Objectives: To develop an easy tool to predict cancer specific (CSS) and disease-free survival (DFS) in patients with bladder cancer treated with radical cystectomy. Methods: Data from a consecutive series of 2395 patients with primitive or progression to muscle invasive bladder cancer (MIBC) undergone to radical cystectomy and lymph nodes dissection in 5 centers were evaluated. Using Cox proportional hazards analyses, the Cancer of the bladder risk assessment (CRAB) nomogram was generated. Accuracy of the nomogram was evaluated by Harrell's C test. Internal validation of the model was performed using 200 bootstraps. Results: Median age was 66 (IQR 58/73) years; 612/2395 (26%) patients presented an advanced pathological stage (≥pT3a); 478/2395 (20%) presented positive lymph nodes. Overall, 729/2395 (30%) presented local or distant recurrence with a median DFS of 42 (IQR 14/89) months. Overall, 642/2395 (27%) died of bladder cancer with a median follow up of 48 (IQR 22/92) months. On univariate Cox proportional hazards analyses, age, stage, and lymph nodes density were a significant predictor of 3 and5 years CSS and DFS. Accuracy of the CRAB nomogram was 0.73 and 0.71 respectively. Conclusion: CRAB nomogram can be a practical and easily applicable tool that may help urologists to classify the long-term CSS and DFS of patients treated with radical cystectomy and to predict the oncological outcome.

Development of a Pocket Nomogram to Predict Cancer and Disease Specific Survival After Radical Cystectomy For Bladder Cancer: The CRAB Nomogram / Cicione, Antonio; Simone, Giuseppe; Lombardo, Riccardo; Franco, Antonio; Nacchia, Antonio; Ghezzo, Nicola; Zammitti, Filippo; Guidotti, Alessio; Gallo, Giacomo; Molinaro, Emilio; Leonardo, Costantino; Gallucci, Michele; Daneshmand, Siamak; Miranda, Gus; Desai, Mihir M; Gill, Inderbir; Abol-Enein, Hassan; Tubaro, Andrea; De Nunzio, Cosimo. - In: CLINICAL GENITOURINARY CANCER. - ISSN 1938-0682. - 21:1(2023), pp. 108-114. [10.1016/j.clgc.2022.08.011]

Development of a Pocket Nomogram to Predict Cancer and Disease Specific Survival After Radical Cystectomy For Bladder Cancer: The CRAB Nomogram

Cicione, Antonio;Lombardo, Riccardo;Franco, Antonio;Nacchia, Antonio;Ghezzo, Nicola;Zammitti, Filippo;Guidotti, Alessio;Gallo, Giacomo;Molinaro, Emilio;Leonardo, Costantino;Gallucci, Michele;Tubaro, Andrea;De Nunzio, Cosimo
2023

Abstract

Objectives: To develop an easy tool to predict cancer specific (CSS) and disease-free survival (DFS) in patients with bladder cancer treated with radical cystectomy. Methods: Data from a consecutive series of 2395 patients with primitive or progression to muscle invasive bladder cancer (MIBC) undergone to radical cystectomy and lymph nodes dissection in 5 centers were evaluated. Using Cox proportional hazards analyses, the Cancer of the bladder risk assessment (CRAB) nomogram was generated. Accuracy of the nomogram was evaluated by Harrell's C test. Internal validation of the model was performed using 200 bootstraps. Results: Median age was 66 (IQR 58/73) years; 612/2395 (26%) patients presented an advanced pathological stage (≥pT3a); 478/2395 (20%) presented positive lymph nodes. Overall, 729/2395 (30%) presented local or distant recurrence with a median DFS of 42 (IQR 14/89) months. Overall, 642/2395 (27%) died of bladder cancer with a median follow up of 48 (IQR 22/92) months. On univariate Cox proportional hazards analyses, age, stage, and lymph nodes density were a significant predictor of 3 and5 years CSS and DFS. Accuracy of the CRAB nomogram was 0.73 and 0.71 respectively. Conclusion: CRAB nomogram can be a practical and easily applicable tool that may help urologists to classify the long-term CSS and DFS of patients treated with radical cystectomy and to predict the oncological outcome.
2023
Bladder Cancer; Cystectomy; Nomogram; Survival
01 Pubblicazione su rivista::01a Articolo in rivista
Development of a Pocket Nomogram to Predict Cancer and Disease Specific Survival After Radical Cystectomy For Bladder Cancer: The CRAB Nomogram / Cicione, Antonio; Simone, Giuseppe; Lombardo, Riccardo; Franco, Antonio; Nacchia, Antonio; Ghezzo, Nicola; Zammitti, Filippo; Guidotti, Alessio; Gallo, Giacomo; Molinaro, Emilio; Leonardo, Costantino; Gallucci, Michele; Daneshmand, Siamak; Miranda, Gus; Desai, Mihir M; Gill, Inderbir; Abol-Enein, Hassan; Tubaro, Andrea; De Nunzio, Cosimo. - In: CLINICAL GENITOURINARY CANCER. - ISSN 1938-0682. - 21:1(2023), pp. 108-114. [10.1016/j.clgc.2022.08.011]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1669863
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