Catalogo dei prodotti della ricerca

PAIARDINI, ALESSANDRO
 Distribuzione geografica
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Continente #
NA - Nord America 6.341
EU - Europa 2.797
AS - Asia 1.164
AF - Africa 53
SA - Sud America 29
OC - Oceania 4
Continente sconosciuto - Info sul continente non disponibili 1
Totale 10.389
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Nazione #
US - Stati Uniti d'America 6.162
IT - Italia 1.738
SG - Singapore 430
CN - Cina 365
SE - Svezia 299
IN - India 239
CA - Canada 157
FI - Finlandia 153
DE - Germania 111
UA - Ucraina 94
GB - Regno Unito 72
BG - Bulgaria 61
ID - Indonesia 58
ES - Italia 57
IE - Irlanda 39
FR - Francia 37
TG - Togo 34
RU - Federazione Russa 30
NL - Olanda 25
AR - Argentina 20
IR - Iran 15
BZ - Belize 13
AT - Austria 12
RO - Romania 12
JP - Giappone 11
BE - Belgio 10
CZ - Repubblica Ceca 10
HK - Hong Kong 10
TR - Turchia 10
KR - Corea 9
MX - Messico 9
DK - Danimarca 8
ZA - Sudafrica 8
MA - Marocco 7
PT - Portogallo 6
PL - Polonia 5
BR - Brasile 4
CH - Svizzera 4
EE - Estonia 4
AU - Australia 3
EG - Egitto 3
NO - Norvegia 3
CL - Cile 2
CO - Colombia 2
CY - Cipro 2
HU - Ungheria 2
IL - Israele 2
IQ - Iraq 2
PK - Pakistan 2
UZ - Uzbekistan 2
AM - Armenia 1
EU - Europa 1
GR - Grecia 1
KZ - Kazakistan 1
LA - Repubblica Popolare Democratica del Laos 1
LT - Lituania 1
LV - Lettonia 1
MY - Malesia 1
NG - Nigeria 1
NZ - Nuova Zelanda 1
PH - Filippine 1
RS - Serbia 1
SA - Arabia Saudita 1
SI - Slovenia 1
TW - Taiwan 1
VE - Venezuela 1
Totale 10.389
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Città #
Fairfield 863
Rome 837
Ashburn 750
Woodbridge 411
Houston 339
Chandler 322
Seattle 313
Cambridge 301
Singapore 292
Wilmington 261
Ann Arbor 211
Dearborn 167
New York 167
Princeton 153
Santa Clara 147
Ottawa 125
Washington 115
Plano 106
San Paolo di Civitate 90
Milan 88
Lawrence 87
Beijing 82
Boston 72
Millbury 69
San Diego 65
Fremont 61
Sofia 61
Helsinki 56
Jakarta 54
Dublin 39
San Jose 38
Boardman 37
Andover 35
Lomé 34
Norwalk 28
Jacksonville 27
Toronto 26
Falls Church 22
Hefei 21
Nanjing 21
San Mateo 21
Bremen 19
Federal 19
Kunming 18
Las Vegas 18
Albano Laziale 17
Mannheim 17
Moscow 17
Shanghai 17
Palermo 15
Buffalo 14
Guangzhou 14
Pallejà 14
Belize City 13
Fasano 13
Phoenix 13
Sant Vicenç dels Horts 13
Ariccia 11
Florence 11
Jinan 11
Treviso 11
Bologna 10
Bühl 10
Los Angeles 10
Manresa 10
Paris 10
Sacrofano 10
Barcelona 9
Dallas 9
London 9
Nanchang 9
Cisterna di Latina 8
Des Moines 8
Falkenstein 8
Lappeenranta 8
Marino 8
Naples 8
Olomouc 8
Redwood City 8
Southampton 8
Verona 8
Bari 7
Hong Kong 7
Turin 7
Zhengzhou 7
Brussels 6
Cagliari 6
Francavilla Marittima 6
Grafing 6
Pavia 6
Pescara 6
Philadelphia 6
Saint Louis 6
Santa Cruz 6
Wuhan 6
Chengdu 5
Chicago 5
Columbus 5
Ferentino 5
Incheon 5
Totale 7.598
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Nome #
The moonlighting RNA-binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism 149
Differential 3-bromopyruvate inhibition of cytosolic and mitochondrial human serine hydroxymethyltransferase isoforms, key enzymes in cancer metabolic reprogramming 136
Custom scoring Aurora-A with SMINA 127
PyMod: sequence similarity searches, multiple sequence-structure alignments, and homology modeling within PyMOL 123
A conserved scaffold with heterogeneous metal ion binding site: the multifaceted example of HD-GYP proteins 122
The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells 119
Bioinformatica: dalla sequenza alla struttura delle proteine 118
Screening and in vitro testing of antifolate inhibitors of human cytosolic serine hydroxymethyltransferase 118
Pyridoxine-5'-phosphate oxidase (pnpo) deficiency. clinical and biochemical alterations associated with the c.347g>a (pp. arg116gln) mutation 116
Threonine aldolase and alanine racemase: novel examples of convergent evolution in the superfamily of vitamin B6-dependent enzymes 115
