Introduction. According to the 2016 World Health Organization classification of Tumors of the Central Nervous System, the term Primitive Neuroectodermal Tumor has been replaced by the term Embryonal Tumor (ET). We present a case of disseminated cerebrospinal ET presenting in an adult patient. Illustrative Case. A 49-year-old male presenting with low back pain, dysuria, and hypoesthesia of the lower extremities referred to our emergency department. Brain and whole spine contrast-enhanced MRI documented a diffusively disseminated heterogeneous neoplasm with intradural extra- and intramedullary involvement of the cervicothoracic tract and cauda equina. A primary biopsy of the lumbosacral localization was performed through L5 bilateral laminectomy. Histologic diagnosis was Embryonal Tumor Not Otherwise Specified. The patient underwent chemotherapy with postoperative adjuvant alternating Vincristine-Doxorubicin-Ifosfamide (VAI) and Ifosfamide-Etoposide (IE). Discussion. Spinal ETs are exceedingly rare especially when presenting in the adult patient. Neurosurgical and oncologic management is still unclear. When feasible, surgical removal should always be performed to obtain a histologic diagnosis. Postoperative adjuvant therapy might entail both chemo- and radiotherapy; however a consensus on this matter is still lacking.

Disseminated cerebrospinal embryonal tumor in the adult / Caporlingua, Alessandro; Armocida, Daniele; Caporlingua, Federico; Lapadula, Gennaro; Elefante, GRAZIA MARIA; Antonelli, Manila; Salvati, Maurizio. - In: CASE REPORTS IN PATHOLOGY. - ISSN 2090-679X. - 2016:(2016). [10.1155/2016/6785459]

Disseminated cerebrospinal embryonal tumor in the adult

CAPORLINGUA, ALESSANDRO
Primo
;
ARMOCIDA, DANIELE
Secondo
;
CAPORLINGUA, FEDERICO;LAPADULA, GENNARO;ELEFANTE, GRAZIA MARIA;ANTONELLI, MANILA
Penultimo
;
SALVATI, Maurizio
Ultimo
2016

Abstract

Introduction. According to the 2016 World Health Organization classification of Tumors of the Central Nervous System, the term Primitive Neuroectodermal Tumor has been replaced by the term Embryonal Tumor (ET). We present a case of disseminated cerebrospinal ET presenting in an adult patient. Illustrative Case. A 49-year-old male presenting with low back pain, dysuria, and hypoesthesia of the lower extremities referred to our emergency department. Brain and whole spine contrast-enhanced MRI documented a diffusively disseminated heterogeneous neoplasm with intradural extra- and intramedullary involvement of the cervicothoracic tract and cauda equina. A primary biopsy of the lumbosacral localization was performed through L5 bilateral laminectomy. Histologic diagnosis was Embryonal Tumor Not Otherwise Specified. The patient underwent chemotherapy with postoperative adjuvant alternating Vincristine-Doxorubicin-Ifosfamide (VAI) and Ifosfamide-Etoposide (IE). Discussion. Spinal ETs are exceedingly rare especially when presenting in the adult patient. Neurosurgical and oncologic management is still unclear. When feasible, surgical removal should always be performed to obtain a histologic diagnosis. Postoperative adjuvant therapy might entail both chemo- and radiotherapy; however a consensus on this matter is still lacking.
2016
primitive neuroectodermal tumors; central-nervous-system; medulloblastomas; children
01 Pubblicazione su rivista::01i Case report
Disseminated cerebrospinal embryonal tumor in the adult / Caporlingua, Alessandro; Armocida, Daniele; Caporlingua, Federico; Lapadula, Gennaro; Elefante, GRAZIA MARIA; Antonelli, Manila; Salvati, Maurizio. - In: CASE REPORTS IN PATHOLOGY. - ISSN 2090-679X. - 2016:(2016). [10.1155/2016/6785459]
File allegati a questo prodotto
File Dimensione Formato  
Caporlingua_Cerebrospinal_2016.pdf

accesso aperto

Note: https://www.hindawi.com/journals/cripa/2016/6785459/
Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 4.36 MB
Formato Adobe PDF
4.36 MB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/935746
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus ND
  • ???jsp.display-item.citation.isi??? 4
social impact