Catalogo dei prodotti della ricerca

DE SMAELE, Enrico
 Distribuzione geografica
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Continente #
NA - Nord America 3.902
EU - Europa 2.301
AS - Asia 729
SA - Sud America 32
AF - Africa 31
OC - Oceania 5
Totale 7.000
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Nazione #
US - Stati Uniti d'America 3.863
IT - Italia 1.238
SE - Svezia 341
SG - Singapore 277
DE - Germania 254
IN - India 188
CN - Cina 157
FI - Finlandia 107
UA - Ucraina 107
GB - Regno Unito 60
ID - Indonesia 43
RU - Federazione Russa 32
CA - Canada 30
FR - Francia 29
TG - Togo 29
BG - Bulgaria 26
IE - Irlanda 23
AR - Argentina 21
RO - Romania 21
BE - Belgio 17
CH - Svizzera 15
HK - Hong Kong 14
TR - Turchia 14
NL - Olanda 9
KR - Corea 8
MX - Messico 8
JP - Giappone 6
PK - Pakistan 6
CL - Cile 5
ES - Italia 5
BR - Brasile 4
HR - Croazia 4
KZ - Kazakistan 4
PL - Polonia 4
AU - Australia 3
MY - Malesia 3
GR - Grecia 2
NZ - Nuova Zelanda 2
PT - Portogallo 2
AE - Emirati Arabi Uniti 1
AM - Armenia 1
AT - Austria 1
BO - Bolivia 1
BS - Bahamas 1
DK - Danimarca 1
EC - Ecuador 1
GE - Georgia 1
IR - Iran 1
KG - Kirghizistan 1
KW - Kuwait 1
LT - Lituania 1
LV - Lettonia 1
NO - Norvegia 1
SA - Arabia Saudita 1
SC - Seychelles 1
TW - Taiwan 1
UZ - Uzbekistan 1
ZA - Sudafrica 1
Totale 7.000
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Città #
Fairfield 571
Rome 499
Chandler 309
Woodbridge 287
Ashburn 281
Houston 279
Seattle 255
Wilmington 203
Cambridge 193
Singapore 193
Ann Arbor 167
Dearborn 117
San Paolo di Civitate 94
Princeton 89
Santa Clara 72
Beijing 71
Lawrence 69
Plano 65
Fremont 51
Helsinki 47
New York 47
Grafing 45
Jakarta 41
Boston 40
San Diego 40
Jacksonville 38
Millbury 34
Andover 29
Boardman 29
Lomé 29
Bremen 27
Munich 25
Sofia 25
Dublin 22
Milan 22
Federal 18
Toronto 16
Des Moines 15
Phoenix 14
Naples 13
Brussels 12
Norwalk 12
Los Angeles 11
Cerveteri 10
Hong Kong 10
Istanbul 10
Latina 9
London 9
Napoli 9
Redwood City 9
Berlin 8
Falkenstein 8
Nanjing 8
San Benedetto del Tronto 8
Falls Church 7
Fiuggi 7
Moscow 7
Palermo 7
Verona 7
Amsterdam 6
Casalecchio di Reno 6
Mannheim 6
Mexico City 6
Paris 6
Pisa 6
Avellino 5
Bühl 5
Delhi 5
Guangzhou 5
Lappeenranta 5
Ottawa 5
Parma 5
Pune 5
Bacoli 4
Denver 4
Fasano 4
Hefei 4
Nürnberg 4
Sacramento 4
San Mateo 4
Velletri 4
Westminster 4
Zagreb 4
Zurich 4
Arezzo 3
Bucharest 3
Cardiff 3
Casalpusterlengo 3
Civitavecchia 3
Florence 3
Frankfurt am Main 3
Kilburn 3
Kunming 3
Köseköy 3
Leuven 3
Melbourne 3
Menlo Park 3
Minturno 3
Montreal 3
Montréal 3
Totale 4.817
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Nome #
Studio dei meccanismi dell'apoptosi e del ruolo svolto dal fattore di trascrizione NF-kB nella protezione dalla apoptosi. Ricerca di potenziali geni target per le terapie antivirali ed antitumorali. In particolare: - identificazione di una nuova pathway antiapoptotica regolata da una proteina dell’envelope del virus herpes simplex1, gD, che provoca l’attivazione di NF-kappaB; - Identificazione e caratterizzazione di un nuovo gene con funzione antiapoptotica, Gadd45 β, regolato dal fattore di trascrizione NF-kB, e del suo meccanismo d'azione. - Studio della modulazione dei ROS (Reactive Oxygen Species) nella regolazione della apoptosi da parte di NF-kB, ed identificazione di un gene FHC (Ferritin Heavy Chain) coinvolto in questa regolazione. 260
β-arrestin1-mediated acetylation of Gli1 regulates Hedgehog/Gli signaling and modulates self-renewal of SHH medulloblastoma cancer stem cells 164
Foxm1 controls a pro-stemness microRNA network in neural stem cells 151
Mitogen-activated kinase kinase kinase 1 inhibits hedgehog signaling and medulloblastoma growth through GLI1 phosphorylation 140
Non-canonical Hedgehog/ampk-mediated control of polyamine metabolism supports neuronal and medulloblastoma cell growth 136
ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP 134
Curcumin blocks autophagy and activates apoptosis of malignant mesothelioma cell lines and increases the survival of mice intraperitoneally transplanted with a malignant mesothelioma cell line 123
Hedgehog antagonist REN(KCTD11) regulates proliferation and apoptosis of developing granule cell progenitors. 122
Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis 118
Sonic hedgehog medulloblastoma cancer stem cells mirnome and transcriptome highlight novel functional networks 116
