We report a young patient harboring a RHOBTB2 likely pathogenic variant with recurrent episodes of headache, dysautonomia and hemiplegia consistent with hemiplegic migraine. Such episodes were responsive to flunarizine prophylaxis. Ictal MRI showed contralateral hemispheric hypoperfusion. This report expands RHOBTB2 spectrum to include hemiplegic migraine and provides insight into the pathophysiology of hemiplegic attacks in this condition.
RHOBTB2-related paroxysmal hemiparesis: from alternating hemiplegia to hemiplegic migraine / Innocenti, A.; Garone, G.; Papetti, L.; Rossi Espagnet, C.; Carboni, A.; Parisi, P.; Valeriani, M.; Specchio, N.. - In: PARKINSONISM & RELATED DISORDERS. - ISSN 1873-5126. - 133:(2025). [10.1016/j.parkreldis.2025.107340]
RHOBTB2-related paroxysmal hemiparesis: from alternating hemiplegia to hemiplegic migraine
Garone G.
Conceptualization
;Parisi P.Supervision
;
2025
Abstract
We report a young patient harboring a RHOBTB2 likely pathogenic variant with recurrent episodes of headache, dysautonomia and hemiplegia consistent with hemiplegic migraine. Such episodes were responsive to flunarizine prophylaxis. Ictal MRI showed contralateral hemispheric hypoperfusion. This report expands RHOBTB2 spectrum to include hemiplegic migraine and provides insight into the pathophysiology of hemiplegic attacks in this condition.| File | Dimensione | Formato | |
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