Gut microorganisms and the products of their metabolism thoroughly affect host brain development, function and behavior. Since alterations of brain plasticity and cognition have been demonstrated upon motor, sensorial and social enrichment of the housing conditions, we hypothesized that gut microbiota and metabolome could be altered by environmental stimuli, providing part of the missing link among environmental signals and brain effects. In this preliminary study, metagenomic and metabolomic analyses of mice housed in different environmental conditions, standard and enriched, identify environment-specific microbial communities and metabolic profiles. We show that mice housed in an enriched environment have distinctive microbiota composition with a reduction in gut bacterial richness and biodiversity and are characterized by a metabolomic fingerprint with the increase of formate and acetate and the decrease of bile salts. We demonstrate that mice treated with a mixture of formate and acetate recapitulate some of the brain plasticity effects modulated by environmental enrichment, such as hippocampal neurogenesis, neurotrophin production, shortterm plasticity and cognitive behaviors, that can be further exploited to decipher the mechanisms involved in experience-dependent brain plasticity.

Short-chain fatty acids promote the effect of environmental signals on the gut microbiome and metabolome in mice / Marrocco, Francesco; Delli Carpini, Mary; Garofalo, Stefano; Giampaoli, Ottavia; De Felice, Eleonora; Di Castro, Maria Amalia; Maggi, Laura; Scavizzi, Ferdinando; Raspa, Marcello; Marini, Federico; Tomassini, Alberta; Nicolosi, Roberta; Cason, Carolina; Trettel, Flavia; Miccheli, Alfredo; Iebba, Valerio; D’Alessandro, Giuseppina; Limatola, Cristina. - In: COMMUNICATIONS BIOLOGY. - ISSN 2399-3642. - 5:1(2022), pp. 1-13. [10.1038/s42003-022-03468-9]

Short-chain fatty acids promote the effect of environmental signals on the gut microbiome and metabolome in mice

Marrocco, Francesco;Delli Carpini, Mary;Garofalo, Stefano
Investigation
;
Giampaoli, Ottavia;De Felice, Eleonora;Di Castro, Maria Amalia;Maggi, Laura;Raspa, Marcello;Marini, Federico
Investigation
;
Tomassini, Alberta;Nicolosi, Roberta;Trettel, Flavia;Miccheli, Alfredo;Iebba, Valerio;D’Alessandro, Giuseppina
Penultimo
Conceptualization
;
Limatola, Cristina
2022

Abstract

Gut microorganisms and the products of their metabolism thoroughly affect host brain development, function and behavior. Since alterations of brain plasticity and cognition have been demonstrated upon motor, sensorial and social enrichment of the housing conditions, we hypothesized that gut microbiota and metabolome could be altered by environmental stimuli, providing part of the missing link among environmental signals and brain effects. In this preliminary study, metagenomic and metabolomic analyses of mice housed in different environmental conditions, standard and enriched, identify environment-specific microbial communities and metabolic profiles. We show that mice housed in an enriched environment have distinctive microbiota composition with a reduction in gut bacterial richness and biodiversity and are characterized by a metabolomic fingerprint with the increase of formate and acetate and the decrease of bile salts. We demonstrate that mice treated with a mixture of formate and acetate recapitulate some of the brain plasticity effects modulated by environmental enrichment, such as hippocampal neurogenesis, neurotrophin production, shortterm plasticity and cognitive behaviors, that can be further exploited to decipher the mechanisms involved in experience-dependent brain plasticity.
2022
enriched environment; SCFA; gut microbiota; metabolome
01 Pubblicazione su rivista::01a Articolo in rivista
Short-chain fatty acids promote the effect of environmental signals on the gut microbiome and metabolome in mice / Marrocco, Francesco; Delli Carpini, Mary; Garofalo, Stefano; Giampaoli, Ottavia; De Felice, Eleonora; Di Castro, Maria Amalia; Maggi, Laura; Scavizzi, Ferdinando; Raspa, Marcello; Marini, Federico; Tomassini, Alberta; Nicolosi, Roberta; Cason, Carolina; Trettel, Flavia; Miccheli, Alfredo; Iebba, Valerio; D’Alessandro, Giuseppina; Limatola, Cristina. - In: COMMUNICATIONS BIOLOGY. - ISSN 2399-3642. - 5:1(2022), pp. 1-13. [10.1038/s42003-022-03468-9]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1638245
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