Background Psychogenic Non-Epileptic Seizures (PNES) and Functional Motor Disorders (FMDs) commonly represent the main clinical manifestations of Functional Neurological Disorders (FNDs). Despite their high prevalence in pediatric neurological services, literature on this topic is still spare for this population. The present study aimed to deepen the clinical knowledge of a pediatric FNDs sample through a demographic and clinical characterization of the most recurrent clinical patterns during the pediatric age. Moreover, a comparison of neuropsychological and psychopathological profiles of PNES and FMD patients was carried out to identify specific vulnerabilities and therapeutic targets linked with these different clinical manifestations. Materials and methods A total of 43 FNDs patients (age range 7–17 years old) were retrospectively included in our study, enrolled in two subgroups: 20 with FMDs and 23 with PNES diagnosis. They were inpatients and outpatients referred over a period of 5 years and a standardized neurological, neuropsychological (WISC-IV/WAIS-IV), and psychiatric (CDI-2, MASC-2, ADES, DIS-Q, PID-5) evaluation was assessed. Results In PNES patients the most common clinical phenotypes were functional tonic-clonic (52%) and atonic (32%) manifestations while in the FMDs group were gait alterations (60%), functional myoclonus (35%), and tremor (35%). A higher frequency of cognitive impairment was reported in PNES patients with higher anxiety-depressive symptom rates than FMDs patients. Conclusions Notably, specific neurocognitive and psychopathological profiles were described in PNES and FMDs, highlighting higher cognitive and psychiatric vulnerabilities in PNES, suggesting as well different strategy for therapeutic approaches.

Psychogenic non-epileptic seizures and functional motor disorders in developmental age: A comparison of clinical and psychopathological features / Gigliotti, F.; Di Santo, F.; Cesario, S.; Esposito, D.; Manti, F.; Galosi, S.; Ferrara, M.; Leuzzi, V.; Baglioni, V.. - In: EPILEPSY & BEHAVIOR. - ISSN 1525-5050. - 140:(2023). [10.1016/j.yebeh.2023.109117]

Psychogenic non-epileptic seizures and functional motor disorders in developmental age: A comparison of clinical and psychopathological features

Gigliotti, F.
Primo
;
Di Santo, F.
Secondo
;
Cesario, S.;Esposito, D.;Manti, F.;Galosi, S.;Ferrara, M.;Leuzzi, V.;Baglioni, V.
Ultimo
2023

Abstract

Background Psychogenic Non-Epileptic Seizures (PNES) and Functional Motor Disorders (FMDs) commonly represent the main clinical manifestations of Functional Neurological Disorders (FNDs). Despite their high prevalence in pediatric neurological services, literature on this topic is still spare for this population. The present study aimed to deepen the clinical knowledge of a pediatric FNDs sample through a demographic and clinical characterization of the most recurrent clinical patterns during the pediatric age. Moreover, a comparison of neuropsychological and psychopathological profiles of PNES and FMD patients was carried out to identify specific vulnerabilities and therapeutic targets linked with these different clinical manifestations. Materials and methods A total of 43 FNDs patients (age range 7–17 years old) were retrospectively included in our study, enrolled in two subgroups: 20 with FMDs and 23 with PNES diagnosis. They were inpatients and outpatients referred over a period of 5 years and a standardized neurological, neuropsychological (WISC-IV/WAIS-IV), and psychiatric (CDI-2, MASC-2, ADES, DIS-Q, PID-5) evaluation was assessed. Results In PNES patients the most common clinical phenotypes were functional tonic-clonic (52%) and atonic (32%) manifestations while in the FMDs group were gait alterations (60%), functional myoclonus (35%), and tremor (35%). A higher frequency of cognitive impairment was reported in PNES patients with higher anxiety-depressive symptom rates than FMDs patients. Conclusions Notably, specific neurocognitive and psychopathological profiles were described in PNES and FMDs, highlighting higher cognitive and psychiatric vulnerabilities in PNES, suggesting as well different strategy for therapeutic approaches.
2023
functional neurological disorders; children; PNES; neuropsychiatric disorders; FMD
01 Pubblicazione su rivista::01a Articolo in rivista
Psychogenic non-epileptic seizures and functional motor disorders in developmental age: A comparison of clinical and psychopathological features / Gigliotti, F.; Di Santo, F.; Cesario, S.; Esposito, D.; Manti, F.; Galosi, S.; Ferrara, M.; Leuzzi, V.; Baglioni, V.. - In: EPILEPSY & BEHAVIOR. - ISSN 1525-5050. - 140:(2023). [10.1016/j.yebeh.2023.109117]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1671373
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