - Oceania 5
Totale 25.380
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Nazione #
US - Stati Uniti d'America 16.241
IT - Italia 2.711
SE - Svezia 958
SG - Singapore 941
IN - India 774
CN - Cina 610
UA - Ucraina 576
FI - Finlandia 429
GB - Regno Unito 428
DE - Germania 411
BG - Bulgaria 149
CA - Canada 131
RO - Romania 106
AR - Argentina 102
ID - Indonesia 97
IE - Irlanda 97
TG - Togo 89
BE - Belgio 67
FR - Francia 64
NL - Olanda 51
ES - Italia 42
HK - Hong Kong 29
CH - Svizzera 23
AT - Austria 22
TR - Turchia 21
IR - Iran 18
RU - Federazione Russa 16
GR - Grecia 15
MX - Messico 13
IL - Israele 11
KR - Corea 10
CL - Cile 9
CZ - Repubblica Ceca 7
BR - Brasile 6
EU - Europa 6
JP - Giappone 6
PK - Pakistan 6
ZA - Sudafrica 6
BD - Bangladesh 5
ET - Etiopia 5
PL - Polonia 5
AU - Australia 4
MY - Malesia 4
NO - Norvegia 4
AM - Armenia 3
AZ - Azerbaigian 3
CO - Colombia 3
DK - Danimarca 3
DZ - Algeria 3
EG - Egitto 3
PT - Portogallo 3
PY - Paraguay 3
SC - Seychelles 3
A2 - ???statistics.table.value.countryCode.A2??? 2
AE - Emirati Arabi Uniti 2
CI - Costa d'Avorio 2
HU - Ungheria 2
KG - Kirghizistan 2
LU - Lussemburgo 2
SA - Arabia Saudita 2
UZ - Uzbekistan 2
AL - Albania 1
JO - Giordania 1
KH - Cambogia 1
LK - Sri Lanka 1
LT - Lituania 1
LV - Lettonia 1
NZ - Nuova Zelanda 1
PH - Filippine 1
SK - Slovacchia (Repubblica Slovacca) 1
TH - Thailandia 1
TN - Tunisia 1
VN - Vietnam 1
Totale 25.380
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Città #
Fairfield 2.780
Ashburn 1.659
Woodbridge 1.309
Chandler 1.044
Rome 1.035
Houston 1.033
Seattle 962
Wilmington 889
Cambridge 866
Singapore 628
Ann Arbor 511
Princeton 422
San Paolo di Civitate 393
Dearborn 338
Lawrence 317
Plano 310
Beijing 227
Millbury 211
San Diego 206
New York 198
Jacksonville 176
Santa Clara 170
Boston 168
Sofia 148
Helsinki 143
Washington 122
Andover 115
Fasano 104
Federal 102
Jakarta 96
Dublin 95
Boardman 93
Lomé 89
Toronto 79
Des Moines 73
Norwalk 67
Milan 66
Florence 47
Grafing 45
Bremen 43
Monte Cremasco 43
Nanjing 42
Ottawa 42
Kunming 38
Berlin 36
Falls Church 35
Stockholm 35
Hefei 33
Brussels 32
Fremont 31
Los Angeles 30
Bühl 29
London 28
Mannheim 27
Phoenix 27
Frankfurt am Main 25
Jinan 22
Amsterdam 20
Lappeenranta 19
Nanchang 18
Vienna 18
Caserta 17
Naples 17
Philadelphia 17
Deurne 16
Palermo 16
Dallas 15
San Mateo 15
Shanghai 15
Auburn Hills 14
Salerno 14
Barcelona 13
Fuzhou 13
Guangzhou 13
Istanbul 13
Mentana 13
Munich 13
Paris 13
Hong Kong 12
Laurel 12
Pune 12
Buffalo 11
Leuven 11
Napoli 11
Pessac 11
Redwood City 11
Bologna 10
Athens 9
Bari 9
Catania 9
Mexico City 9
Perugia 9
Redmond 9
Shenyang 9
Wuhan 9
Brescia 8
Falkenstein 8
Fiuggi 8
Frattamaggiore 8
Indiana 8
Totale 18.469
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Nome #
Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells 168
The histone methyltransferase EZH2 as a druggable target in SHH medulloblastoma cancer stem cells 156
Modulatori epigenetici: una via alternativa nella terapia delle infezioni fungine sistemiche 155
Dissecting the role of novel EZH2 inhibitors in primary glioblastoma cell cultures: effects on proliferation, epithelial-mesenchymal transition, migration, and on the pro-inflammatory phenotype 154
Study of 1,4-Dihydropyridine Structural Scaffold: Discovery of Novel Sirtuin Activators and Inhibitors 138
Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells 126
The emerging role of epigenetics in human autoimmune disorders 124
1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells 121
Disruptor of telomeric silencing 1-like (DOT1L): disclosing a new class of non-nucleoside inhibitors by means of ligand-based and structure-based approaches 113
2-(Alkyl/aryl)amino-6-benzylpyrimidin-4(3H)-ones as inhibitors of wild-type and mutant HIV-1: enantioselectivity studies. 112
