The synthesis of various pyrrylphenylethanones resembling cathinone and lefetamine is described starting from 2-chloro-1-(1-methyl-1H-pyrrol-2-yl)-2-phenylethan-1-one. Some derivatives showed good antinociceptic activity, comparable to that of morphine. The neuropsychopharmacological profile of title compounds has been also studied to explore their action on C.N.S.
Pyrrylphenylethanones Related to Cathinone and Lefetamine : Synthesis and Pharmacological Activities / Massa, S; DI SANTO, Roberto; Mai, Antonello; Artico, M; PANTALEONI G., C; Giorgi, R; Coppolino, M. F.. - In: ARCHIV DER PHARMAZIE. - ISSN 0365-6233. - STAMPA. - 325:(1992), pp. 403-409. [10.1002/ardp.19923250707]
Pyrrylphenylethanones Related to Cathinone and Lefetamine : Synthesis and Pharmacological Activities.
DI SANTO, Roberto;MAI, Antonello;
1992
Abstract
The synthesis of various pyrrylphenylethanones resembling cathinone and lefetamine is described starting from 2-chloro-1-(1-methyl-1H-pyrrol-2-yl)-2-phenylethan-1-one. Some derivatives showed good antinociceptic activity, comparable to that of morphine. The neuropsychopharmacological profile of title compounds has been also studied to explore their action on C.N.S.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
