We describe the synthesis, the physicochemical characterization and the biological evaluation of three novel pH-sensitive systems prepared derivatizing polysorbate 20 (Tween (R) 20) with glycine, N-methylglycine and N,N-dimethyl-glycine (TW20-GLY, TW20-MMG and TW20-DMG). These derivatives form pH-sensitive vesicles and translocate small molecules into cells. The reported systems are efficient drug delivery systems for human hepatoblastoma cells. (C) 2010 Elsevier Ltd. All rights reserved.
Novel Tween (R) 20 derivatives enable the formation of efficient pH-sensitive drug delivery vehicles for human hepatoblastoma / A., Masotti; P., Vicennati; A., Alisi; Marianecci, Carlotta; Rinaldi, Federica; Carafa, Maria; Ortaggi, Giancarlo. - In: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - ISSN 0960-894X. - 20:(2010), pp. 3021-3025. [10.1016/j.bmcl.2010.04.010]
Novel Tween (R) 20 derivatives enable the formation of efficient pH-sensitive drug delivery vehicles for human hepatoblastoma
MARIANECCI, CARLOTTA;RINALDI, FEDERICA;CARAFA, Maria;ORTAGGI, Giancarlo
2010
Abstract
We describe the synthesis, the physicochemical characterization and the biological evaluation of three novel pH-sensitive systems prepared derivatizing polysorbate 20 (Tween (R) 20) with glycine, N-methylglycine and N,N-dimethyl-glycine (TW20-GLY, TW20-MMG and TW20-DMG). These derivatives form pH-sensitive vesicles and translocate small molecules into cells. The reported systems are efficient drug delivery systems for human hepatoblastoma cells. (C) 2010 Elsevier Ltd. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
