Nanodiamonds are a novel class of nanomaterials which have raised much attention for application in biomedical field, as they combine the possibility of being produced on large scale using relatively inexpensive synthetic processes, of being fluorescent as a consequence of the presence of nitrogen vacancies, of having their surfaces functionalized, and of having good biocompatibility. Among other applications, we mainly focus on drug delivery, including cell interaction, targeting, cancer therapy, gene and protein delivery. In addition, nanodiamonds for bone and dental implants and for antibacterial use is discussed. Techniques for detection and imaging of nanodiamonds in biological tissues are also reviewed, including electron microscopy, fluorescence microscopy, Raman mapping, atomic force microscopy, thermal imaging, magnetic resonance imaging, and positron emission tomography, either in vitro, in vivo, or ex vivo. Toxicological aspects related to the use of nanodiamonds are also discussed. Finally, patents, preclinical and clinical trials based on the use of nanodiamonds for biomedical applications are reviewed.

Biomedical applications of nanodiamonds: an overview / Passeri, Daniele; Rinaldi, Federica; Ingallina, Cinzia; Carafa, Maria; Rossi, Marco; M. L., Terranova; Marianecci, Carlotta. - In: JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY. - ISSN 1533-4880. - 15:(2015), pp. 972-988. [10.1166/jnn.2015.9734]

Biomedical applications of nanodiamonds: an overview

PASSERI, Daniele
Primo
;
RINALDI, FEDERICA
Secondo
;
INGALLINA, CINZIA;CARAFA, Maria;ROSSI, Marco;MARIANECCI, CARLOTTA
Ultimo
2015

Abstract

Nanodiamonds are a novel class of nanomaterials which have raised much attention for application in biomedical field, as they combine the possibility of being produced on large scale using relatively inexpensive synthetic processes, of being fluorescent as a consequence of the presence of nitrogen vacancies, of having their surfaces functionalized, and of having good biocompatibility. Among other applications, we mainly focus on drug delivery, including cell interaction, targeting, cancer therapy, gene and protein delivery. In addition, nanodiamonds for bone and dental implants and for antibacterial use is discussed. Techniques for detection and imaging of nanodiamonds in biological tissues are also reviewed, including electron microscopy, fluorescence microscopy, Raman mapping, atomic force microscopy, thermal imaging, magnetic resonance imaging, and positron emission tomography, either in vitro, in vivo, or ex vivo. Toxicological aspects related to the use of nanodiamonds are also discussed. Finally, patents, preclinical and clinical trials based on the use of nanodiamonds for biomedical applications are reviewed.
Nanodiamond; Biomedicine; Drug Delivery; Diagnostic; Imaging; Therapy; Theranostic.
01 Pubblicazione su rivista::01a Articolo in rivista
Biomedical applications of nanodiamonds: an overview / Passeri, Daniele; Rinaldi, Federica; Ingallina, Cinzia; Carafa, Maria; Rossi, Marco; M. L., Terranova; Marianecci, Carlotta. - In: JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY. - ISSN 1533-4880. - 15:(2015), pp. 972-988. [10.1166/jnn.2015.9734]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/741611
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