In recent years, there has been a significant focus on improving the effectiveness of radiotherapy (RT) and particle therapy in treating tumors while minimizing damage to healthy tissue. A promising development is offered by the observation of the so-called FLASH effect, where ultra-high dose rates delivered in a short time have shown to protect healthy tissues while maintaining anti-tumor efficacy. However, conventional detectors face challenges in monitoring charged beams at these ultra-high dose rates due to non-linear effects. To address this challenge, the FlashDC (Flash Detector beam Counter) has been developed. It uses air fluorescence to monitor beam fluence and spatial distribution in real-time with high accuracy and minimal impact on treatment delivery. This innovative detector offers a linear response for various charged beams, dose rates, and energies, making it a cost-effective solution. Multiple prototypes have been developed and optimized using Monte Carlo simulations. The analysis of data from recent test beam campaigns with electrons delivered at FLASH intensities has demonstrated a linear correlation between the detector signal and the delivered dose per pulse, confirming that fluorescence can be used for beam monitoring in FLASH-RT studies. This contribution introduces the FlashDC monitor, discusses its expected performance, and presents preliminary test beam results obtained with electron beams in FLASH mode.

Test beam results of a fluorescence-based monitor for ultra-high dose rates / Trigilio, A.; De Gregorio, A.; De Simoni, M.; Franciosini, G.; Garbini, M.; Magi, M.; Marafini, M.; Mirabelli, R.; Muscato, A.; Patera, V.; Schiavi, A.; Toppi, M.; Traini, G.; Sarti, A.. - In: JOURNAL OF INSTRUMENTATION. - ISSN 1748-0221. - 19:2(2024), pp. 1-13. [10.1088/1748-0221/19/02/c02043]

Test beam results of a fluorescence-based monitor for ultra-high dose rates

Trigilio, A.
;
De Gregorio, A.;De Simoni, M.;Franciosini, G.;Magi, M.;Mirabelli, R.;Muscato, A.;Patera, V.;Schiavi, A.;Toppi, M.;Traini, G.;Sarti, A.
2024

Abstract

In recent years, there has been a significant focus on improving the effectiveness of radiotherapy (RT) and particle therapy in treating tumors while minimizing damage to healthy tissue. A promising development is offered by the observation of the so-called FLASH effect, where ultra-high dose rates delivered in a short time have shown to protect healthy tissues while maintaining anti-tumor efficacy. However, conventional detectors face challenges in monitoring charged beams at these ultra-high dose rates due to non-linear effects. To address this challenge, the FlashDC (Flash Detector beam Counter) has been developed. It uses air fluorescence to monitor beam fluence and spatial distribution in real-time with high accuracy and minimal impact on treatment delivery. This innovative detector offers a linear response for various charged beams, dose rates, and energies, making it a cost-effective solution. Multiple prototypes have been developed and optimized using Monte Carlo simulations. The analysis of data from recent test beam campaigns with electrons delivered at FLASH intensities has demonstrated a linear correlation between the detector signal and the delivered dose per pulse, confirming that fluorescence can be used for beam monitoring in FLASH-RT studies. This contribution introduces the FlashDC monitor, discusses its expected performance, and presents preliminary test beam results obtained with electron beams in FLASH mode.
2024
beam-line instrumentation; beam position and profile monitors; beam-intensity monitors; bunch length monitors; instrumentation for particle-beam therapy; X-ray fluorescence (XRF) systems
01 Pubblicazione su rivista::01a Articolo in rivista
Test beam results of a fluorescence-based monitor for ultra-high dose rates / Trigilio, A.; De Gregorio, A.; De Simoni, M.; Franciosini, G.; Garbini, M.; Magi, M.; Marafini, M.; Mirabelli, R.; Muscato, A.; Patera, V.; Schiavi, A.; Toppi, M.; Traini, G.; Sarti, A.. - In: JOURNAL OF INSTRUMENTATION. - ISSN 1748-0221. - 19:2(2024), pp. 1-13. [10.1088/1748-0221/19/02/c02043]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1704469
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