SIRT5 regulation of ammonia-induced autophagy and mitophagy 111
Identification of Small-Molecule Inhibitors of the XendoU Endoribonucleases Family 110
1,3,4-Oxadiazole-Containing Histone Deacetylase Inhibitors: Anticancer Activities in Cancer Cells 110
RIP1-HAT1-SirT complex identification and targeting in treatment and prevention of cancer 110
The International Human Epigenome Consortium: a blueprint for scientific collaboration and discovery 110
Identification of small molecules inhibitors of GCN5 histone acetyltransferase activity 109
Essential oil extraction, chemical analysis and anti-candida activity of calamintha nepeta (L.) Savi subsp. glandulosa (Req.) ball-new approaches 109
Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma. 105
Effect of α-methoxy substitution on the anti-HIV activity of dihydropyrimidin-4(3 H)-ones 105
Synthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: A novel class of irreversible inhibitors of histone demethylase KDM1A 104
New pyrrole-based histone deacetylase inhibitors: Binding mode, enzyme- and cell-based investigations 102
Modulatori epigenetici: potenziali target per strategie terapeutiche innovative 102
HDAC1 inhibition by MS-275 in mesothelial cells limits cellular invasion and promotes MMT reversal 102
Pure enantiomers of benzoylamino-tranylcypromine: LSD1 inhibition, gene modulation in human leukemia cells and effects on clonogenic potential of murine promyelocytic blasts 102
Downregulation of miR-326 and its host gene β-arrestin1 induces pro survival activity of E2F1 and promotes medulloblastoma growth 102
Novel quinoline compounds active in cancer cells through coupled DNA methyltransferase inhibition and degradation 101
Novel inhibitors of human histone deacetylases: Design, synthesis and bioactivity of 3-alkenoylcoumarines 100
The histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces cardiac arrhythmias in dystrophic mice 100
Antimalarial and Antileishmanial Activities of Aroyl-pyrrolyl-hydroxy-amides, a New Class of Histone Deacetylase Inhibitors 98
Epi-drugs to fight cancer: From chemistry to cancer treatment, the road ahead 97
3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamides as a New Class of Synthetic Histone Deacetylase Inhibitors. 2. Effect of Pyrrole-C2 and/or -C4 Substitutions on Biological Activity 97
A new facile and expeditious synthesis of N-hydroxy-N\'-phenyloctanediamide, a potent inducer of terminal cytodifferentiation 96
Discovery of the first human arylsulfatase a reversible inhibitor impairing mouse oocyte fertilization 95
5-Alkyl-6-benzyl-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones, a series of anti-HIV-1 agents of the dihydro-alkoxy-benzyl-oxopyrimidine family with peculiar structure-activity relationship profile. 94
Design of first-in-class dual EZH2/HDAC inhibitor: biochemical activity and biological evaluation in cancer cells 94
Novel pyrrole-containing histone deacetylase inhibitors endowed with cytodifferentiation activity 93
Histone Deacetylase Inhibitors: Structure-Based Modeling and Isoform-Selectivity Prediction 93
Specific Activity of Class II Histone Deacetylases in Human Breast Cancer Cells 92
Application of small epigenetic modulators in pediatric medulloblastoma 92
(((thienylcarbonyl)alkyl)oxy)phenyl)- and (((pyrrylcarbonyl)alkyl)oxy)phenyl)oxazoline derivatives with potent and selective antihuman rhinovirus activity 92
The therapeutic uses of chromatin-modifying agents 91
Design, Synthesis and Biological Evaluation of Carboxy Analogues of Arginine Methyltransferase Inhibitor 1 (AMI-1) 91
Acute and chronic neurobehavioral effects of the designer drug and bath salt constituent 3,4-methylenedioxypyrovalerone in the rat 91
