Nanoscale echogenic bubbles (NBs), can be used as a theranostic platform for the localized delivery of encapsulated drugs. However, the generation of NBs is challenging, because they have lifetimes as short as milliseconds in solution. The aim of this work has been the optimization of a preparation method for the generation of stable NBs, characterized by measuring: a) acoustic efficiency, b) nano-size, to ensure passive tumour targeting, c) stability during storage and after injection and d) ability to entrap drugs. NBs are monodisperse and ultrastable, their stability achieved by generation of an amphiphilic multilamellar shell able to efficiently retain the PFC gas. The NBs perform as good acoustic enhancers over a wide frequency range and out of resonant conditions, as tested in both in vitro and in vivo experiments, proving to be a potential platform for the production of versatile carriers to be used in ultrasound-assisted diagnostic, therapeutic and theranostic applications.

Ultrastable shelled PFC nanobubbles: a platform for ultrasound-assisted diagnostics, and therapy / Hanieh, PATRIZIA NADIA; Ricci, Caterina; Bettucci, Andrea; Marotta, Roberto; Mary Moran, Carmel; Cantù, Laura; Carafa, Maria; Rinaldi, Federica; Del Favero, Elena; Marianecci, Carlotta. - In: NANOMEDICINE. - ISSN 1549-9634. - 46(2022), p. 102611. [10.1016/j.nano.2022.102611]

Ultrastable shelled PFC nanobubbles: a platform for ultrasound-assisted diagnostics, and therapy

Patrizia Nadia Hanieh
Primo
;
Andrea Bettucci;Maria Carafa;Federica Rinaldi
;
Carlotta Marianecci
Ultimo
2022

Abstract

Nanoscale echogenic bubbles (NBs), can be used as a theranostic platform for the localized delivery of encapsulated drugs. However, the generation of NBs is challenging, because they have lifetimes as short as milliseconds in solution. The aim of this work has been the optimization of a preparation method for the generation of stable NBs, characterized by measuring: a) acoustic efficiency, b) nano-size, to ensure passive tumour targeting, c) stability during storage and after injection and d) ability to entrap drugs. NBs are monodisperse and ultrastable, their stability achieved by generation of an amphiphilic multilamellar shell able to efficiently retain the PFC gas. The NBs perform as good acoustic enhancers over a wide frequency range and out of resonant conditions, as tested in both in vitro and in vivo experiments, proving to be a potential platform for the production of versatile carriers to be used in ultrasound-assisted diagnostic, therapeutic and theranostic applications.
2022
Nanobubbles; Ultrasound contrast agents; Acoustics; Theranostics; Drug delivery
01 Pubblicazione su rivista::01a Articolo in rivista
Ultrastable shelled PFC nanobubbles: a platform for ultrasound-assisted diagnostics, and therapy / Hanieh, PATRIZIA NADIA; Ricci, Caterina; Bettucci, Andrea; Marotta, Roberto; Mary Moran, Carmel; Cantù, Laura; Carafa, Maria; Rinaldi, Federica; Del Favero, Elena; Marianecci, Carlotta. - In: NANOMEDICINE. - ISSN 1549-9634. - 46(2022), p. 102611. [10.1016/j.nano.2022.102611]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1657542
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