Noncanonical GLI1 signaling promotes stemness features and in vivo growth in lung adenocarcinoma 115
The energy sensor AMPK regulates Hedgehog signaling in human cells through a unique Gli1 metabolic checkpoint 113
Phenformin inhibits hedgehog-dependent tumor growth through a complex i-independent redox/corepressor module 113
In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors. 112
Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation 111
Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma. 109
Delta-cell-specific expression of hedgehog pathway Ptch1 receptor in murine and human endocrine pancreas 109
SMO-M2 mutation does not support cell-autonomous Hedgehog activity in cerebellar granule cell precursors 107
KCTD15 inhibits the Hedgehog pathway in Medulloblastoma cells by increasing protein levels of the oncosuppressor KCASH2 107
Numb Isoforms Deregulation in Medulloblastoma and Role of p66 Isoform in Cancer and Neural Stem Cells 105
Downregulation of miR-326 and its host gene β-arrestin1 induces pro survival activity of E2F1 and promotes medulloblastoma growth 103
EZH2, JMJD3 and UTX epigenetically regulate hepatic plasticity inducing retro-differentiation and proliferation of liver cells 102
c-FLIP efficiently rescues TRAF-2(-/-) cells from TNF-induced apoptosis 101
Histone deacetylase and Cullin3-REN KCTD11 ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation 101
Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation 100
Hedgehog-GLI and notch pathways sustain chemoresistance and invasiveness in colorectal cancer and their Inhibition restores chemotherapy efficacy 97
Chromosome 17p Deletion in Human Medulloblastoma: A Missing Checkpoint in the Hedgehog Pathway 95
Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors 95
SALL4 is a CRL3^REN/KCTD11 substrate that drives Sonic Hedgehog-dependent medulloblastoma 94
Identification and Characterization of KCASH2 and KCASH3, 2 Novel Cullin3 Adaptors Suppressing Histone Deacetylase and Hedgehog Activity in Medulloblastoma 92
Inhibition of ErbB receptors, Hedgehog and NF-kappaB signaling by polyphenols in cancer 88
Druggable glycolytic requirement for Hedgehog-dependent neuronal and medulloblastoma growth 87
NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration 87
microRNA-17-92 cluster is a direct Nanog target and controls neural stem cell through Trp53inp1 85
Islet regeneration and pancreatic duct glands in human and experimental diabetes 85
Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells 84
Hedgehog-GLI signalling promotes chemoresistance through the regulation of ABC transporters in colorectal cancer cells 83
Functional cooperation between ASK1 and p21Waf1/Cip1 in the balance of cell-cycle arrest, cell death and tumorigenesis of stressed keratinocytes 83
Specific Protein 1 and p53 Interplay Modulates the Expression of the KCTD-Containing Cullin3 Adaptor Suppressor of Hedgehog 2 83
Alternative splicing of the ErbB-4 cytoplasmic domain and its regulation by hedgehog signaling identify distinct medulloblastoma subsets 82
PCAF ubiquitin ligase activity inhibits Hedgehog/Gli1 signaling in p53-dependent response to genotoxic stress 82
An integrated approach identifies Nhlh1 and Insm1 as Sonic Hedgehog-regulated genes in developing cerebellum and medulloblastoma 81
Cell signalling (communication arising) - Cell survival and a Gadd45-factor deficiency - Reply 79
Hedgehog controls neural stem cells through p53-independent regulation of Nanog 79
Multiple ubiquitin-dependent processing pathways regulate hedgehog/gli signaling: implications for cell development and tumorigenesis. 79
A gene dosage‐dependent effect unveils NBS1 as both a haploinsufficient tumour suppressor and an essential gene for SHH‐medulloblastoma 78
Numb is a suppressor of Hedgehog signaling and targets Gli1 for Itch-dependent ubiquitination. 78
The centrosomal deubiquitylase USP21 regulates Gli1 transcriptional activity and stability 78
MicroRNA profiling in human medulloblastoma 77
Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch- dependent ubiquitination 77
Alternative splicing of ErbB-4 cdytoplasmic domain and regulation by hedgehog signaling identità distinct medulloblastoma subsets. 76
Hedgehog/Gli Control by Ubiquitination/Acetylation Interplay 75
REN KCTD11 is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma. 73
Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal 69
Immunological events during the early phase of infection with Schistosoma mansoni in mice 67
Gli2 Acetylation at Lysine 757 Regulates Hedgehog-Dependent Transcriptional Output by Preventing Its Promoter Occupancy 67
Pharmacological activation of mGlu4 metabotropic glutamate receptors inhibits the growth of medulloblastomas 67
Molecular organization of the cullin E3 ligase adaptor KCTD11 66
Hedgehog signaling pathway in neural development and disease 66
MicroRNAs as biomarkers for CNS cancer and other disorders 62
The emerging role of the KCTD proteins in cancer 62
Gadd45 beta mediates the protective effects of CD40 costimulation against Fas-induced apoptosis 62
Glucocorticoids and neonatal brain injury: The hedgehog connection 61
Methods for modulating the pathway of NF-κB using short hairpin RNA (ShRNA) 60
Hedgehog signalling in colon cancer and stem cells. 58
From single gene analysis to single cell profiling: a new era for precision medicine 58
Hedgehog checkpoints in medulloblastoma: the chromosome 17p-deletion paradigm. 57
Corrigendum: Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma 57
Hedgehog signaling pathway and its targets for treatment in basal cell carcinoma 56
Che-1/AATF binds to RNA polymerase I machinery and sustains ribosomal RNA gene transcription 53
KCTD1 is a new modulator of the KCASH family of Hedgehog suppressors 52
STUDY OF THE TRANSCRIPTIONAL REGULATION OF THE ONCOSUPPRESSOR KCASH2 49
Ferritin heavy chain upregulation by NF-kappaB inhibits TNFalpha-induced apoptosis by suppressing reactive oxygen species. 48
Identification of nuclei from apoptotic, necrotic, and viable lymphoid cells by using multiparameter flow cytometry 48
Suppressors of Hedgehog signalling: linking aberrant development of neural progenitors to tumorigenesis. 47
Gadd45beta mediates the nf-kappab suppression of jnk signalling by targeting mkk7/jnkk2 45
Regulation of the gadd45β promoter by NF-kB 44
Microbiological profiles of dental implants in metabolic syndrome patients: a case-control study 44
MYC upstream region orchestrates resistance to PI3K inhibitors in cancer cells through FOXO3a-mediated autophagic adaptation 43
SCF and IL-33 regulate mouse mast cell phenotypic and functional plasticity supporting a pro-inflammatory microenvironment 42
Protection by herpes simplex virus glycoprotein D against Fas-mediated apoptosis: role of nuclear factor kappaB. 36
Induction of gadd45β by NF-kB down-regulates pro-apoptotic JNK signaling 36
Vismodegib, a small-molecule inhibitor of the Hedgehog pathway for the treatment of advanced cancers 34
The stem cell-associated transcription co-factor, ZNF521, interacts with GLI1 and GLI2 and enhances the activity of the Sonic hedgehog pathway 34
Insights into the structural basis of the GADD45 beta-mediated inactivation of the JNK kinase, MKK7/JNKK2 33
Hypoxia dictates metabolic rewiring of tumors: implications for chemoresistance 33
Hypoxia, endoplasmic reticulum stress and chemoresistance: dangerous liaisons 33
Identificazione di cellule infettate da virus influenzale mediante citometria a flusso 30
Targeting Gli acetylation in Shh-medulloblastoma: A successful preclinical approach 29
The inhibition of IRE1alpha/XBP1 axis prevents EBV-driven lymphomagenesis in NSG mice 22
 Combined treatment with inhibitors of ErbB Receptors and Hh signaling pathways is more effective than single treatment in reducing the growth of malignant mesothelioma both in vitro and in vivo 21
β-arrestin1-E2F1-ac axis regulates physiological apoptosis and cell cycle exit in cellular models of early postnatal cerebellum 19
SCF and IL-33 regulate intestinal mouse mast cell plasticity in colon cancer 17
SMURF1 and SMURF2 directly target GLI1 for ubiquitination and proteasome-dependent degradation 1
Totale 7.292
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Categoria #
all - tutte 21.498
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 21.498
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.067 0 0 0 0 0 221 229 172 159 129 82 75
2020/2021827 54 68 29 52 30 69 58 45 91 214 85 32
2021/20221.102 24 76 104 139 111 30 22 112 106 52 181 145
2022/20231.286 203 316 76 143 114 113 31 83 115 19 52 21
2023/2024904 42 67 58 50 95 183 66 98 15 85 74 71
2024/2025667 61 32 101 160 179 134 0 0 0 0 0 0
Totale 7.292