MC1568 inhibits HDAC6/8 activity and influenza A virus replication in lung epithelial cells: Role of Hsp90 acetylation 90
Development of 1,2,4-oxadiazoles as potent and selective inhibitors of the human deacetylase sirtuin 2: structure-activity relationship, X-ray crystal structure, and anticancer activity 90
Chiral HPLC separation and absolute configuration of novel S-DABO derivatives. 90
Exploring the role of 2-chloro-6-fluoro substitution in 2-alkylthio-6-benzyl-5-alkylpyrimidin-4(3H)-ones: effects in HIV-1-infected cells and in HIV-1 reverse transcriptase enzymes 90
Inhibition of PKCθ Improves Dystrophic Heart Phenotype and Function in a Novel Model of DMD Cardiomyopathy 90
Biochemical functions and clinical characterizations of the sirtuins in diabetes-induced retinal pathologies 90
Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells 89
Pure diastereomers of a tranylcypromine-based LSD1 inhibitor: enzyme selectivity and in-cell studies 89
Sirtuin modulators: an updated patent review (2012 - 2014) 88
3-D QSAR Studies on Histone Deacetylase Inhibitors. A GOLPE/GRID Approach on Different Series of Compounds. 88
3-(4-aroyl-1h-pyrrol-2-yl)-N-hydroxy-2-propenamides, a new class of synthetic histone deacetylase inhibitors 88
KAT3B-p300 and H3AcK18/H3AcK14 levels are prognostic markers for kidney ccRCC tumor aggressiveness and target of KAT inhibitor CPTH2 88
Nitric oxide determines mesodermic differentiation of mouse embryonic stem cells by activating class IIa histone deacetylases: potential therapeutic implications in a mouse model of hindlimb ischemia 87
Developing novel non-hydroxamate histone deacetylase inhibitors: the chelidamic warhead. 87
Novel Cinnamyl Hydroxyamides and 2-Aminoanilides as Histone Deacetylase Inhibitors: Apoptotic Induction and Cytodifferentiation Activity 87
Novel coumarin- and quinolinone-based polycycles as cell division cycle 25-A and -C phosphatases inhibitors induce proliferation arrest and apoptosis in cancer cells 87
EZH2, HIF-1, and their inhibitors: An overview on pediatric cancers 87
Cytoplasmic HDAC4 regulates the membrane repair mechanism in Duchenne muscular dystrophy 87
Pyrrole- and indole-containing tranylcypromine derivatives as novel lysine-specific demethylase 1 inhibitors active on cancer cells. 86
Effects of class II-selective histone deacetylase inhibitor on neuromuscular function and disease progression in SOD1-ALS mice 85
Identification of novel quinazoline derivatives as potent antiplasmodial agents 85
Histone acetyltransferase inhibitor CPTH6 preferentially targets lung cancer stem-like cells 85
Epigenetic polypharmacology: a new frontier for epi-drug discovery 85
Pyrrylphenylethanones Related to Cathinone and Lefetamine : Synthesis and Pharmacological Activities. 84
Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features 84
5-Alkyl-2-alkylamino-6-(2,6-difluorophenylalkyl)-3,4-dihydropyrimidin-4(3H)-ones, a new series of potent, broad-spectrum non-nucleoside reverse transcriptase inhibitors belonging to the DABO family 84
Enhancing sensitivity of triple-negative breast cancer to DNA-damaging therapy through chemical inhibition of the m6A methyltransferase METTL3 83
New Aroyl-Pyrrolyl-Hydroxy-Amides APHAs: Class I and II Histone Deacetylase Inhibiting Activity and Binding Mode Analysis through Molecular Docking Experiments 83
6-(3-methylbenzyl)-2-(2-methylpropyl)thio-4(3h)-pyrimidinone (dabo 622) 83
Application of 3 μm particle-based amylose-derived chiral stationary phases for the enantioseparation of potential histone deacetylase inhibitors. 83
Characterization of Sirtuin Inhibitors in Nematodes Expressing a Muscular Dystrophy Protein Reveals Muscle Cell and Behavioral Protection by Specific Sirtinol Analogues 83