Biochemical data from the characterization of a new pathogenic mutation of human pyridoxine-5'-phosphate oxidase (PNPO) 115
Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex 109
Molecular analysis of sarcomeric and non-sarcomeric genes in patients with hypertrophic cardiomyopathy. 108
The phytotoxin fusicoccin differently regulates 14-3-3 proteins association to mode III targets. 108
How pyridoxal 5'-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state 106
Studying ggdef domain in the act: Minimize conformational frustration to prevent artefacts 105
Intronic determinants coordinate charme lncRNA nuclear activity through the interaction with MATR3 and PTBP1 104
Insights into the GTP-dependent allosteric control of c-di-GMP hydrolysis from the crystal structure of PA0575 protein from Pseudomonas aeruginosa 103
CAMPO, SCR_FIND and CHC_FIND: a suite of web tools for computational structural biology 100
Human wild-type alanine : glyoxylate aminotransferase and its naturally occurring G82E variant: functional properties and physiological implications 100
Glycine consumption and mitochondrial serine hydroxymethyltransferase in cancer cells: the heme connection 97
Expression of Bv8 in pichia pastoris to identify structural features for receptor binding 94
N6-Methyladenosine (m6A): A Promising New Molecular Target in Acute Myeloid Leukemia 94
Discovering selective diguanylate cyclase inhibitors: From PleD to discrimination of the active site of cyclic-di-GMP phosphodiesterases 93
A truncated and catalytically inactive isoform of KDM5B histone demethylase accumulates in breast cancer cells and regulates H3K4 tri-methylation and gene expression 92
Synthesis of triazole-linked analogues of c-di-gmp and their interactions with diguanylate cyclase 92
SMaRT lncRNA controls translation of a G-quadruplex-containing mRNA antagonizing the DHX36 helicase 92
A novel bacterial l-arginine sensor controlling c-di-GMP levels in Pseudomonas aeruginosa 91
Prediction and visualization data for the interpretation of sarcomeric and non-sarcomeric DNA variants found in patients with hypertrophic cardiomyopathy 90
R180T variant of δ-ornithine aminotransferase associated with gyrate atrophy: biochemical, computational, X-ray and NMR studies provide insight into its catalytic features 90
Cytosolic serine hydroxymethyltransferase controls lung adenocarcinoma cells migratory ability by modulating AMP kinase activity 90
Structural basis of functional diversification of the HD-GYP domain revealed by the pseudomonas aeruginosa PA4781 protein, which displays an unselective bimetallic binding site 89
Insights into the interaction of sortilin with proneurotrophins: A computational approach 89
Corrigendum to “Pyridoxine-5′-phosphate oxidase (Pnpo) deficiency: Clinical and biochemical alterations associated with the C.347g > A (P.·Arg116gln) mutation” [Mol. Genet. Metab. 122/1–2 (2017) 135–142] 89
Identification of the pyridoxal 5′‐phosphate allosteric site in human pyridox(am)ine 5′‐phosphate oxidase 88
Alanine racemase from Tolypocladium inflatum: A key PLP-dependent enzyme in cyclosporin biosynthesis and a model of catalytic promiscuity 87
Differential inhibitory effect of a pyrazolopyran compound on human serine hydroxymethyltransferase-amino acid complexes 86
Betulinic acid is a PPARγ antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis 86
L- Arginine in Pseudomonas aeruginosa controls c-di-GMP levels and biofilm formation 86
Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex 86
The archaeal elongation factor EF-2 induces the release of aIF6 from 50S ribosomal subunit 85
Structural stability of the cofactor binding site in Escherichia coli serine hydroxymethyltransferase--the role of evolutionarily conserved hydrophobic contacts. 84
In silico and in vitro validation of serine hydroxymethyltransferase as a chemotherapeutic target of the antifolate drug pemetrexed 84
SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation 84
A 3D model of Reelin subrepeat regions predicts Reelin binding to carbohydrates 84
Functional characterization and structure-guided mutational analysis of the transsulfuration enzyme cystathionine γ-lyase from toxoplasma gondii 84
Identification of small molecule inhibitors of the aurora-A/TPX2 complex 84
Glucose metabolism in the progression of prostate cancer 83
Structural mimicry between SLA/LP and Rickettsia surface antigens as a driver of autoimmune hepatitis: insights from an in silico study 83
Molecular defects of the glycine 41 variants of alanine glyoxylate aminotransferase associated with primary hyperoxaluria type I. 83
A novel compound heterozygous genotype associated with aromatic amino acid decarboxylase deficiency: Clinical aspects and biochemical studies 81
Treponema denticola cystalysin exhibits significant alanine racemase activity accompanied by transamination: mechanistic implications 81
Structural investigation of nucleophosmin interaction with the tumor suppressor Fbw7γ 80
C-di-GMP Hydrolysis by Pseudomonas aeruginosa HD-GYP Phosphodiesterases: Analysis of the Reaction Mechanism and Novel Roles for pGpG 80
Molecular insight into the synergism between the minor allele of human liver peroxisomal alanine: Glyoxylate aminotransferase and the F152I mutation. 79
A pyrazolopyran derivative preferentially inhibits the activity of human cytosolic hydroxymethyltransferase and induces cell death in lung cancer cells 78
Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions 78
A novel germline mutation in CDK4 codon 24 associated to familial melanoma 75
Prenatal whole exome sequencing detects a new homozygous fukutin (FKTN) mutation in a fetus with an ultrasound suspicion of familial Dandy-Walker malformation. 75
Investigating the allosteric regulation of YfiN from Pseudomonas aeruginosa: Clues from the structure of the catalytic domain 74
L-Threonine aldolase, serine hydroxymethyltransferase and fungal alanine racemase. A subsgroup of strictly related enzymes specialized for different functions 74
Structure-based mechanism of riboregulation of the metabolic enzyme SHMT1 73
The role of evolutionarily conserved hydrophobic contacts in the quaternary structure stability of Escherichia coli serine hydroxymethyltransferase 72
Bivalent binding of staphylococcal superantigens to the TCR and CD28 triggers inflammatory signals independently of antigen presenting cells 71
Mutational analysis and homology modelling of SyrC, the aminoacyltransferase in the biosynthesis of syringomycin 71
An engineered folded PLP-bound monomer of Treponema denticola cystalysin reveals the effect of the dimeric structure on the catalytic properties of the enzyme. 70
Structural plasticity of thermophilic serine hydroxymethyltransferase 70
Identification and validation of a potent dual Inhibitor of the P. falciparum M1 and M17 aminopeptidases using virtual screening 70
Familial hypomagnesaemia, Hypercalciuria and Nephrocalcinosis associated with a novel mutation of the highly conserved leucine residue 116 of Claudin 16 in a Chinese patient with a delayed diagnosis: A case report 70
Molecular cloning of the biosynthetic cluster involved in the production of 4-chlorothreonine in Streptomyces sp. OH-5093: insight into the structure-activity relationship of a new nonheme Fe(II) halogenase 69
Evolutionarily conserved regions and hydrophobic contacts at the superfamily level: The case of the fold-type I, pyridoxal-5'-phosphate-dependent enzymes 69
MOLECULAR DEFECTS OF THE GLYCINE 41 VARIANTS OF ALANINE:GLYOXYLATE AMINOTRANSFERASE ASSOCIATED WITH PRIMARY HYPEROXALURIA TYPE I 69
Structural adaptation of extreme halophilic proteins through decrease of conserved hydrophobic contact surface 69
Chemogenomics of pyridoxal 5'-phosphate dependent enzymes. 68
Insights into pparγphosphorylation and its inhibition mechanism 68
