Background: Extra virgin olive oil (EVOO) improves post-prandial glycemia, but the underlying mechanism has not been fully elucidated. We tested the hypothesis that EVOO improves post-prandial glycemia by reducing gut permeability-derived low-grade endotoxemia. Methods: Serum levels of lipopolysaccharides (LPS), zonulin, a marker of gut permeability, glucose, insulin and glucagon-like peptide 1 (GLP1) were measured in 20 patients with impaired fasting glucose (IFG) and 20 healthy subjects (HS) matched for sex and age. The same variables were measured in IFG patients (n = 20) and HS (n = 20) before and after a Mediterranean diet with 10 g EVOO added or not (n = 20) or in IFG patients (n = 20) before and after intake of 40 g chocolate with EVOO added or not. Results: Compared to HS, IFG had higher levels of LPS and zonulin. In HS, meal intake was associated with a significant increase of blood glucose, insulin, and GLP1 with no changes of blood LPS and zonulin. Two hours after a meal intake containing EVOO, IFG patients showed a less significant increase of blood glucose, a more marked increase of blood insulin and GLP1 and a significant reduction of LPS and zonulin compared to IFG patients not given EVOO. Correlation analysis showed that LPS directly correlated with blood glucose and zonulin and inversely with blood insulin. Similar findings were detected in IFG patients given a chocolate added or without EVOO. Conclusion: Addition of EVOO to a Mediterranean diet or chocolate improves gut permeability and low-grade endotoxemia.

Extra virgin olive oil reduces gut permeability and metabolic endotoxemia in diabetic patients / Bartimoccia, Simona; Cammisotto, Vittoria; Nocella, Cristina; DEL BEN, Maria; D’Amico, Alessandra; Castellani, Valentina; Baratta, Francesco; Pignatelli, Pasquale; Loffredo, Lorenzo; Violi, Francesco; Carnevale, Roberto. - In: NUTRIENTS. - ISSN 2072-6643. - 14:10(2022), p. 2153. [10.3390/nu14102153]

Extra virgin olive oil reduces gut permeability and metabolic endotoxemia in diabetic patients

Bartimoccia Simona
Primo
;
Cammisotto Vittoria;Nocella Cristina;Del Ben Maria;D’amico Alessandra;Castellani Valentina;Baratta Francesco;Pignatelli Pasquale;Loffredo Lorenzo;Violi Francesco
Penultimo
;
Carnevale Roberto
Ultimo
2022

Abstract

Background: Extra virgin olive oil (EVOO) improves post-prandial glycemia, but the underlying mechanism has not been fully elucidated. We tested the hypothesis that EVOO improves post-prandial glycemia by reducing gut permeability-derived low-grade endotoxemia. Methods: Serum levels of lipopolysaccharides (LPS), zonulin, a marker of gut permeability, glucose, insulin and glucagon-like peptide 1 (GLP1) were measured in 20 patients with impaired fasting glucose (IFG) and 20 healthy subjects (HS) matched for sex and age. The same variables were measured in IFG patients (n = 20) and HS (n = 20) before and after a Mediterranean diet with 10 g EVOO added or not (n = 20) or in IFG patients (n = 20) before and after intake of 40 g chocolate with EVOO added or not. Results: Compared to HS, IFG had higher levels of LPS and zonulin. In HS, meal intake was associated with a significant increase of blood glucose, insulin, and GLP1 with no changes of blood LPS and zonulin. Two hours after a meal intake containing EVOO, IFG patients showed a less significant increase of blood glucose, a more marked increase of blood insulin and GLP1 and a significant reduction of LPS and zonulin compared to IFG patients not given EVOO. Correlation analysis showed that LPS directly correlated with blood glucose and zonulin and inversely with blood insulin. Similar findings were detected in IFG patients given a chocolate added or without EVOO. Conclusion: Addition of EVOO to a Mediterranean diet or chocolate improves gut permeability and low-grade endotoxemia.
2022
extra virgin olive oil (EVOO); glucagon-like peptide1(GLP1); gut permeability; Impaired fasting glucose (IFG); lipopolysaccharides (LPS); oleuropein; zonulin
01 Pubblicazione su rivista::01a Articolo in rivista
Extra virgin olive oil reduces gut permeability and metabolic endotoxemia in diabetic patients / Bartimoccia, Simona; Cammisotto, Vittoria; Nocella, Cristina; DEL BEN, Maria; D’Amico, Alessandra; Castellani, Valentina; Baratta, Francesco; Pignatelli, Pasquale; Loffredo, Lorenzo; Violi, Francesco; Carnevale, Roberto. - In: NUTRIENTS. - ISSN 2072-6643. - 14:10(2022), p. 2153. [10.3390/nu14102153]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1667563
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