Proteomic profile of differentially expressed plasma proteins from dystrophic mice and following suberoylanilide hydroxamic acid treatment 83
3-(1H-pyrrol-1-yl)-2-oxazolidinones as reversible, highly potent, and selective inhibitors of monoamine oxidase type A. 83
5-alkyl-2-(alkylthio)-6-(2,6-dihalophenylmethyl)-3,4-dihydropyrimidin-4(3h)-ones: novel potent and selective dihydro-alkoxy-benzyl-oxopyrimidine derivatives 83
Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities 82
Pyrazole-based inhibitors of enhancer of zeste homologue 2 induce apoptosis and autophagy in cancer cells 82
Quinoline-based p300 histone acetyltransferase inhibitors with pro-apoptotic activity in human leukemia U937 cells. 82
Epi-drugs in combination with immunotherapy: a new avenue to improve anticancer efficacy 82
Discovery of a novel inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) as orally active antitumor agent 82
3-(1H-Pyrrol-2-yl)-2-oxazolidinones as novel monoamine oxidase type A inhibitors. 81
A Nitric Oxide-dependent crosstalk between class I and III Histone Deacetylases accelerates skin repair. 81
Carprofen Analogues as Sirtuin Inhibitors: Enzyme and Cellular Studies 81
EZH2 inhibitors: a patent review (2014-2016) 81
3,4-Dihydro-2-alkoxy-6-benzyl-oxopyrimidines (DABOs): Development of a Potent Class of Non-nucleoside Reverse Transcriptase Inhibitors 81
Amphetamine and the Smart Drug 3,4-Methylenedioxypyrovalerone (MDPV) Induce Generalization of Fear Memory in Rats 81
Targeting the anti-apoptotic Bcl-2 family proteins: Machine learning virtual screening and biological evaluation of new small molecules 81
3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-alkylamides as a New Class of Synthetic Histone Deacetylase Inhibitors. 1. Design, Synthesis, Biological Evaluation, and Binding Mode Studies Performed through Three Different Docking Procedures 80
Histone deacetylase inhibitors restore IL-10 expression in lipopolysaccharide-induced cell inflammation and reduce IL-1β and IL-6 production in breast silicone implant in C57BL/6J wild-type murine model 80
The relevance of Ki calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor. 80
Discovery of inhibitors for the ether lipid-generating enzyme AGPS as anti-cancer agents 80
Lysine deacetylase inhibitors in parasites: past, present, and future perspectives. 80
5,6-dihydro-4H-pyrrolo(1,2-a)(1,4)benzodiazepine-4,4-diacetic acid diethyl ester, an useful synthon for the synthesis of new polycyclic nitrogen systems of pharmacological interest 80
The Polycomb group (PcG) protein EZH2 supports the survival of PAX3-FOXO1 alveolar rhabdomyosarcoma by repressing FBXO32 (Atrogin1/MAFbx) 80
Aroyl-pyrrolyl hydroxyamides: Influence of pyrrole C4-phenylacetyl substitution on histone deacetylase inhibition 79
Lysine acetyltransferase inhibitors: structure-activity relationships and potential therapeutic implications 79
Interplay among nucleosomal DNA, histone tails, and corepressor CoREST underlies LSD1-mediated H3 demethylation 79
Pyrrole-Based Hydroxamates and 2-Aminoanilides: Histone Deacetylase Inhibition and Cellular Activities 79
Totale 9.454
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Categoria #
all - tutte 80.105
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 1.774
selected - selezionate 0
volume - volumi 0
Totale 81.879
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20204.500 0 0 0 0 531 864 843 677 640 418 272 255
2020/20212.213 266 288 138 150 60 144 81 194 248 324 235 85
2021/20224.529 48 290 466 370 521 108 126 497 346 298 665 794
2022/20234.622 814 1.080 218 453 432 514 102 270 387 110 164 78
2023/20243.154 173 272 238 177 285 810 139 268 44 294 239 215
2024/20251.606 323 206 351 359 367 0 0 0 0 0 0 0
Totale 26.444