Artemisinin derivatives with antimelanoma activity show inhibitory effect against human dna topoisomerase 1 67
AurkA nuclear localization is promoted by TPX2 and counteracted by protein degradation 67
Identification by Virtual Screening and In Vitro Testing of Human DOPA Decarboxylase Inhibitors 66
“L-Threonine aldolase, serine hydroxymethyltransferase and fungal alanine racemase. A subgroup of strictly related enzymes specialized for different functions”, in the 3rd International Symposium on Vitamin B6, PQQ, Carbonyl Catalysis and Quinoproteins, Southampton, United Kingdom, 14-19 April 2002. 66
New insights emerging from recent investigations on Human Group II pyridoxal 5'-phosphate decarboxylases 65
The novel R347G pathogenic mutation of aromatic amino acid decarboxylase provides additional molecular insights into enzyme catalysis and deficiency 65
On the catalytic mechanism and stereospecificity of Escherichia coli L-threonine aldolase 64
X-ray crystal structures of an orally available aminopeptidase inhibitor, Tosedostat, bound to anti-malarial drug targets PfA-M1 and PfA-M17 64
From PARP1 to TNKS2 inhibition: A structure-based approach 64
Molecular insights into primary hyperoxaluria type i pathogenesis 63
Cysteine 180 is a redox sensor modulating activity of human pyridoxal 5'-phosphate histidine decarboxylase 63
Unique substrate specificity of ornithine aminotransferase from Toxoplasma gondii 63
Radiation damage at the active site of human alanine:glyoxylate aminotransferase reveals that the cofactor position is finely tuned during catalysis 63
Structural analysis of toxic volkensin, a type 2 ribosome inactivating protein from Adenia volkensii Harm (kilyambiti plant): Molecular modeling and surface analysis by computational methods and limited proteolysis 63
Open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases 63
Type I pyridoxal 5'-phosphate dependent enzymatic domains embedded within multimodular nonribosomal peptide synthetase and polyketide synthase assembly lines. 62
Structural plasticity of thermophilic serine hydroxymethyltransferases 61
Nutrient sensing and biofilm modulation: the example of L-arginine in Pseudomonas 61
IN SILICO AND IN VITRO VALIDATION OF SERINE HYDROXYMETHYLTRANSFERASE AS A CHEMOTHERAPEUTIC TARGET OF THE ANTIFOLATE DRUG PEMETREXED. 60
Crystal structure of the S187F variant of human liver alanine: Aminotransferase associated with primary hyperoxaluria type I and its functional implications 60
Insight into the structure-function relationship of the nonheme iron halogenases involved in the biosynthesis of 4-chlorothreonine-Thr3 from Streptomyces sp OH-5093 and SyrB2 from Pseudomonas syringae pv. syringae B301DR 58
"Hot cores" in proteins: Comparative analysis of the apolar contact area in structures from hyper/thermophilic and mesophilic organisms 55
The immunosuppressive drug azathioprine inhibits biosynthesis of the bacterial signal molecule cyclic-di-GMP by interfering with intracellular nucleotide pool availability 55
Design and development of a versatile graphical user interface for assisting consensus docking analyses on therapeutic targets for cancer treatment. 55
A strategy for detection of structural conserved regions and contacts in protein superfamilies: application to the PLP-dependent enzymes 54
Totale 8.321
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Categoria #
all - tutte 34.672
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 40
selected - selezionate 0
volume - volumi 0
Totale 34.712
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.246 0 0 0 0 0 323 303 206 187 106 67 54
2020/2021909 65 68 33 84 39 88 63 68 109 170 94 28
2021/20221.890 31 129 146 165 193 63 77 224 157 111 302 292
2022/20231.811 272 283 65 234 148 229 49 121 139 56 132 83
2023/20241.954 109 128 202 195 225 519 82 100 24 136 113 121
2024/20251.206 161 91 187 249 270 248 0 0 0 0 0 0
Totale 11.006