The aim of this study was to evaluate the caffeic acid (1) and ester derivatives (2-10) against Candida albicans biofilm and to investigate whether these compounds are able to inhibit the biofilm formation or destroy pre-formed biofilm. Caffeic acid ester 7, cinnamic acid ester 8 and 3,4-dihydroxybenzoic acid ester 10 are more active than fluconazole, used as reference drug, both on biofilm in formation with MIC50 values of 32, 32 and 16 μg/mL respectively, and in the early stage of biofilm formation (4 h) with MIC50 values of 64, 32 and 64 μg/mL respectively. These esters result also more active than fluconazole on mature biofilm (24 h), especially 8 and 10 with MIC50 values of 64 μg/mL
Activity of caffeic acid derivatives against Candida albicans biofilm / DE VITA, Daniela; Friggeri, Laura; D'Auria, Felicia Diodata; Pandolfi, Fabiana; Francesco, Piccoli; Panella, Simona; Palamara, ANNA TERESA; Simonetti, Giovanna; Scipione, Luigi; R., Santo; DI SANTO, Roberto; Costi, Roberta; Tortorella, Silvano. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - ELETTRONICO. - 24:6(2014), pp. 1502-1505. [10.1016/j.bmcl.2014.02.005]
Activity of caffeic acid derivatives against Candida albicans biofilm
DE VITA, DANIELA;FRIGGERI, LAURA;D'AURIA, Felicia Diodata;PANDOLFI, FABIANA;PANELLA, SIMONA;PALAMARA, ANNA TERESA;SIMONETTI, Giovanna;SCIPIONE, Luigi;DI SANTO, Roberto;COSTI, Roberta;TORTORELLA, Silvano
2014
Abstract
The aim of this study was to evaluate the caffeic acid (1) and ester derivatives (2-10) against Candida albicans biofilm and to investigate whether these compounds are able to inhibit the biofilm formation or destroy pre-formed biofilm. Caffeic acid ester 7, cinnamic acid ester 8 and 3,4-dihydroxybenzoic acid ester 10 are more active than fluconazole, used as reference drug, both on biofilm in formation with MIC50 values of 32, 32 and 16 μg/mL respectively, and in the early stage of biofilm formation (4 h) with MIC50 values of 64, 32 and 64 μg/mL respectively. These esters result also more active than fluconazole on mature biofilm (24 h), especially 8 and 10 with MIC50 values of 64 μg/mLI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
