Catalogo dei prodotti della ricerca

PAIARDINI, ALESSANDRO
 Distribuzione geografica
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Continente #
NA - Nord America 6.106
EU - Europa 2.491
AS - Asia 750
AF - Africa 50
SA - Sud America 28
Continente sconosciuto - Info sul continente non disponibili 1
OC - Oceania 1
Totale 9.427
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Nazione #
US - Stati Uniti d'America 5.934
IT - Italia 1.551
SE - Svezia 299
IN - India 236
CN - Cina 233
SG - Singapore 220
CA - Canada 152
FI - Finlandia 124
UA - Ucraina 94
DE - Germania 81
BG - Bulgaria 61
ES - Italia 60
GB - Regno Unito 59
IE - Irlanda 38
FR - Francia 36
TG - Togo 34
AR - Argentina 20
NL - Olanda 20
IR - Iran 15
BZ - Belize 13
RO - Romania 12
BE - Belgio 10
CZ - Repubblica Ceca 10
JP - Giappone 10
TR - Turchia 10
AT - Austria 8
HK - Hong Kong 8
ZA - Sudafrica 8
DK - Danimarca 7
MA - Marocco 7
MX - Messico 7
PL - Polonia 5
CH - Svizzera 4
KR - Corea 4
BR - Brasile 3
EE - Estonia 3
ID - Indonesia 3
NO - Norvegia 3
CL - Cile 2
CO - Colombia 2
CY - Cipro 2
IQ - Iraq 2
PK - Pakistan 2
AM - Armenia 1
AU - Australia 1
EG - Egitto 1
EU - Europa 1
GR - Grecia 1
HU - Ungheria 1
IL - Israele 1
LV - Lettonia 1
MY - Malesia 1
PH - Filippine 1
PT - Portogallo 1
RS - Serbia 1
SA - Arabia Saudita 1
SI - Slovenia 1
VE - Venezuela 1
Totale 9.427
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Città #
Fairfield 863
Ashburn 745
Rome 735
Woodbridge 411
Houston 339
Chandler 322
Seattle 312
Cambridge 301
Wilmington 261
Ann Arbor 211
Dearborn 167
New York 166
Princeton 153
Ottawa 124
Washington 115
Plano 106
San Paolo di Civitate 90
Lawrence 87
Milan 86
Singapore 86
Beijing 73
Boston 72
Millbury 69
San Diego 65
Sofia 61
Fremont 59
Dublin 38
San Jose 38
Andover 35
Lomé 34
Boardman 31
Helsinki 29
Norwalk 28
Jacksonville 27
Falls Church 22
Toronto 22
Hefei 21
San Mateo 21
Albano Laziale 19
Bremen 19
Federal 19
Pallejà 19
Nanjing 18
Kunming 16
Las Vegas 16
Buffalo 14
Belize City 13
Fasano 13
Mannheim 13
Sant Vicenç dels Horts 13
Phoenix 12
Ariccia 11
Jinan 11
Palermo 11
Sacrofano 11
Shanghai 11
Treviso 11
Barcelona 10
Bologna 10
Bühl 10
Los Angeles 10
Manresa 10
Paris 10
Florence 9
Guangzhou 9
Cisterna di Latina 8
Des Moines 8
Nanchang 8
Olomouc 8
Redwood City 8
Verona 8
Bari 7
London 7
Brussels 6
Cagliari 6
Grafing 6
Hong Kong 6
Lappeenranta 6
Marino 6
Naples 6
Pavia 6
Philadelphia 6
Saint Louis 6
Santa Cruz 6
Southampton 6
Chengdu 5
Chicago 5
Ferentino 5
Marseille 5
Palo Alto 5
Rieti 5
Torre del Greco 5
Udine 5
Zhengzhou 5
Ankara 4
Changsha 4
Columbus 4
Crotone 4
Fabrica di Roma 4
Izmir 4
Totale 6.976
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Nome #
The moonlighting RNA-binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism 143
Differential 3-bromopyruvate inhibition of cytosolic and mitochondrial human serine hydroxymethyltransferase isoforms, key enzymes in cancer metabolic reprogramming 130
PyMod: sequence similarity searches, multiple sequence-structure alignments, and homology modeling within PyMOL 120
Pyridoxine-5'-phosphate oxidase (pnpo) deficiency. clinical and biochemical alterations associated with the c.347g>a (pp. arg116gln) mutation 115
Threonine aldolase and alanine racemase: novel examples of convergent evolution in the superfamily of vitamin B6-dependent enzymes 113
Biochemical data from the characterization of a new pathogenic mutation of human pyridoxine-5'-phosphate oxidase (PNPO) 113
Screening and in vitro testing of antifolate inhibitors of human cytosolic serine hydroxymethyltransferase 113
A conserved scaffold with heterogeneous metal ion binding site: the multifaceted example of HD-GYP proteins 112
Custom scoring Aurora-A with SMINA 110
The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells 107
Bioinformatica: dalla sequenza alla struttura delle proteine 106
