Meningiomas are uncommon in children and usually arise in the context of tumor-predisposing syndromes. Recently, YAP1-fusions have been identified for the first time as potential NF2-independent oncogenic drivers in the development of meningiomas in pediatric patients. We report a case of a YAP1-fusion-positive atypical meningioma in a young child and compare it with the previous ones reported. Extending the clinico-pathological features of YAP1-fused meningiomas, we suggest additional clues for diagnosis and emphasize the urgent need for an integrated multilayered diagnostic approach, combining data from histological and molecular analyses, neuroradiology, and clinical findings.
Interhemispheric pediatric meningioma, YAP1 fusion-positive / Esposito, Silvia; Marucci, Gianluca; Antonelli, Manila; Miele, Evelina; Modena, Piergiorgio; Giagnacovo, Marzia; Massimino, Maura; Biassoni, Veronica; Taddei, Matilde; Schiariti, Marco Paolo; Doniselli, Fabio Martino; Moscatelli, Marco; Chiapparini, Luisa; Pollo, Bianca. - In: DIAGNOSTICS. - ISSN 2075-4418. - 12:10(2022). [10.3390/diagnostics12102367]
Interhemispheric pediatric meningioma, YAP1 fusion-positive
Antonelli, ManilaConceptualization
;Miele, EvelinaFormal Analysis
;Chiapparini, LuisaPenultimo
Methodology
;
2022
Abstract
Meningiomas are uncommon in children and usually arise in the context of tumor-predisposing syndromes. Recently, YAP1-fusions have been identified for the first time as potential NF2-independent oncogenic drivers in the development of meningiomas in pediatric patients. We report a case of a YAP1-fusion-positive atypical meningioma in a young child and compare it with the previous ones reported. Extending the clinico-pathological features of YAP1-fused meningiomas, we suggest additional clues for diagnosis and emphasize the urgent need for an integrated multilayered diagnostic approach, combining data from histological and molecular analyses, neuroradiology, and clinical findings.File | Dimensione | Formato | |
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