KCTD containing Cullin3 adaptor, suppressor of Hedgehog (KCASH2) belongs to the KCASH family of proteins, which are involved in the negative regulation of the Sonic Hedgehog (Hh) signaling pathway. All members of KCASH family have shown to be downregulated in Hh dependent Medulloblastoma (Mb), by either allelic loss or promoter methylation. Particularly, KCASH2 expression is reduced also in other tumors, not directly connected with Hh pathway modulation; moreover, chromosome 11q, where KCASH2 is localized, is lost in several sporadic tumors. In turn, correlation studies and data of laboratory show a role of KCASH2 in differentiation and cell cycle regulation, suggesting its fine regulation during development.
STUDY OF THE TRANSCRIPTIONAL REGULATION OF THE ONCOSUPPRESSOR KCASH2 / Angrisani, A.; DI TRANI, CLAUDIA AUGUSTA; Moretti, M.; Izzo, M.; Ciocia, Annagiulia; Fonte, Simone; DE SMAELE, E.. - In: JOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS. - ISSN 0393-974X. - 32:4(2018), pp. 145-145.
STUDY OF THE TRANSCRIPTIONAL REGULATION OF THE ONCOSUPPRESSOR KCASH2
A. ANGRISANIPrimo
;DI TRANI, CLAUDIA AUGUSTA;M. MORETTI;M. IZZO;CIOCIA, ANNAGIULIA;FONTE, SIMONE;E. DE SMAELE
2018
Abstract
KCTD containing Cullin3 adaptor, suppressor of Hedgehog (KCASH2) belongs to the KCASH family of proteins, which are involved in the negative regulation of the Sonic Hedgehog (Hh) signaling pathway. All members of KCASH family have shown to be downregulated in Hh dependent Medulloblastoma (Mb), by either allelic loss or promoter methylation. Particularly, KCASH2 expression is reduced also in other tumors, not directly connected with Hh pathway modulation; moreover, chromosome 11q, where KCASH2 is localized, is lost in several sporadic tumors. In turn, correlation studies and data of laboratory show a role of KCASH2 in differentiation and cell cycle regulation, suggesting its fine regulation during development.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