The phytotoxin fusicoccin differently regulates 14-3-3 proteins association to mode III targets. 103
How pyridoxal 5'-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state 100
Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex 100
Human wild-type alanine : glyoxylate aminotransferase and its naturally occurring G82E variant: functional properties and physiological implications 99
CAMPO, SCR_FIND and CHC_FIND: a suite of web tools for computational structural biology 98
Molecular analysis of sarcomeric and non-sarcomeric genes in patients with hypertrophic cardiomyopathy. 98
Insights into the GTP-dependent allosteric control of c-di-GMP hydrolysis from the crystal structure of PA0575 protein from Pseudomonas aeruginosa 97
Glycine consumption and mitochondrial serine hydroxymethyltransferase in cancer cells: the heme connection 94
Studying ggdef domain in the act: Minimize conformational frustration to prevent artefacts 92
Expression of Bv8 in pichia pastoris to identify structural features for receptor binding 90
Intronic determinants coordinate charme lncRNA nuclear activity through the interaction with MATR3 and PTBP1 90
Synthesis of triazole-linked analogues of c-di-gmp and their interactions with diguanylate cyclase 88
Discovering selective diguanylate cyclase inhibitors: From PleD to discrimination of the active site of cyclic-di-GMP phosphodiesterases 88
N6-Methyladenosine (m6A): A Promising New Molecular Target in Acute Myeloid Leukemia 88
Prediction and visualization data for the interpretation of sarcomeric and non-sarcomeric DNA variants found in patients with hypertrophic cardiomyopathy 87
Insights into the interaction of sortilin with proneurotrophins: A computational approach 86
Corrigendum to “Pyridoxine-5′-phosphate oxidase (Pnpo) deficiency: Clinical and biochemical alterations associated with the C.347g > A (P.·Arg116gln) mutation” [Mol. Genet. Metab. 122/1–2 (2017) 135–142] 85
R180T variant of δ-ornithine aminotransferase associated with gyrate atrophy: biochemical, computational, X-ray and NMR studies provide insight into its catalytic features 85
A truncated and catalytically inactive isoform of KDM5B histone demethylase accumulates in breast cancer cells and regulates H3K4 tri-methylation and gene expression 84
A novel bacterial l-arginine sensor controlling c-di-GMP levels in Pseudomonas aeruginosa 84
SMaRT lncRNA controls translation of a G-quadruplex-containing mRNA antagonizing the DHX36 helicase 84
Structural basis of functional diversification of the HD-GYP domain revealed by the pseudomonas aeruginosa PA4781 protein, which displays an unselective bimetallic binding site 83
Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex 82
Structural stability of the cofactor binding site in Escherichia coli serine hydroxymethyltransferase--the role of evolutionarily conserved hydrophobic contacts. 81
In silico and in vitro validation of serine hydroxymethyltransferase as a chemotherapeutic target of the antifolate drug pemetrexed 81
Structural mimicry between SLA/LP and Rickettsia surface antigens as a driver of autoimmune hepatitis: insights from an in silico study 81
A 3D model of Reelin subrepeat regions predicts Reelin binding to carbohydrates 80
Molecular defects of the glycine 41 variants of alanine glyoxylate aminotransferase associated with primary hyperoxaluria type I. 80
SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation 79
Alanine racemase from Tolypocladium inflatum: A key PLP-dependent enzyme in cyclosporin biosynthesis and a model of catalytic promiscuity 79
Betulinic acid is a PPARγ antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis 79
Molecular insight into the synergism between the minor allele of human liver peroxisomal alanine: Glyoxylate aminotransferase and the F152I mutation. 78
