The need for new drugs and new targets is particularly compelling in an era that is witnessing an alarming increase of drug resistance in human pathogens. The identification of new targets of known drugs is a promising approach, which has proven successful in several cases. Here, we describe a database that includes information on 5153 putative drug-target pairs for 150 human pathogens derived from available drug-target crystallographic complexes.
Motivation: The need for new drugs and new targets is particularly compelling in an era that is witnessing an alarming increase of drug resistance in human pathogens. The identification of new targets of known drugs is a promising approach, which has proven successful in several cases. Here, we describe a database that includes information on 5153 putative drug-target pairs for 150 human pathogens derived from available drug-target crystallographic complexes. © 2013 The Author 2013. Published by Oxford University Press. All rights reserved.
TiPs: A database of therapeutic targets in pathogens and associated tools / Lepore, Rosalba; Tramontano, Anna; Via, Allegra. - In: BIOINFORMATICS. - ISSN 1367-4803. - STAMPA. - 29:14(2013), pp. 1821-1822. [10.1093/bioinformatics/btt289]
TiPs: A database of therapeutic targets in pathogens and associated tools
LEPORE, ROSALBA;TRAMONTANO, ANNA;VIA, ALLEGRA
2013
Abstract
The need for new drugs and new targets is particularly compelling in an era that is witnessing an alarming increase of drug resistance in human pathogens. The identification of new targets of known drugs is a promising approach, which has proven successful in several cases. Here, we describe a database that includes information on 5153 putative drug-target pairs for 150 human pathogens derived from available drug-target crystallographic complexes.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