Identification of small molecule inhibitors of the aurora-A/TPX2 complex 78
The archaeal elongation factor EF-2 induces the release of aIF6 from 50S ribosomal subunit 78
Treponema denticola cystalysin exhibits significant alanine racemase activity accompanied by transamination: mechanistic implications 78
Glucose metabolism in the progression of prostate cancer 77
Differential inhibitory effect of a pyrazolopyran compound on human serine hydroxymethyltransferase-amino acid complexes 77
Functional characterization and structure-guided mutational analysis of the transsulfuration enzyme cystathionine γ-lyase from toxoplasma gondii 77
Cytosolic serine hydroxymethyltransferase controls lung adenocarcinoma cells migratory ability by modulating AMP kinase activity 77
C-di-GMP Hydrolysis by Pseudomonas aeruginosa HD-GYP Phosphodiesterases: Analysis of the Reaction Mechanism and Novel Roles for pGpG 76
Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions 75
Structural investigation of nucleophosmin interaction with the tumor suppressor Fbw7γ 74
A novel germline mutation in CDK4 codon 24 associated to familial melanoma 74
A novel compound heterozygous genotype associated with aromatic amino acid decarboxylase deficiency: Clinical aspects and biochemical studies 74
A pyrazolopyran derivative preferentially inhibits the activity of human cytosolic hydroxymethyltransferase and induces cell death in lung cancer cells 71
Investigating the allosteric regulation of YfiN from Pseudomonas aeruginosa: Clues from the structure of the catalytic domain 70
L-Threonine aldolase, serine hydroxymethyltransferase and fungal alanine racemase. A subsgroup of strictly related enzymes specialized for different functions 70
MOLECULAR DEFECTS OF THE GLYCINE 41 VARIANTS OF ALANINE:GLYOXYLATE AMINOTRANSFERASE ASSOCIATED WITH PRIMARY HYPEROXALURIA TYPE I 69
The role of evolutionarily conserved hydrophobic contacts in the quaternary structure stability of Escherichia coli serine hydroxymethyltransferase 68
Chemogenomics of pyridoxal 5'-phosphate dependent enzymes. 68
Prenatal whole exome sequencing detects a new homozygous fukutin (FKTN) mutation in a fetus with an ultrasound suspicion of familial Dandy-Walker malformation. 68
L- Arginine in Pseudomonas aeruginosa controls c-di-GMP levels and biofilm formation 68
An engineered folded PLP-bound monomer of Treponema denticola cystalysin reveals the effect of the dimeric structure on the catalytic properties of the enzyme. 67
Structural plasticity of thermophilic serine hydroxymethyltransferase 67
Evolutionarily conserved regions and hydrophobic contacts at the superfamily level: The case of the fold-type I, pyridoxal-5'-phosphate-dependent enzymes 67
Identification and validation of a potent dual Inhibitor of the P. falciparum M1 and M17 aminopeptidases using virtual screening 67
Familial hypomagnesaemia, Hypercalciuria and Nephrocalcinosis associated with a novel mutation of the highly conserved leucine residue 116 of Claudin 16 in a Chinese patient with a delayed diagnosis: A case report 67
Mutational analysis and homology modelling of SyrC, the aminoacyltransferase in the biosynthesis of syringomycin 66
Structural adaptation of extreme halophilic proteins through decrease of conserved hydrophobic contact surface 65
New insights emerging from recent investigations on Human Group II pyridoxal 5'-phosphate decarboxylases 64
The novel R347G pathogenic mutation of aromatic amino acid decarboxylase provides additional molecular insights into enzyme catalysis and deficiency 64
“L-Threonine aldolase, serine hydroxymethyltransferase and fungal alanine racemase. A subgroup of strictly related enzymes specialized for different functions”, in the 3rd International Symposium on Vitamin B6, PQQ, Carbonyl Catalysis and Quinoproteins, Southampton, United Kingdom, 14-19 April 2002. 64
Molecular cloning of the biosynthetic cluster involved in the production of 4-chlorothreonine in Streptomyces sp. OH-5093: insight into the structure-activity relationship of a new nonheme Fe(II) halogenase 63
Cysteine 180 is a redox sensor modulating activity of human pyridoxal 5'-phosphate histidine decarboxylase 63
Identification by Virtual Screening and In Vitro Testing of Human DOPA Decarboxylase Inhibitors 62
X-ray crystal structures of an orally available aminopeptidase inhibitor, Tosedostat, bound to anti-malarial drug targets PfA-M1 and PfA-M17 62
Molecular insights into primary hyperoxaluria type i pathogenesis 61
Unique substrate specificity of ornithine aminotransferase from Toxoplasma gondii 61
Structural analysis of toxic volkensin, a type 2 ribosome inactivating protein from Adenia volkensii Harm (kilyambiti plant): Molecular modeling and surface analysis by computational methods and limited proteolysis 61
Insights into pparγphosphorylation and its inhibition mechanism 61
IN SILICO AND IN VITRO VALIDATION OF SERINE HYDROXYMETHYLTRANSFERASE AS A CHEMOTHERAPEUTIC TARGET OF THE ANTIFOLATE DRUG PEMETREXED. 60
On the catalytic mechanism and stereospecificity of Escherichia coli L-threonine aldolase 60
Type I pyridoxal 5'-phosphate dependent enzymatic domains embedded within multimodular nonribosomal peptide synthetase and polyketide synthase assembly lines. 60
Artemisinin derivatives with antimelanoma activity show inhibitory effect against human dna topoisomerase 1 60
Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases 60
Radiation damage at the active site of human alanine:glyoxylate aminotransferase reveals that the cofactor position is finely tuned during catalysis 59
Structural plasticity of thermophilic serine hydroxymethyltransferases 59
From PARP1 to TNKS2 inhibition: A structure-based approach 59
Crystal structure of the S187F variant of human liver alanine: Aminotransferase associated with primary hyperoxaluria type I and its functional implications 58
AurkA nuclear localization is promoted by TPX2 and counteracted by protein degradation 57
Insight into the structure-function relationship of the nonheme iron halogenases involved in the biosynthesis of 4-chlorothreonine-Thr3 from Streptomyces sp OH-5093 and SyrB2 from Pseudomonas syringae pv. syringae B301DR 55
Bivalent binding of staphylococcal superantigens to the TCR and CD28 triggers inflammatory signals independently of antigen presenting cells 53
null 53
Identification of the pyridoxal 5′‐phosphate allosteric site in human pyridox(am)ine 5′‐phosphate oxidase 52
A strategy for detection of structural conserved regions and contacts in protein superfamilies: application to the PLP-dependent enzymes 52
COMUNICAZIONE ORALE A CONGRESSO SU INVITO “Studies on the evolutionary origins of pyridoxal-phosphate-dependent enzymes: catalytic promiscuity and reaction specificity”, in “Quo Vadis Proteomics”, Napoli, 26 Marzo 2001. 52
The immunosuppressive drug azathioprine inhibits biosynthesis of the bacterial signal molecule cyclic-di-GMP by interfering with intracellular nucleotide pool availability 52
PLP-dependent enzymes. 51
"Hot cores" in proteins: Comparative analysis of the apolar contact area in structures from hyper/thermophilic and mesophilic organisms 51
Totale 7.767
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Categoria #
all - tutte 27.602
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 27.602
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.839 230 51 41 99 172 323 303 206 187 106 67 54
2020/2021909 65 68 33 84 39 88 63 68 109 170 94 28
2021/20221.890 31 129 146 165 193 63 77 224 157 111 302 292
2022/20231.811 272 283 65 234 148 229 49 121 139 56 132 83
2023/20241.981 109 128 202 195 225 519 87 110 26 141 117 122
2024/2025162 162 0 0 0 0 0 0 0 0 0 0 0
Totale 9.989